Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Gürol M Süel"'
Autor:
Xiaoling Zhai, Joseph W Larkin, Kaito Kikuchi, Samuel E Redford, Ushasi Roy, Gürol M Süel, Andrew Mugler
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 12, p e1007508 (2019)
Signal propagation over long distances is a ubiquitous feature of multicellular communities, but cell-to-cell variability can cause propagation to be highly heterogeneous. Simple models of signal propagation in heterogenous media, such as percolation
Externí odkaz:
https://doaj.org/article/9cf19658a31346ce89934300a71ebfc8
Publikováno v:
Molecular Systems Biology, Vol 12, Iss 5, Pp 1-13 (2016)
Abstract How can changes in growth rate affect the regulatory networks behavior and the outcomes of cellular differentiation? We address this question by focusing on starvation response in sporulating Bacillus subtilis. We show that the activity of s
Externí odkaz:
https://doaj.org/article/c3711842368849edb4ccb778f8583045
Autor:
Andrew Mugler, Mark Kittisopikul, Luke Hayden, Jintao Liu, Chris H Wiggins, Gürol M Süel, Aleksandra M Walczak
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 3, p e1004793 (2016)
Gene regulatory circuits must contend with intrinsic noise that arises due to finite numbers of proteins. While some circuits act to reduce this noise, others appear to exploit it. A striking example is the competence circuit in Bacillus subtilis, wh
Externí odkaz:
https://doaj.org/article/3021e4a057e540d3adcf9b7ca032a8db
Autor:
Anna Kuchina, Lorena Espinar, Tolga Çağatay, Alejandro O Balbin, Fang Zhang, Alma Alvarado, Jordi Garcia‐Ojalvo, Gürol M Süel
Publikováno v:
Molecular Systems Biology, Vol 7, Iss 1, Pp 1-11 (2011)
Abstract Multipotent differentiation, where cells adopt one of several possible fates, occurs in diverse systems ranging from bacteria to mammals. This decision‐making process is driven by multiple differentiation programs that operate simultaneous
Externí odkaz:
https://doaj.org/article/37947b28a911456db7f4ad02a6f206f1
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132948 (2015)
Bacteria predominantly reside in microbial communities known as biofilms, where cells are encapsulated and protected by the extracellular matrix (ECM). While all biofilm cells benefit from the ECM, only a subgroup of cells carries the burden of produ
Externí odkaz:
https://doaj.org/article/e957caf6354248d1aa259fce1f7af213
Publikováno v:
PLoS Computational Biology, Vol 7, Iss 11, p e1002273 (2011)
Cells must make reliable decisions under fluctuating extracellular conditions, but also be flexible enough to adapt to such changes. How cells reconcile these seemingly contradictory requirements through the dynamics of cellular decision-making is po
Externí odkaz:
https://doaj.org/article/2b93f33f0e2541fd8409f0b067182562
Autor:
Daniel Segrè, Sara Mitri, Wenying Shou, Gürol M. Süel, Itzhak Mizrahi, Libusha Kelly, María Rebolleda-Gómez, Christoph Ratzke, C. Brandon Ogbunugafor, Julia A. Schwartzman, Sergey Kryazhimskiy, Gabriel E. Leventhal, Christian Kost, Thomas Bell
Publikováno v:
Cell Systems. 14:91-97
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f72b2d7651644530e918d76fdcbe2cb
https://doi.org/10.1016/j.cels.2023.01.001
https://doi.org/10.1016/j.cels.2023.01.001
Autor:
Kaito Kikuchi, Leticia Galera-Laporta, Colleen Weatherwax, Jamie Y. Lam, Eun Chae Moon, Emmanuel A. Theodorakis, Jordi Garcia-Ojalvo, Gürol M. Süel
Publikováno v:
Science. 378:43-49
The dormant state of bacterial spores is generally thought to be devoid of biological activity. We show that despite continued dormancy, spores can integrate environmental signals over time through a preexisting electrochemical potential. Specificall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95bd1bbdcc5cce34f5583fe381fcdfd9
https://doi.org/10.1126/science.abl7484
https://doi.org/10.1126/science.abl7484
Bacterial colonies benefit from cellular heterogeneity, with cells differentiating into diverse states of physiology and gene expression. As colonies grow, such cells in distinct states arrange into spatial patterns. To uncover the functional role of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2709c9cb7c48aa486a9c03f2ef148df
https://doi.org/10.1101/2022.05.10.491419
https://doi.org/10.1101/2022.05.10.491419
Publikováno v:
Biophys J
Many multicellular communities propagate signals in a directed manner via excitable waves. Cell-to-cell heterogeneity is a ubiquitous feature of multicellular communities, but the effects of heterogeneity on wave propagation are still unclear. Here w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b587dd8182d985fb7dce73c069731b9
https://doi.org/10.1016/j.bpj.2020.02.007
https://doi.org/10.1016/j.bpj.2020.02.007