Zobrazeno 1 - 7
of 7
pro vyhledávání: '"G A, Altenberg"'
Publikováno v:
The Biochemical journal. 338
Many membrane proteins that belong to the ATP-binding cassette (ABC) superfamily are clinically important, including the cystic fibrosis transmembrane conductance regulator, the sulphonylurea receptor and P-glycoprotein (multidrug resistance gene pro
Publikováno v:
The Journal of biological chemistry. 269(10)
The P-glycoprotein (Pgp), a plasma membrane protein overexpressed in multidrug-resistant tumor cells, is thought to be both an ATPase that actively exports cytotoxic drugs and a Cl- channel activated by cell swelling. The partial reversal of multidru
Publikováno v:
Cancer research. 54(3)
P-glycoprotein-associated Cl- conductance is activated by cell swelling; the ensuing Cl- efflux is thought to contribute to cell volume regulation. We tested this hypothesis in human breast cancer cells transfected with human mdr1 complementary DNA,
Autor:
G A, Altenberg
Publikováno v:
Mineral and electrolyte metabolism. 16(4)
The intracellular alkalinization produced when extracellular potassium concentration is increased above its normal levels was studied in the rat diaphragm muscle by determination of the steady-state distribution of [14C]-5,5-dimethyl-2,4-oxazolidined
Publikováno v:
Anti-Cancer Drugs. 5:7
Publikováno v:
Acta physiologica et pharmacologica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia. 36(2)
Under the effect of amiloride Na excretion increased and K excretion decreased. These urinary changes were mainly due to alterations in urinary concentration of Na and K with little or no change in urinary volume. Neither plasma Mg concentration nor
Publikováno v:
Acta physiologica et pharmacologica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia. 36(2)
In five subjects with normal renal function, intravenous dopamine, at a rate of 6 ug/kg/min, produces a renal vasodilation, increase in Na excretion and reduction in urinary osmolality, without modification in glomerular filtration rate. These effect