Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Günter Schwarzmann"'
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 3, Pp 563-577 (2017)
Glucosylceramide (GlcCer) is the primary storage lipid in the lysosomes of Gaucher patients and a secondary one in Niemann-Pick disease types A, B, and C. The regulatory roles of lipids on the hydrolysis of membrane bound GlcCer by lysosomal β-gluco
Externí odkaz:
https://doaj.org/article/67b6391b149c4207a5dc847549122bc9
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 10, Pp 1861-1879 (2015)
A Förster resonance energy transfer-based fusion and transfer assay was developed to study, in model membranes, protein-mediated membrane fusion and intermembrane lipid transfer of fluorescent sphingolipid analogs. For this assay, it became necessar
Externí odkaz:
https://doaj.org/article/7deb1920324449a4afd75c3b752915ba
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 9, Pp 1747-1761 (2015)
Ganglioside GM2 is the major lysosomal storage compound of Tay-Sachs disease. It also accumulates in Niemann-Pick disease types A and B with primary storage of SM and with cholesterol in type C. Reconstitution of GM2 catabolism with β-hexosaminidase
Externí odkaz:
https://doaj.org/article/b0702d18fa274f06b1872a7a0e4d1e7f
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 12, Pp 2692-2706 (2014)
Within recent years, ganglioside patterns have been increasingly analyzed by MS. However, internal standards for calibration are only available for gangliosides GM1, GM2, and GM3. For this reason, we prepared homologous internal standards bearing non
Externí odkaz:
https://doaj.org/article/71d361b15ab74f499e55110e27139470
Autor:
Misbaudeen Abdul-Hammed, Bernadette Breiden, Matthew A. Adebayo, Jonathan O. Babalola, Günter Schwarzmann, Konrad Sandhoff
Publikováno v:
Journal of Lipid Research, Vol 51, Iss 7, Pp 1747-1760 (2010)
We examined the effect of Niemann-Pick disease type 2 (NPC2) protein and some late endosomal lipids [sphingomyelin, ceramide and bis(monoacylglycero)phosphate (BMP)] on cholesterol transfer and membrane fusion. Of all lipid-binding proteins tested, o
Externí odkaz:
https://doaj.org/article/22717ad5958340a6b49e36aaa8ab0e5b
Metabolism of the unnatural anticancer lipid safingol, l-threo-dihydrosphingosine, in cultured cells
Autor:
Mihaela Dragusin, Cristian Gurgui, Günter Schwarzmann, Joerg Hoernschemeyer, Gerhild van Echten-Deckert
Publikováno v:
Journal of Lipid Research, Vol 44, Iss 9, Pp 1772-1779 (2003)
We studied the metabolism of radioactively labeled safingol (l-threo-dihydrosphingosine) in primary cultured neurons, B104 neuroblastoma cells, and Swiss 3T3 fibroblasts, and compared it to that of its natural stereoisomer d-erythro-dihydrosphingosin
Externí odkaz:
https://doaj.org/article/e546193b821c442faf9db6b30e0cde2f
Autor:
Marina Schmälzlein, Christian Heinlein, Konrad Sandhoff, Jose Nelson Lombana Sanchez, Markus Hessefort, Irene Boos, Bernadette Breiden, Christian Schulz, Clemens Steegborn, Lukas Perkams, Kerstin Ross, Manuel Mönnich, Christopher Günther Franz Graf, Carlo Unverzagt, Markus Püttner, Michael Weyand, Günter Schwarzmann
Publikováno v:
Angewandte Chemie. 129:5336-5341
The main glycoforms of the hydrophobic lysosomal glycoprotein saposin D (SapD) were synthesized by native chemical ligation. An approach for the challenging solid-phase synthesis of the fragments was developed. Three SapD glycoforms were obtained fol
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 3, Pp 563-577 (2017)
Glucosylceramide (GlcCer) is the primary storage lipid in the lysosomes of Gaucher patients and a secondary one in Niemann-Pick disease types A, B, and C. The regulatory roles of lipids on the hydrolysis of membrane bound GlcCer by lysosomal β-gluco
Autor:
Günter, Schwarzmann
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1949
For uncompromised in vitro assays for intermembrane lipid transfer and membrane fusion fluorescent membrane-spanning lipids have proved to be invaluable tools. These lipids in contrast to phosphoglycerolipids and sphingolipids are resistant to sponta
Autor:
Günter Schwarzmann
Publikováno v:
Methods in Molecular Biology ISBN: 9781493991358
For uncompromised in vitro assays for intermembrane lipid transfer and membrane fusion fluorescent membrane-spanning lipids have proved to be invaluable tools. These lipids in contrast to phosphoglycerolipids and sphingolipids are resistant to sponta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96c196cde40d98f5904d61d7590fb152
https://doi.org/10.1007/978-1-4939-9136-5_21
https://doi.org/10.1007/978-1-4939-9136-5_21