Zobrazeno 1 - 10 of 115 pro vyhledávání: '"Gündel D"'
1
Akademický článek
Endocytotic uptake of HPMA-based polymers by different cancer cells: impact of extracellular acidosis and hypoxia
Autor: Gündel D, Allmeroth M, Reime S, Zentel R, Thews O
Publikováno v: International Journal of Nanomedicine, Vol Volume 12, Pp 5571-5584 (2017)
Daniel Gündel,1 Mareli Allmeroth,2 Sarah Reime,1 Rudolf Zentel,2 Oliver Thews1 1Institute of Physiology, Martin Luther University Halle-Wittenberg, Halle (Saale), 2Institute of Organic Chemistry, Johannes Gutenberg-University, Mainz, Germany Backgro
Externí odkaz: https://doaj.org/article/cf2ffc780cd54db3ad82b9bb4bfa8bfe
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2
Akademický článek
Intracochlear PLGA based implants for dexamethasone release: Challenges and solutions
Autor: Lehner, E., Gündel, D., Liebau, A., Plontke, S., Mäder, K.
Publikováno v: In International Journal of Pharmaceutics: X December 2019 1
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3
In vitro assessment of [¹⁸F]JHU94620-d8 to determine the expression of cannabinoid receptor 2 – a prognostic biomarker in breast cancer
Autor: Heerklotz, A., Moldovan, R.-P., Bormans, G., Pietzsch, J., Belter, B., Kopka, K., Gündel, D.
Publikováno v: EMIM 2023-European Molecular Imaging Meeting, 14.-17.03.2023, Salzburg, Österreich
The cannabinoid receptor 2 (CB2R) is involved in inflammatory processes [1], whereby an increased expression correlates with malignancy in various cancer types like human epidermal growth receptor 2 positive (HER2+) or triple negative breast cancer (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::1a6143ab816688b9e1c0a42aefba4b1b
https://www.hzdr.de/publications/Publ-35439-2
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4
[18F]FLUDA – A promising PET probe for the non-invasive assessment of the A2A adenosine receptor
Autor: Lai, T. H., Toussaint, M., Gündel, D., Dukic-Stefanovic, S., Teodoro, R., Sattler, B., Wenzel, B., Schröder, S., Moldovan, R.-P., Sabri, O., Brust, P., Kopka, K., Deuther-Conrad, W.
Publikováno v: iSRS 2023-25th International Symposium of Radiopharmaceutical Sciences, 22.-26.05.2023, Honolulu, Hawaii
Introduction: The A2A adenosine receptor (A2AAR) is expressed in brain, vasculature and immune cells. According to the alterations of the A2AAR expression in multiple diseases, it is a highly attractive diagnostic and therapeutic target. We developed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::52680b5cabdbcb999395aefb1eaed989
https://www.hzdr.de/publications/Publ-35899-1
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5
Data publication: Enantioselective Synthesis, Structure Activity Relationship, Radiofluorination and Biological Evaluation of [18F]RM365, a Novel Radioligand for Imaging the Human Cannabinoid Receptor Type 2 (CB2R) in the Brain with PET
Autor: Teodoro, R., Gündel, D., Deuther-Conrad, W., Toussaint, M., Wenzel, B., Bormans, G., Kopka, K., Brust, P., Moldovan, R.-P.
Publikováno v: Publication date: 2023-04-05 Open accessDOI: 10.14278/rodare.2251Versions: 10.14278/rodare.2252License: CC-BY-4.0
The development of cannabinoid receptor type 2 (CB2R) PET radioligands has been intensively explored due to the pronounced CB2R upregulation in various pathological conditions, such as neuroinflammation and cancer. Herein we report on the enantiosele
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::81c719fa7ae9f22edd3ded1c08e5a968
https://www.hzdr.de/publications/Publ-36778-1
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6
Development of the High-Affinity Carborane-Based Cannabinoid Receptor Type 2 PET Ligand [18F]LUZ5-d8
Autor: Ueberham, L., Gündel, D., Kellert, M., Deuther-Conrad, W., Ludwig, F.-A., Lönnecke, P., Kazimir, A., Kopka, K., Brust, P., Moldovan, R.-P., Hey-Hawkins, E.
Publikováno v: Journal of Medicinal Chemistry 66(2023), 5242-5260
The development of cannabinoid receptor type 2 (CB2R) radioligands for positron emission tomography (PET) imaging was intensively explored. To overcome the low metabolic stability and simultaneously increase the binding affinity of known CB2R radioli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::a9b3e509e287b33978e76964c9a26ff0
https://www.hzdr.de/publications/Publ-36975-1
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7
Structure-Based Design, Optimization and Development of [18F]LU13, a novel radioligand for CB2R Imaging in the Brain with PET
Autor: Gündel, D., Deuther-Conrad, W., Ueberham, L., Kaur, S., Otikova, E., Teodoro, R., Lai, T. H., Clauß, O., Scheunemann, M., Bormans, G., Bachmann, M., Kopka, K., Brust, P., Moldovan, R.-P.
Publikováno v: Journal of Medicinal Chemistry 65(2022)13, 9034-9049
The cannabinoid receptor type 2 (CB2R) is an attractive target for diagnosis and therapy of neurodegenerative diseases and cancer. Recently, we reported a novel naphthyrid-2-one based positron-emission tomography (PET) radioligand for imaging of the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::8c3875da3c61ce5c8eef8ff8cfb092f1
https://www.hzdr.de/publications/Publ-33987-1
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8
First evaluation of [18F]RM273 for sigma2 receptor imaging in a pre-clinical brain tumour model
Autor: Gündel, D., Toussaint, M., Moldovan, R.-P., Teodoro, R., Schepmann, D., Wünsch, B., Ludwig, F.-A., Fischer, S., Brust, P., Deuther-Conrad, W.
Publikováno v: EMIM 2022, 15.-18.03.2022, Thessaloniki, Greece
Introduction: The sigma2 receptor (TMEM97) expression correlates well with the Ki67 expression in tumours [1, 2] and therefore represents an attractive marker for the proliferative status. An assessment of the sigma2 receptors in brain tumours by a n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::5e9229d1b5f8407b4d0a81d876069407
https://www.hzdr.de/publications/Publ-33507-2
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9
Development and Biological Evaluation of the First Highly Potent and Specific Benzamide-Based Radiotracer [¹⁸F]BA3 for Imaging of Histone Deacetylases 1 and 2 in Brain
Autor: Clauß, O., Schäker-Hübner, L., Wenzel, B., Toussaint, M., Deuther-Conrad, W., Gündel, D., Teodoro, R., Dukic-Stefanovic, S., Ludwig, F.-A., Kopka, K., Brust, P., Hansen, F. K., Scheunemann, M.
Publikováno v: Pharmaceuticals 15(2022)3, 324
The degree of acetylation of lysine residues on histones influences the accessibility of DNA and, furthermore, the gene expression. Histone deacetylases (HDACs) are overexpressed in various tumour diseases, resulting in the interest in HDAC inhibitor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4577::b37260a3269c50f84ab98d73c1f5ea5c
https://www.hzdr.de/publications/Publ-34169-1
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10
Investigation of the Cannabinoid Receptor 2 (CB2R) Expression and Preliminary In Vitro Evaluation of the CB2R Specific PET Radioligand [18F]JHU94620-d8 in Different Breast Cancer Models
Autor: Heerklotz, A., Moldovan, R.-P., Deuther-Conrad, W., Bormans, G., Pietzsch, J., Belter, B., Kopka, K., Gündel, D.
Publikováno v: MOBI 2022, 15.-16.09.2022, Leipzig, Deutschland
5th GyMICMolecular Imaging Symposium, 15.-16.09.2022, Leipzig, Deutschland
Introduction The cannabinoid receptor 2 (CB2R) is involved in inflammatory processes [1], whereby an increased expression correlates with malignancy in various cancer types like human epidermal growth receptor 2 positive (HER2+) or triple negative br
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::42096d48ed76b097374756dffd4c1224
https://www.hzdr.de/publications/Publ-34950-2
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