Zobrazeno 1 - 10
of 690
pro vyhledávání: '"G A, Grant"'
Autor:
Takeshi Kaizuka, Taisei Hirouchi, Takeo Saneyoshi, Toshihiko Shirafuji, Mark O Collins, Seth G N Grant, Yasunori Hayashi, Toru Takumi
Publikováno v:
PLoS Biology, Vol 22, Iss 3, p e3002006 (2024)
Proteome analyses of the postsynaptic density (PSD), a proteinaceous specialization beneath the postsynaptic membrane of excitatory synapses, have identified several thousands of proteins. While proteins with predictable functions have been well stud
Externí odkaz:
https://doaj.org/article/eb1ee277ee014075a0fa347c43877bf9
Autor:
Kristyna Kupkova, Savera J. Shetty, Marilyn G. Pray-Grant, Patrick A. Grant, Rashidul Haque, William A. Petri, David T. Auble
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-20 (2023)
Abstract Background Stunting is a global health problem affecting hundreds of millions of children worldwide and contributing to 45% of deaths in children under the age of five. Current therapeutic interventions have limited efficacy. Understanding t
Externí odkaz:
https://doaj.org/article/d2d3e2d7b9f44296856666ff5702d2fd
Autor:
G. R. Grant, J. H. T. Williams, S. Naeher, O. Seki, E. L. McClymont, M. O. Patterson, A. M. Haywood, E. Behrens, M. Yamamoto, K. Johnson
Publikováno v:
Climate of the Past, Vol 19, Pp 1359-1381 (2023)
Based on Nationally Determined Contributions concurrent with Shared Socioeconomic Pathways (SSPs) 2-4.5, the IPCC predicts global warming of 2.1–3.5 ∘C (very likely range 10–90th percentile) by 2100 CE. However, global average temperature is a
Externí odkaz:
https://doaj.org/article/ae8cbc3ec3584fd498cdbb1d84cba24c
Autor:
Calum Bonthron, Sarah Burley, Matthew J Broadhead, Vanya Metodieva, Seth G N Grant, Siddharthan Chandran, Gareth B Miles
Publikováno v:
PLoS ONE, Vol 19, Iss 8, p e0306423 (2024)
Hyperexcitability of motor neurons and spinal cord motor circuitry has been widely reported in the early stages of Amyotrophic Lateral Sclerosis (ALS). Changes in the relative amount of excitatory to inhibitory inputs onto a neuron (E:I synaptic rati
Externí odkaz:
https://doaj.org/article/5eddee5f793c4dbe8f33a152d267b332
Autor:
Laura Tomas-Roca, Zhen Qiu, Erik Fransén, Ragini Gokhale, Edita Bulovaite, David J. Price, Noboru H. Komiyama, Seth G. N. Grant
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Brain-wide mapping of synapse molecular composition in Pax6 mutant mice shows remodelling and restoration of synaptome architecture during development, a possible means of conferring resilience to genetic disorders.
Externí odkaz:
https://doaj.org/article/b8923dd1e372410a935a5555609e5aef
Autor:
Matthew J. Broadhead, Ani Ayvazian-Hancock, Katherine Doucet, Owen Kantelberg, Lesley Motherwell, Fei Zhu, Seth G. N. Grant, Mathew H. Horrocks, Gareth B. Miles
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Amyotrophic Lateral Sclerosis (ALS) is characterised by a loss of motor neurons in the brain and spinal cord that is preceded by early-stage changes in synapses that may be associated with TAR-DNA-Binding Protein 43 (TDP-43) pathology. Cellular inclu
Externí odkaz:
https://doaj.org/article/e5081c3854aa45ba9122fdc83da492db
Autor:
L. Baumann-Birkbeck, S. Anoopkumar-Dukie, S. A. Khan, M. J. Cheesman, M. O’Donoghue, G. D. Grant
Publikováno v:
BMC Medical Education, Vol 21, Iss 1, Pp 1-10 (2021)
Abstract Background Pharmacy practice education requires the development of proficiencies and an understanding of clinical microbiology. Learning in this area could be delivered using practical laboratory exercises, or potentially, simulation-based e
Externí odkaz:
https://doaj.org/article/45f19ad3e6054b89843e17e6893037e5
Autor:
Oksana Sorokina, Colin Mclean, Mike D. R. Croning, Katharina F. Heil, Emilia Wysocka, Xin He, David Sterratt, Seth G. N. Grant, Thomas I. Simpson, J. Douglas Armstrong
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Genes encoding synaptic proteins are highly associated with neuronal disorders many of which show clinical co-morbidity. We integrated 58 published synaptic proteomic datasets that describe over 8000 proteins and combined them with direct pr
Externí odkaz:
https://doaj.org/article/3100788543c544378e78f9e3f69c92a7
Autor:
Matthew J. Broadhead, Calum Bonthron, Lauren Arcinas, Sumi Bez, Fei Zhu, Frances Goff, Jonathan Nylk, Kishan Dholakia, Frank Gunn-Moore, Seth G. N. Grant, Gareth B. Miles
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-3 (2021)
Externí odkaz:
https://doaj.org/article/63c88a95eb4f46b78445ad9becf78b92
Autor:
Ryuichi Nakajima, Keizo Takao, Satoko Hattori, Hirotaka Shoji, Noboru H. Komiyama, Seth G. N. Grant, Tsuyoshi Miyakawa
Publikováno v:
Neuropsychopharmacology Reports, Vol 39, Iss 3, Pp 223-237 (2019)
Abstract Aims Synaptic Ras GTPase‐activating protein 1 (SYNGAP1) regulates synaptic plasticity through AMPA receptor trafficking. SYNGAP1 mutations have been found in human patients with intellectual disability (ID) and autism spectrum disorder (AS
Externí odkaz:
https://doaj.org/article/a92d454122564c088f1fa7e14ca8ee77