Zobrazeno 1 - 8
of 8
pro vyhledávání: '"G A, Bohme"'
Autor:
Marguerite, Le Marois, Camille, Sanson, Magali-Anne, Maizières, Michel, Partiseti, G Andrees, Bohme
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 396:161-166
Clozapine is an atypical neuroleptic used to manage treatment-resistant schizophrenia which is known to inhibit cardiac hERG/K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4536ccfd145f74b1b9f35d6c4e6cf374
https://doi.org/10.1007/s00210-022-02314-3
https://doi.org/10.1007/s00210-022-02314-3
Autor:
Camille, Sanson, Rachid, Boukaiba, Sylvie, Houtmann, Magali-Anne, Maizières, Sophie, Fouconnier, Michel, Partiseti, G Andrees, Bohme
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 395:735-740
Drinking fresh grapefruit juice is associated with a significant prolongation of the QT segment on the electrocardiogram (ECG) in healthy volunteers. Among the prominent polyphenols contained in citrus fruits and primarily in grapefruit, the flavonoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84a2acbe1f525ae531ae0336c9ed1294
https://doi.org/10.1007/s00210-022-02240-4
https://doi.org/10.1007/s00210-022-02240-4
Publikováno v:
Assay and Drug Development Technologies
Inwardly rectifying IK1 potassium currents of the heart control the resting membrane potential of ventricular cardiomyocytes during diastole and contribute to their repolarization after each action potential. Mutations in the gene encoding Kir2.1 cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436f02d8e40d5ddbccdad38bf7627432
http://europepmc.org/articles/PMC6479253
http://europepmc.org/articles/PMC6479253
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1641
The human Ether-a-go-go Related Gene (hERG) product has been identified as a central ion channel underlying both familial forms of elongated QT interval on the electrocardiogram and drug-induced elongation of the same QT segment. Indeed, reduced func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1dfa2b5b9bdcba1f879048ab2311f37f
https://pubmed.ncbi.nlm.nih.gov/28748465
https://pubmed.ncbi.nlm.nih.gov/28748465
Publikováno v:
Methods in Molecular Biology ISBN: 9781493971701
The human Ether-a-go-go Related Gene (hERG) product has been identified as a central ion channel underlying both familial forms of elongated QT interval on the electrocardiogram and drug-induced elongation of the same QT segment. Indeed, reduced func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45e8f3ed8fde6309183f950aa6abd7ff
https://doi.org/10.1007/978-1-4939-7172-5_10
https://doi.org/10.1007/978-1-4939-7172-5_10
Publikováno v:
Movement disorders : official journal of the Movement Disorder Society. 16(6)
An abnormal increase in the activity of neurons of the subthalamic nucleus is a key pathophysiological feature of Parkinson's disease. We sought to determine whether riluzole, a sodium channel inhibitor that interferes with glutamatergic neurotransmi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6c327ab1d350720f5559abd0fc6a8631
https://pubmed.ncbi.nlm.nih.gov/11748743
https://pubmed.ncbi.nlm.nih.gov/11748743
Autor:
J, Pratt, P, Jimonet, G A, Bohme, A, Boireau, D, Damour, M W, Debono, A, Genevois-Borella, J C, Randle, Y, Ribeill, J M, Stutzmann, M, Vuilhorgne, S, Mignani
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(24)
The over-stimulation of excitatory amino acid receptors such as the glutamate AMPA receptor has been suggested to be associated with neurodegenerative disorders. Here we describe an original series of readily water soluble 4-oxo-imidazo[1,2-a] indeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c01863c7b4abf0881c0f37975861c2de
https://pubmed.ncbi.nlm.nih.gov/11133083
https://pubmed.ncbi.nlm.nih.gov/11133083
Autor:
J M, Stutzmann, G A, Bohme, A, Boireau, D, Damour, M W, Debono, A, Genevois-Borella, A, Imperato, P, Jimonet, J, Pratt, J C, Randle, Y, Ribeill, M, Vuilhorgne, S, Mignani
Publikováno v:
Bioorganicmedicinal chemistry letters. 10(10)
A novel series of 2-substituted-4,5-dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazine derivatives was synthesised. One of them, 4e-a highly water soluble compound exhibited a nanomolar affinity and demonstrated competitive antagonist properties at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::735ca79706c36ea211ad611ebf00595b
https://pubmed.ncbi.nlm.nih.gov/10843235
https://pubmed.ncbi.nlm.nih.gov/10843235