Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Günter Rambach"'
Autor:
Cornelia Speth, Ruben Bellotti, Georg Schäfer, Günter Rambach, Bernhard Texler, Gudrun C. Thurner, Dietmar Öfner, Cornelia Lass-Flörl, Manuel Maglione
Publikováno v:
Current Oncology, Vol 29, Iss 12, Pp 9833-9854 (2022)
Pancreatic ductal adenocarcinoma (PDAC) is still hampered by a dismal prognosis. A better understanding of the tumor microenvironment within the pancreas and of the factors affecting its composition is of utmost importance for developing new diagnost
Externí odkaz:
https://doaj.org/article/602fdd3901064a16b7ded8b62bd0bd00
Autor:
Luke D. Halder, Emeraldo A. H. Jo, Mohammad Z. Hasan, Marta Ferreira-Gomes, Thomas Krüger, Martin Westermann, Diana I. Palme, Günter Rambach, Niklas Beyersdorf, Cornelia Speth, Ilse D. Jacobsen, Olaf Kniemeyer, Berit Jungnickel, Peter F. Zipfel, Christine Skerka
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Extracellular vesicles can carry immunoregulatory cytokines such as TGF-β. Here the authors use CD11b-deficient mice and macrophages to show that such vesicles carrying TGF-β are produced in response to Candida albicans infections and can limit the
Externí odkaz:
https://doaj.org/article/100b9457afd440a39a41c6760279cbb2
Candida albicans Induces Cross-Kingdom miRNA Trafficking in Human Monocytes To Promote Fungal Growth
Autor:
Luke D. Halder, Svitlana Babych, Diana I. Palme, Elham Mansouri-Ghahnavieh, Lia Ivanov, Victory Ashonibare, Daniela Langenhorst, Bhupesh Prusty, Günter Rambach, Melissa Wich, Nora Trinks, Matthew G. Blango, Daniel Kornitzer, Ulrich Terpitz, Cornelia Speth, Berit Jungnickel, Niklas Beyersdorf, Peter F. Zipfel, Axel A. Brakhage, Christine Skerka
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT In response to infections, human immune cells release extracellular vesicles (EVs) that carry a situationally adapted cocktail of proteins and nucleic acids, including microRNAs (miRNAs), to coordinate the immune response. In this study, we
Externí odkaz:
https://doaj.org/article/66c93ab97dcd4f169fa55e314a6c98f3
Autor:
Verena Harpf, Günter Rambach, Nadia Parth, Magdalena Neurauter, Verena Fleischer, Michaela Lackner, Cornelia Lass-Flörl, Reinhard Würzner, Cornelia Speth
Publikováno v:
Journal of Fungi, Vol 9, Iss 2, p 162 (2023)
Background: Mucormycetes, a heterogeneous group of fungi, induce a life-threatening disease called mucormycosis. Immune deficiencies represent a major risk factor; hence, we wanted to illuminate the role of complement and platelets in the defense aga
Externí odkaz:
https://doaj.org/article/31a7b36862754f54af73846686e39b5e
Publikováno v:
Virulence, Vol 10, Iss 1, Pp 976-983 (2019)
Aspergillus spp and particularly the species Aspergillus fumigatus are the causative agents of invasive aspergillosis, a progressive necrotizing pneumonia that occurs in immunocompromised patients. The limited efficacy of currently available antifung
Externí odkaz:
https://doaj.org/article/76a090f1d06c46988d4c4bc517af97a6
Autor:
Silke Machata, Sravya Sreekantapuram, Kerstin Hünniger, Oliver Kurzai, Christine Dunker, Katja Schubert, Wibke Krüger, Bianca Schulze-Richter, Cornelia Speth, Günter Rambach, Ilse D. Jacobsen
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Murine infection models are widely used to study systemic candidiasis caused by C. albicans. Whole-blood models can help to elucidate host-pathogens interactions and have been used for several Candida species in human blood. We adapted the human whol
Externí odkaz:
https://doaj.org/article/c1ca1de9ff614e508fb95416a7ce81ba
Autor:
Cornelia Speth, Günter Rambach, Andrea Windisch, Magdalena Neurauter, Hans Maier, Markus Nagl
Publikováno v:
Journal of Fungi, Vol 8, Iss 5, p 535 (2022)
N-chlorotaurine (NCT) can be used topically as a well-tolerated anti-infective at different body sites. The aim of this study was to investigate the efficacy of inhaled NCT in a mouse model of fungal pneumonia. Specific pathogen-free female C57BL/6JR
Externí odkaz:
https://doaj.org/article/1d99fce6347c44328ab30fe21d8f43ca
Autor:
Hemalata Deshmukh, Cornelia Speth, Donald C. Sheppard, Magdalena Neurauter, Reinhard Würzner, Cornelia Lass-Flörl, Günter Rambach
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Invasive fungal infections caused by Aspergillus (A.) and Mucorales species still represent life-threatening diseases in immunocompromised individuals, and deeper knowledge about fungal interactions with elements of innate immunity, such as complemen
Externí odkaz:
https://doaj.org/article/cd3d07bbcf674052b87347c751e380fd
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Candida is a dominant fungal pathogen in immunocompromised hosts, leading to opportunistic infections. Complement with its multifaceted functions is involved in the immune defense against this yeast, and recently several novel aspects have emerged in
Externí odkaz:
https://doaj.org/article/20ceab453edd44969dd08baa338cd9d2
Autor:
Günter Rambach, Verena Fleischer, Verena Harpf, Michaela Lackner, Andreas Meinitzer, Hans Maier, Johannes Engesser, Cornelia Lass-Flörl, Cornelia Speth
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0234063 (2020)
Pathogenic mucormycetes induce diseases with considerable morbidity and mortality in immunocompromised patients. Virulence data comparing different Mucorales species and various underlying risk factors are limited. We therefore compared the pathogene
Externí odkaz:
https://doaj.org/article/cb66e13aa52c409b8cd3ced315eb9d7e