Zobrazeno 1 - 10
of 134
pro vyhledávání: '"Günter Krause"'
Autor:
Floyd Hassenrück, Maria Farina-Morillas, Lars Neumann, Francesco Landini, Stuart James Blakemore, Mina Rabipour, Juan Raul Alvarez-Idaboy, Christian P. Pallasch, Michael Hallek, Rocio Rebollido-Rios, Günter Krause
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Targeting the PI3K isoform p110δ against B cell malignancies is at the mainstay of PI3K inhibitor (PI3Ki) development. Therefore, we generated isogenic cell lines, which express wild type or mutant p110δ, for assessing the potency, isoform
Externí odkaz:
https://doaj.org/article/69f0d2808dd345ce9c545e0a14f5e38c
Autor:
Eric Günter Krause
Publikováno v:
Bankfachklasse. 44:8-11
Autor:
Clemens Pornschlegel, Eva Geulen, Anton Schütz, Florian Schneider, Helen Müller, Sabine Biebl, Günter Krause, Patrick Lang, Ania Mauruschat, Thorben Päthe, Herbert Holl
Asthetische Formen sind Kristallisationspunkte kultureller, religioser und politischer Konflikte. Dies gilt, sofern sie religios determinierten und legitimierten Bedeutungssystemen angehoren. Sie stehen im Horizont bestimmter Klassifikationsschemata,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdb4eade83b58ed45b822456af8d2612
https://doi.org/10.30965/9783846753118
https://doi.org/10.30965/9783846753118
Publikováno v:
Cancers
Cancers, Vol 12, Iss 2525, p 2525 (2020)
Cancers, Vol 12, Iss 2525, p 2525 (2020)
Cytokines are soluble protein factors with importance in intercellular communication and, as such, play pivotal roles in the pathogenesis of B cell malignancies. Evidence from in vitro cultures permitted us to choose example cytokines that bind to di
Autor:
Günter Krause
Alle ökonomischen Transaktionen werden durch Verträge, seien sie explizit oder implizit, legal oder illegal, geregelt. Dies wurde in der ökonomischen Theorie bis Ronald Coase vernachlässigt. Aufbauend auf seinem Werk, haben in den letzten 20 Jahr
Publikováno v:
Br J Pharmacol
BACKGROUND AND PURPOSE: Bruton's tyrosine kinase (BTK) plays a key role in B‐cell receptor signalling by regulating cell proliferation and survival in various B‐cell malignancies. Covalent low‐MW BTK kinase inhibitors have shown impressive clin
Publikováno v:
Drug Design, Development and Therapy
On the occasion of its recent approval for relapsed follicular lymphoma, we review the design and development of the pan-class I PI3K inhibitor copanlisib as a drug for the treatment of B-cell malignancies in comparison with other kinase inhibitors t
BIM Regulation Is BTK Dependent and Can be Targeted By Entospletinib in Ibrutinib Refractory Mutants
Autor:
René P. Zahedi, Laura Beckmann, Michael Hallek, Clarissa Dickhut, Lukas P. Frenzel, Günter Krause, Valeska Berg
Publikováno v:
Blood. 134:1765-1765
Ibrutinib is especially effective in CLL patients with unmutated IgHV (UM-CLL), although presence of unmutated IgHV is usually associated with poor clinical outcome and shorter PFS. Sustained BCR signaling is one major reason for this. The BCL2 prote
Autor:
Elisa Göckeritz, Sylvia Herter, Floyd Hassenrück, Verena Vondey, Safi Hasan Midda, Eva Knödgen, Lars Neumann, Günter Krause, Christian Klein, Michael Hallek
Publikováno v:
BioMed Research International, Vol 2018 (2018)
BioMed Research International
BioMed Research International
The antibody-dependent cell-mediated cytotoxicity (ADCC) of the anti-CD20 monoclonal antibodies (mAbs) rituximab and obinutuzumab against the cell line Raji and isolated CLL cells and its potential impairment by kinase inhibitors (KI) was determined
Autor:
Michael Hallek, Lars Neumann, Susan Kerwien, Thomas Landwehr, Ningshu Liu, Clemens M. Wendtner, Günter Krause, Christian Klein, Elisa Göckeritz, Verena Vondey, Lukas P. Frenzel, Marion Wigger, Michael Baumann
Publikováno v:
International Journal of Cancer. 137:2234-2242
Pharmacological inhibition of phosphatiylinositide-3-kinase (PI3K)-mediated signaling holds great promise for treating chronic lymphocytic leukemia (CLL). Therefore we assessed three structurally related PI3K inhibitors targeting the PI3K-δ isoform