Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Gösta Hiller"'
Autor:
Can Slivo, Jonas Malmström, Mervi Vasänge, Mickaël Maudet, Stefan Geschwindner, Gösta Hiller, Yafeng Xue, Jenny Viklund, Catrin Sandelin, Lise-Lotte Olsson, Ana Rodrigues Costa, Anna Aagaard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5919-5923
4-(1,3-Benzothiazol-2-yl)thiophene-2-sulfonamide (4a) was found to be a moderately potent inhibitor of cyclin-dependent kinase 5 (cdk5) from a HTS screen. The synthesis and SAR around this hit is described. The X-ray coordinates of ligand 4a with cdk
Autor:
Roger Sundler, Gösta Hiller
Publikováno v:
Cellular Signalling. 14:169-173
Phospholipase C-gamma (PLC-gamma) isoforms are thought to be activated by both tyrosine phosphorylation and phosphatidylinositol 3,4,5 trisphosphate (PtdIns 3,4,5 P(3)), the product of phosphatidylinositol 3-kinase (PtdIns 3-kinase). In this study, w
Publikováno v:
Biochemical Pharmacology. 60:545-551
In mouse macrophages, arachidonate mobilisation in response to several stimuli is severely inhibited by prolonged (16-20 hr) treatment with nanomolar dexamethasone (dex). It was shown earlier that this inhibition was accompanied by a dual effect on c
Autor:
Roger Sundler, Gösta Hiller
Publikováno v:
Cellular Signalling. 11:863-869
The mitogen-activated protein kinases (MAP kinases), extracellular signal-regulated kinase (ERK) and p38, can both contribute to the activation of cytosolic phospholipase A2 (cPLA2). We have investigated the hypothesis that ERK and p38 together or in
Autor:
Gösta Hiller, Jan Ottervald, Gang Liu, Ann-Cathrin Radesäter, Mervi Vasänge, Karin Agerman, Anne Jämsä, Jonas Malmström
Publikováno v:
Journal of Biomedical Science
Journal of Biomedical Science, Vol 16, Iss 1, p 55 (2009)
Journal of Biomedical Science, Vol 16, Iss 1, p 55 (2009)
Background Deregulated activation of cyclin-dependent kinase-5 (Cdk5) is implicated in neurodegenerative disorders such as Alzheimer's disease. One of the restricting factors for developing specific Cdk5 inhibitors is the lack of reproducible and wel
Glutamate treatment and p25 transfection increase Cdk5 mediated tau phosphorylation in SH-SY5Y cells
Autor:
Nodi Dehvari, Anders Bäckström, Elin Gustafsson, Richard F. Cowburn, Gösta Hiller, Anne Jämsä, Mervi Vasänge
Publikováno v:
Biochemical and biophysical research communications. 345(1)
Neurofibrillary tangles (NFT) of hyperphosphorylated tau protein are a major pathological hallmark of Alzheimer’s disease (AD). One of the tau phosphorylating kinases with pathological relevance in AD has been suggested to be the cyclin-dependent k
Publikováno v:
Biochimica et biophysica acta. 1485(2-3)
Stimulation of mouse peritoneal macrophages with zymosan or bacteria results in activation of 85-kDa cytosolic phospholipase A(2) (cPLA(2)) and release of arachidonate. We have investigated the role of phosphatidylinositol 3-kinase (PtdIns 3-kinase)