Zobrazeno 1 - 10
of 1 034
pro vyhledávání: '"Güntert, P"'
Autor:
Dhiman Ghosh, Felix Torres, Matthias M. Schneider, Dzmitry Ashkinadze, Harindranath Kadavath, Yanick Fleischmann, Simon Mergenthal, Peter Güntert, Georg Krainer, Ewa A. Andrzejewska, Lily Lin, Jiapeng Wei, Enrico Klotzsch, Tuomas Knowles, Roland Riek
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The complex kinetics of disease-related amyloid aggregation of proteins such as α-Synuclein (α-Syn) in Parkinson’s disease and Aβ42 in Alzheimer’s disease include primary nucleation, amyloid fibril elongation and secondary nucleation.
Externí odkaz:
https://doaj.org/article/90c928bc7c7542db836b296434e76fdf
Autor:
Piotr Klukowski, Fred F. Damberger, Frédéric H.-T. Allain, Hideo Iwai, Harindranath Kadavath, Theresa A. Ramelot, Gaetano T. Montelione, Roland Riek, Peter Güntert
Publikováno v:
Scientific Data, Vol 11, Iss 1, Pp 1-13 (2024)
Abstract Multidimensional NMR spectra are the basis for studying proteins by NMR spectroscopy and crucial for the development and evaluation of methods for biomolecular NMR data analysis. Nevertheless, in contrast to derived data such as chemical shi
Externí odkaz:
https://doaj.org/article/d607f976b6f94288a6a64321321d3e7a
Nuclear Magnetic Resonance (NMR) spectroscopy is one of the major techniques in structural biology with over 11,800 protein structures deposited in the Protein Data Bank. NMR can elucidate structures and dynamics of small and medium size proteins in
Externí odkaz:
http://arxiv.org/abs/2201.12041
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Chemical shift transfer (CST) is a well-established technique in NMR spectroscopy that utilizes the chemical shift assignment of one protein (source) to identify chemical shifts of another (target). Given similarity between source and target systems
Externí odkaz:
https://doaj.org/article/712c5a93076142b5bd6222f47d2d06f9
Autor:
S. Kuschert, M. Stroet, Y. K.-Y. Chin, A. C. Conibear, X. Jia, T. Lee, C. R. O. Bartling, K. Strømgaard, P. Güntert, K. J. Rosengren, A. E. Mark, M. Mobli
Publikováno v:
Magnetic Resonance, Vol 4, Pp 57-72 (2023)
Peptides and proteins containing non-canonical amino acids (ncAAs) are a large and important class of biopolymers. They include non-ribosomally synthesised peptides, post-translationally modified proteins, expressed or synthesised proteins containing
Externí odkaz:
https://doaj.org/article/18e1d51764ce4a1196fed029911b7277
Autor:
Juan A. Gerez, Natalia C. Prymaczok, Harindranath Kadavath, Dhiman Ghosh, Matthias Bütikofer, Yanick Fleischmann, Peter Güntert, Roland Riek
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
An improved method for in-cell NMR is developed using a reporter to evaluate protein delivery and delivery parameters to different cell lines and applied to IDPs and folded proteins including structure determination of GB1 at 1.1 Å resolution.
Externí odkaz:
https://doaj.org/article/cd54d82a635a4d768be4cf377bb68830
Autor:
Dzmitry Ashkinadze, Harindranath Kadavath, Aditya Pokharna, Celestine N. Chi, Michael Friedmann, Dean Strotz, Pratibha Kumari, Martina Minges, Riccardo Cadalbert, Stefan Königl, Peter Güntert, Beat Vögeli, Roland Riek
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
In this manuscript the authors report accurate multi-state protein structures of the PDZ domain using biological NMR. By looking into protein structural states, the authors report an allosteric pathway at atomic resolution that validates previously r
Externí odkaz:
https://doaj.org/article/6b3bc663eccc4bfea2bb66b7062c25de
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
The analysis of protein NMR spectra is time-consuming and can occupy a human expert for weeks or months. The researchers in this work present a deep learning-based method that delivers signal positions, chemical shift assignments, and structures of p
Externí odkaz:
https://doaj.org/article/5c71525a53e84fd580eb761d30340173
Akademický článek
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Publikováno v:
BMJ Open Quality, Vol 11, Iss 2 (2022)
Externí odkaz:
https://doaj.org/article/a01f5d335cb84105bfc3ad54c164c4f0