Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Gösta Winberg"'
Autor:
Simone Picelli, Gösta Winberg, Rickard Sandberg, Åsa K. Björklund, Björn Reinius, Sven Sagasser
Publikováno v:
Genome Research
Massively parallel DNA sequencing of thousands of samples in a single machine-run is now possible, but the preparation of the individual sequencing libraries is expensive and time-consuming. Tagmentation-based library construction, using the Tn5 tran
Autor:
Rickard Sandberg, Gösta Winberg, Simone Picelli, Omid R. Faridani, Sven Sagasser, Åsa K. Björklund
Publikováno v:
Nature Protocols
Emerging methods for the accurate quantification of gene expression in individual cells hold promise for revealing the extent, function and origins of cell-to-cell variability. Different high-throughput methods for single-cell RNA-seq have been intro
Publikováno v:
Archives of Virology. 158:1433-1443
Up to now, seven viruses that infect humans have been identified as oncogenic and are closely associated with different human cancers. Most of them encode oncogenes whose products play important roles in the development of cancers in the context of e
Autor:
Gösta Winberg, C Helmstetter, R J Ingham, Gerald D. Gish, Tony Pawson, C K Lindholm, Liudmila Matskova, Ingemar Ernberg
Publikováno v:
Oncogene. 26:4908-4917
The Epstein-Barr virus latency-associated membrane protein LMP2A has been shown to activate the survival kinase Akt in epithelial and B cells in a phosphoinositide 3-kinase-dependent fashion. In this study, we demonstrate that the signalling scaffold
Publikováno v:
Vaccine. 24:4572-4575
C57BL/6 and BALB/c mice were immunized with two different plasmids (p91023B and pKCEA66) encoding different forms of the tumor-associated antigen carcinoembryonic antigen (CEA). The wild type form of CEA (p91023B), which is expressed at the cell surf
Autor:
Sven Sagasser, Gösta Winberg, Rickard Sandberg, Omid R. Faridani, Åsa K. Björklund, Simone Picelli
Publikováno v:
Nature Methods
Single-cell gene expression analyses hold promise for characterizing cellular heterogeneity, but current methods compromise on either the coverage, the sensitivity or the throughput. Here, we introduce Smart-seq2 with improved reverse transcription,
Autor:
Gösta Winberg, Lev L. Kisselev, Eugene R. Zabarovsky, Jingfeng Li, Eleonora A. Braga, George Klein, John D. Minna, Alena Malyukova, Michael I. Lerman, Igor Kuzmin, Elena Kadyrova, Veronika I. Zabarovska, Alexander V. Zelenin, Olga V. Muravenko, Vladimir I. Kashuba, A.I. Protopopov, V. N. Senchenko, Alexey S. Kutsenko, Fuli Wang, Ingemar Ernberg
Publikováno v:
Proceedings of the National Academy of Sciences. 101:4906-4911
Chromosome 3p21.3 region is frequently (>90%) deleted in lung and other major human carcinomas. We subdivided 3p21.3 into LUCA and AP20 subregions and discovered frequent homozygous deletions (10-18%) in both subregions. This finding strongly implies
Publikováno v:
Biological Cybernetics. 88:20-32
The concerted and self-organizing behavior of spinal cord segments in generating locomotor patterns is modulated by afferent sensory information and controlled by descending pathways from the brainstem, cerebellum, or cortex. The purpose of this stud
Autor:
Eugene R. Zabarovsky, Gösta Winberg, Jinfeng Li, George Klein, Alexei Protopopov, Vladimir I. Kashuba, R. Z. Gizatullin
Publikováno v:
The Journal of Gene Medicine. 4:397-406
Background We modified a tetracycline-regulated system that can control the activity of individual genes quantitatively and reversibly in transgenic mammals. Despite these advances, there remained one problem in the intensive use of the tet-system: t
Publikováno v:
Journal of Virology. 75:10941-10949
The latency-regulated transmembrane protein LMP2A interferes with signaling from the B-cell antigen receptor by recruiting the tyrosine kinases Lyn and Syk and by targeting them for degradation by binding the cellular E3 ubiquitin ligase AIP4. It has