Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Günter Cichon"'
Autor:
Susanne Herwig, Julia M. Adler, Daria Vladimirova, Jakob Trimpert, Jalid Sehouli, Günter Cichon
Publikováno v:
Vaccines, Vol 12, Iss 3, p 248 (2024)
During the COVID-19 pandemic, the early emergence of viral variants repeatedly undermined the effects of vaccination. Our aim here is to explore strategies for improving spike vaccine gene antigenicity by merging mutations from different variants of
Externí odkaz:
https://doaj.org/article/3cd5b0c233ae4bbb92fbbcc8550a71b6
Autor:
Jakob Trimpert, Susanne Herwig, Julia Stein, Daria Vladimirova, Julia M. Adler, Azza Abdelgawad, Theresa C. Firsching, Tizia Thoma, Jalid Sehouli, Klaus Osterrieder, Achim D. Gruber, Birgit Sawitzki, Leif Erik Sander, Günter Cichon
Publikováno v:
Viruses, Vol 13, Iss 11, p 2290 (2021)
With the exception of inactivated vaccines, all SARS-CoV-2 vaccines currently used for clinical application focus on the spike envelope glycoprotein as a virus-specific antigen. Compared to other SARS-CoV-2 genes, mutations in the spike protein gene
Externí odkaz:
https://doaj.org/article/b30d56503a0141bb824f2651c751f2d7
Autor:
Geraldine Nouailles, Julia M. Adler, Peter Pennitz, Stefan Peidli, Gustavo Teixeira Alves, Morris Baumgart, Judith Bushe, Anne Voss, Alina Langenhagen, Fabian Pott, Julia Kazmierski, Cengiz Goekeri, Szandor Simmons, Na Xing, Christine Langner, Ricardo Martin Vidal, Azza Abdelgawad, Susanne Herwig, Günter Cichon, Daniela Niemeyer, Christian Drosten, Christine Goffinet, Markus Landthaler, Nils Blüthgen, Haibo Wu, Martin Witzenrath, Achim D. Gruber, Samantha D. Praktiknjo, Nikolaus Osterrieder, Emanuel Wyler, Dusan Kunec, Jakob Trimpert
Vaccines are a cornerstone in COVID-19 pandemic management. Here, we compare immune responses to and preclinical efficacy of the mRNA vaccine BNT162b2, an adenovirus-vectored spike vaccine, and the live-attenuated-virus vaccine candidate sCPD9 after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98b0dc6876e31b59e9b8dcc55a0c9db8
https://doi.org/10.1101/2022.05.16.492138
https://doi.org/10.1101/2022.05.16.492138
Autor:
Jalid Sehouli, Susanne Herwig, Jakob Trimpert, Achim D. Gruber, Tizia Thoma, Leif E. Sander, Julia Adler, Günter Cichon, Julia Stein, Birgit Sawitzki, Daria Vladimirova, Theresa C. Firsching, Azza Abdelgawad, Klaus Osterrieder
Publikováno v:
Viruses
Volume 13
Issue 11
Viruses, Vol 13, Iss 2290, p 2290 (2021)
Volume 13
Issue 11
Viruses, Vol 13, Iss 2290, p 2290 (2021)
With the exception of inactivated vaccines, all SARS-CoV-2 vaccines currently used for clinical application focus on the spike envelope glycoprotein as a virus-specific antigen. Compared to other SARS-CoV-2 genes, mutations in the spike protein gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc87464007ffda2f2ecfa7986bc7ffb7
https://doi.org/10.17169/refubium-33486
https://doi.org/10.17169/refubium-33486
Publikováno v:
Archives of Gynecology and Obstetrics
Purpose The cell surface glycoprotein Mesothelin is overexpressed in ovarian, fallopian tube, endometrial, cervical and primary peritoneal cancer and, therefore, might become a particular interesting tumor target in gynecologic oncology. However, eve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e3d4329588b3ee923eb3a5364f2adfd
https://refubium.fu-berlin.de/handle/fub188/35633
https://refubium.fu-berlin.de/handle/fub188/35633
Autor:
C. Schaefer, Achim D. Gruber, Jalid Sehouli, Jana Barinoff, Lea Lazzerini, J. Hoppe, Roland Bücker, Günter Cichon
Publikováno v:
Pharmaceutical research. 36(1)
The identification of novel cell lines which combine the most important properties of mucosal membranes in terms of drug absorption, transmembrane transport and mucus secretion can help to establish improved and meaningful test systems for pharmacolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6940a347876dcf6d012f6eaac50615ee
https://pubmed.ncbi.nlm.nih.gov/30411161
https://pubmed.ncbi.nlm.nih.gov/30411161
Autor:
Corinna Hoffmann, Günter Cichon, Jonas Stanke, Andreas M. Kaufmann, Achim Schneider, Christoph Loddenkemper
Publikováno v:
Journal of Immunotherapy. 33:136-145
We generated an adenovirus-based T-cell vaccine (Ad-p14) that reliably elicits T-cell responses to human papillomavirus (HPV) oncogenes of the 2 most common high-risk HPV serotypes. The artificial gene used to create the vaccine comprising 415 aa (12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d69a52ac93f881da71d627c364e4b4
https://doi.org/10.1097/cji.0b013e3181badc46
https://doi.org/10.1097/cji.0b013e3181badc46
Autor:
Udo Baron, Harald Stein, Corinna Hoffmann, Sven Olek, Achim Schneider, Christoph Loddenkemper, Andreas M. Kaufmann, Joerg-Peter Ritz, Jochen Huehn, Günter Cichon, Dirk Nagorsen, Jonas Stanke
Publikováno v:
Cancer Science. 100:1112-1117
Regulatory (FOXP3+) T cells (Tregs) comprise a subpopulation of CD4+ T cells that suppress autoreactive immune cells, thereby protecting organs and tissues from autoimmunity. Tregs have also been detected in human malignancies and their depletion or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1beabd861050eb88fb141eceb00437f
https://doi.org/10.1111/j.1349-7006.2009.01153.x
https://doi.org/10.1111/j.1349-7006.2009.01153.x
Autor:
Corinna, Hoffmann, Christopher, Bachran, Jonas, Stanke, Sefer, Elezkurtaj, Andreas M, Kaufmann, Hendrik, Fuchs, Hendrick, Fuchs, Christoph, Loddenkemper, Achim, Schneider, Günter, Cichon
Publikováno v:
Gynecologic oncology. 118(1)
Objective Most of primary human cancer tissues show effective engraftment and proliferation after transplantation onto Scid mice. However xenotransplantation of vital specimens of cervical carcinoma has not been successful in the past, also the gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c08f1beb2ae495db7a5432e186ece4b
https://pubmed.ncbi.nlm.nih.gov/20441999
https://pubmed.ncbi.nlm.nih.gov/20441999
Autor:
Hartmut Schmidt, Regina Haas, Günter Cichon, Tahar Benhidjeb, Sabine Ziemer, Michael P. Manns, Jörg Heeren, Michael Strauss, Nicole Grewe, Peter M. Schlag, Peter Löser, Frank Schnieders
Publikováno v:
The journal of gene medicine. 1(5)
Background Recombinant adenoviruses are highly efficient gene transfer vehicles but their administration to mammals is accompanied by a strong inflammatory response. The present study reports additional side effects observed during adenoviral gene tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27f080cf91274abbde381610f074a14e
https://pubmed.ncbi.nlm.nih.gov/10738553
https://pubmed.ncbi.nlm.nih.gov/10738553