Absence of mitochondrial SLC25A51 enhances PARP1-dependent DNA repair by increasing nuclear NAD⁺ levels.

Autor: Güldenpfennig, Anka, Hopp, Ann-Katrin, Muskalla, Lukas, Manetsch, Patrick, Raith, Fabio, Hellweg, Lars, Dördelmann, Cyril, Leslie Pedrioli, Deena M, Johnsson, Kai, Superti-Furga, Giulio, Hottiger, Michael O

Publikováno v: Nucleic Acids Research; 9/22/2023, Vol. 51 Issue 17, p9248-9265, 18p

Absence of mitochondrial SLC25A51 enhances PARP1-dependent DNA repair by increasing nuclear NAD+ levels.

Autor: Güldenpfennig A; Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, 8057 Zurich, Switzerland.; Life Science Zurich Graduate School, Molecular Life Science Ph.D. Program, University of Zurich, 8057 Zurich, Switzerland., Hopp AK; Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, 8057 Zurich, Switzerland.; Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Science, 1090 Vienna, Austria., Muskalla L; Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, 8057 Zurich, Switzerland.; Life Science Zurich Graduate School, Cancer Biology Ph.D. Program, University of Zurich, 8057 Zurich, Switzerland., Manetsch P; Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, 8057 Zurich, Switzerland.; Life Science Zurich Graduate School, Molecular Life Science Ph.D. Program, University of Zurich, 8057 Zurich, Switzerland., Raith F; Department of Chemical Biology, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany., Hellweg L; Department of Chemical Biology, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany., Dördelmann C; Life Science Zurich Graduate School, Cancer Biology Ph.D. Program, University of Zurich, 8057 Zurich, Switzerland.; Institute of Molecular Cancer Research (IMCR), University of Zurich, 8057 Zurich, Switzerland., Leslie Pedrioli DM; Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, 8057 Zurich, Switzerland., Johnsson K; Department of Chemical Biology, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany.; Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL) Lausanne, 1015 Lausanne, Switzerland., Superti-Furga G; Research Center for Molecular Medicine (CeMM) of the Austrian Academy of Science, 1090 Vienna, Austria.; Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria., Hottiger MO; Department of Molecular Mechanisms of Disease (DMMD), University of Zurich, 8057 Zurich, Switzerland.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2023 Sep 22; Vol. 51 (17), pp. 9248-9265.