Zobrazeno 1 - 10
of 230
pro vyhledávání: '"Gαq"'
Autor:
Gerald Thiel, Oliver G. Rössler
Publikováno v:
Molecules, Vol 29, Iss 11, p 2602 (2024)
Transient receptor potential melastatin-8 (TRPM8) is a cation channel that is activated by cold and “cooling agents” such as menthol and icilin, which induce a cold sensation. The stimulation of TRPM8 activates an intracellular signaling cascade
Externí odkaz:
https://doaj.org/article/da60c03bb16348ca8b24b74fa0a9d21c
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Rodolfo Daniel Cervantes-Villagrana, Víctor Manuel Color-Aparicio, Alejandro Castillo-Kauil, Irving García-Jiménez, Yarely Mabell Beltrán-Navarro, Guadalupe Reyes-Cruz, José Vázquez-Prado
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 21, p 15734 (2023)
Oncogenic Gαq causes uveal melanoma via non-canonical signaling pathways. This constitutively active mutant GTPase is also found in cutaneous melanoma, lung adenocarcinoma, and seminoma, as well as in benign vascular tumors, such as congenital heman
Externí odkaz:
https://doaj.org/article/8967b6ec8f7a4f7e934ad52d5fa61678
Autor:
Sushmita Chakraborty, Bianca Handrick, Dayoung Yu, Konrad A. Bode, Anna Hafner, Judith Schenz, Dominik Schaack, Florian Uhle, Taro Tachibana, Shigeki Kamitani, Thomas Vogl, Katharina F. Kubatzky
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2023)
IntroductionThe bacterial protein toxin Pasteurella multocida toxin (PMT) mediates RANKL-independent osteoclast differentiation. Although these osteoclasts are smaller, their resorptive activity is high which helps in efficient destruction of nasal t
Externí odkaz:
https://doaj.org/article/88107bbf108748e8a4856b885d17e219
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
The G proteins have emerged as essential molecular switches in a wide variety of signal transduction pathways. Gαq, encoded by G protein subunit alpha q (gnaq), is a member of the G proteins and participates in regulating important biological activi
Externí odkaz:
https://doaj.org/article/b617e17423f440cbb98558a1f82dfb7c
Publikováno v:
Frontiers in Human Neuroscience, Vol 16 (2022)
Port-wine birthmarks (PWBs) are caused by somatic, mosaic mutations in the G protein guanine nucleotide binding protein alpha subunit q (GNAQ) and are characterized by the formation of dilated, dysfunctional blood vessels in the dermis, eyes, and/or
Externí odkaz:
https://doaj.org/article/c6e8b80429be423e9b6302e8a0afbfe3
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Dongxue Wang, Yunjin Yao, Shiqi Wang, Yifei Hou, Lanxue Zhao, Hao Wang, Hongzhuan Chen, Jianrong Xu
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7356 (2023)
The selectivity of drugs for G protein-coupled receptor (GPCR) signaling pathways is crucial for their therapeutic efficacy. Different agonists can cause receptors to recruit effector proteins at varying levels, thus inducing different signaling resp
Externí odkaz:
https://doaj.org/article/a9098eb6623a49a591ecb6acd0198d0e
Autor:
Wen-Ling Dai, Yi-Ni Bao, Ji-Fa Fan, Bin Ma, Shan-Shan Li, Wan-Li Zhao, Bo-Yang Yu, Ji-Hua Liu
Publikováno v:
Journal of Advanced Research, Vol 28, Iss , Pp 139-148 (2021)
Introduction: Spinal N-methyl-D-aspartate receptor (NMDAR) is vital in chronic pain, while NMDAR antagonists have severe side effects. NMDAR has been reported to be controlled by G protein coupled receptors (GPCRs), which might present new therapeuti
Externí odkaz:
https://doaj.org/article/c0ac096b476046a196d81f11b30cec65
Publikováno v:
AIMS Neuroscience, Vol 7, Iss 4, Pp 438-458 (2020)
Major depressive disorder (MDD) is highly comorbid with anxiety disorders. It has been reported that the bed nucleus of the stria terminalis (BNST) is important for the induction of anxiety and MDD. Recently, the Gαq protein signaling within the BNS
Externí odkaz:
https://doaj.org/article/707ea2556eed4839854750431dbde965