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pro vyhledávání: '"Güliz Gürel Özcan"'
Autor:
Güliz Gürel Özcan, Sumi Lim, Thomas Canning, Lavitasha Tirathdas, Joshua Donnelly, Tanushree Kundu, Jason Rihel
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108870- (2024)
Summary: Amyloid precursor protein (APP) is a brain-rich, single pass transmembrane protein that is proteolytically processed into multiple products, including amyloid-beta (Aβ), a major driver of Alzheimer disease (AD). Although both overexpression
Externí odkaz:
https://doaj.org/article/7ee08a28fe0147358c2e4d01951b38c9
Publikováno v:
eLife, Vol 9 (2020)
Disrupted sleep is a major feature of Alzheimer’s disease (AD), often arising years before symptoms of cognitive decline. Prolonged wakefulness exacerbates the production of amyloid-beta (Aβ) species, a major driver of AD progression, suggesting t
Externí odkaz:
https://doaj.org/article/c72228ea01c84b2a90655b15557d3e1b
Sleep-wake disturbances are among the earliest symptoms of Alzheimer’s disease (AD) and contribute to disease severity. Since a major driver of AD—the accumulation of amyloid-beta (Aβ) in the brain—is modulated by sleep, a “vicious” feedfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8943be2fe03940b72eb119b563c6beb4
https://doi.org/10.1101/2022.06.08.495312
https://doi.org/10.1101/2022.06.08.495312
Publikováno v:
eLife
eLife, Vol 9 (2020)
eLife, Vol 9 (2020)
SUMMARYDisrupted sleep is a major feature of Alzheimer’s Disease (AD), often arising years before symptoms of cognitive decline. Prolonged wakefulness exacerbates the production of amyloid-beta (Aβ) species, a major driver of AD progression, sugge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6760f666e1b45f0aad2beb98475e381e
Autor:
Jason Rihel, Güliz Gürel Özcan
Publikováno v:
Neuron
Summary Sleep is under homeostatic control, but the mechanisms that sense sleep need and correct sleep deficits remain unknown. Here, we report that sleep-promoting neurons with projections to the dorsal fan-shaped body (FB) form the output arm of Dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40dacb92f3ea0d9abf04d7b4da55d0dc