Serum Biomarkers of Disease Activity in Longitudinal Assessment of Patients with ANCA‐Associated Vasculitis

Autor: Paul A. Monach, Roscoe L. Warner, Robert Lew, Gunnar Tómasson, Ulrich Specks, John H. Stone, Fernando C. Fervenza, Gary S. Hoffman, Cees G. M. Kallenberg, Carol A. Langford, Philip Seo, E. William St. Clair, Robert Spiera, Kent J. Johnson, Peter A. Merkel

Publikováno v: ACR Open Rheumatology, Vol 4, Iss 2, Pp 168-176 (2022)

Objective Improved biomarkers of current disease activity and prediction of relapse are needed in antineutrophil cytoplasmic antibody–associated vasculitis (AAV). For clinical relevance, biomarkers must perform well longitudinally in patients on tr

Externí odkaz: https://doaj.org/article/1b4d66b46e4b402cb73650c340d67054

Activation of a Latent Epitope Causing Differential Binding of Antineutrophil Cytoplasmic Antibodies to Proteinase 3

Autor: Marta Casal, Moura, Gwen E, Thompson, Darlene R, Nelson, Lynn A, Fussner, Amber M, Hummel, Dieter E, Jenne, Daniel, Emerling, Fernando C, Fervenza, Cees G M, Kallenberg, Carol A, Langford, W Joseph, McCune, Peter A, Merkel, Paul A, Monach, Philip, Seo, Robert F, Spiera, E William, St Clair, Steven R, Ytterberg, John H, Stone, William H, Robinson, Ulrich, Specks

Publikováno v: Arthritis & Rheumatology. 75:748-759

Proteinase 3 (PR3) is the major antigen for anti-neutrophil cytoplasmic antibodies (ANCAs) in the systemic autoimmune vasculitis, granulomatosis with polyangiitis (GPA). PR3 anti-neutrophil cytoplasmic antibodies (PR3-ANCAs) recognize different epito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::217c0e0a91fc7f243c0e23863cd966ce
https://doi.org/10.1002/art.42418

Transancestral mapping and genetic load in systemic lupus erythematosus

Autor: Carl D. Langefeld, Hannah C. Ainsworth, Deborah S. Cunninghame Graham, Jennifer A. Kelly, Mary E. Comeau, Miranda C. Marion, Timothy D. Howard, Paula S. Ramos, Jennifer A. Croker, David L. Morris, Johanna K. Sandling, Jonas Carlsson Almlöf, Eduardo M. Acevedo-Vásquez, Graciela S. Alarcón, Alejandra M. Babini, Vicente Baca, Anders A. Bengtsson, Guillermo A. Berbotto, Marc Bijl, Elizabeth E. Brown, Hermine I. Brunner, Mario H. Cardiel, Luis Catoggio, Ricard Cervera, Jorge M. Cucho-Venegas, Solbritt Rantapää Dahlqvist, Sandra D’Alfonso, Berta Martins Da Silva, Iñigo de la Rúa Figueroa, Andrea Doria, Jeffrey C. Edberg, Emőke Endreffy, Jorge A. Esquivel-Valerio, Paul R. Fortin, Barry I. Freedman, Johan Frostegård, Mercedes A. García, Ignacio García de la Torre, Gary S. Gilkeson, Dafna D. Gladman, Iva Gunnarsson, Joel M. Guthridge, Jennifer L. Huggins, Judith A. James, Cees G. M. Kallenberg, Diane L. Kamen, David R. Karp, Kenneth M. Kaufman, Leah C. Kottyan, László Kovács, Helle Laustrup, Bernard R. Lauwerys, Quan-Zhen Li, Marco A. Maradiaga-Ceceña, Javier Martín, Joseph M. McCune, David R. McWilliams, Joan T. Merrill, Pedro Miranda, José F. Moctezuma, Swapan K. Nath, Timothy B. Niewold, Lorena Orozco, Norberto Ortego-Centeno, Michelle Petri, Christian A. Pineau, Bernardo A. Pons-Estel, Janet Pope, Prithvi Raj, Rosalind Ramsey-Goldman, John D. Reveille, Laurie P. Russell, José M. Sabio, Carlos A. Aguilar-Salinas, Hugo R. Scherbarth, Raffaella Scorza, Michael F. Seldin, Christopher Sjöwall, Elisabet Svenungsson, Susan D. Thompson, Sergio M. A. Toloza, Lennart Truedsson, Teresa Tusié-Luna, Carlos Vasconcelos, Luis M. Vilá, Daniel J. Wallace, Michael H. Weisman, Joan E. Wither, Tushar Bhangale, Jorge R. Oksenberg, John D. Rioux, Peter K. Gregersen, Ann-Christine Syvänen, Lars Rönnblom, Lindsey A. Criswell, Chaim O. Jacob, Kathy L. Sivils, Betty P. Tsao, Laura E. Schanberg, Timothy W. Behrens, Earl D. Silverman, Marta E. Alarcón-Riquelme, Robert P. Kimberly, John B. Harley, Edward K. Wakeland, Robert R. Graham, Patrick M. Gaffney, Timothy J. Vyse

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)

Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong ethnic and gender bias. In a transancestral genetic association study, Langefeldet al. identify 24 novel regions associated with risk to lupus and propose a cumulative hits hyp

Externí odkaz: https://doaj.org/article/a68227bc3ba0457486591e4743061bf9

Autoreactive plasmablasts after B cell depletion with rituximab and relapses in ANCA-associated vasculitis

Autor: Alvise, Berti, Sophie, Hillion, Maximilian F, Konig, Marta, Casal Moura, Amber M, Hummel, Eva, Carmona, Tobias, Peikert, Fernando C, Fervenza, Cees G M, Kallenberg, Carol A, Langford, Peter A, Merkel, Paul A, Monach, Philip, Seo, Robert F, Spiera, Paul, Brunetta, E William, St Clair, Kristina M, Harris, John H, Stone, Guido, Grandi, Jacques-Olivier, Pers, Ulrich, Specks, Divi, Cornec

Publikováno v: Arthritisrheumatology (Hoboken, N.J.).

Autoreactive B cells are responsible for ANCA production in ANCA-associated vasculitis (AAV). Rituximab depletes circulating B cells including autoreactive ones. We aimed to evaluate changes and associations with relapse of the circulating autoreacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::813b3edd4452c6b8c59889c8e2796c9d
https://pubmed.ncbi.nlm.nih.gov/36281741

Addition of an online, validated family history questionnaire to the Dutch FIT-based screening programme did not improve its diagnostic yield

Autor: Evelien Bongers, Victorine H. Roos, Patrick M.M. Bossuyt, Frank G. J. Kallenberg, Evelien Dekker, Cora M. Aalfs, Manon van der Vlugt

Publikováno v: British Journal of Cancer
British journal of cancer, 122(12), 1865-1871. Nature Publishing Group

Background Faecal immunochemical testing (FIT) is suboptimal in detecting advanced neoplasia (AN). To increase the sensitivity and yield of a FIT-based screening programme, FIT could be combined with risk factors for AN. We evaluated the incremental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05bf4ce55d5a254dbde4143225a83f5d
https://doi.org/10.1038/s41416-020-0832-8