Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Gösta Hallström"'
Autor:
Vinayak P. Hosagrahara, Gösta Hallström, Per H. Svensson, Andrew S. Wells, Chungang Gu, Richard J. Lewis, Eskil Johnsson
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 43(10)
This study focused on the mechanistic interpretation of ex vivo oxidation of a candidate drug in blood plasma samples. An unexpected lipid peroxide-mediated epoxidation followed by a dramatic rearrangement led to production of a five-membered oxazole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdeba28eb197c588e9fe2475b2ea62db
https://pubmed.ncbi.nlm.nih.gov/26203069
https://pubmed.ncbi.nlm.nih.gov/26203069
Publikováno v:
Tetrahedron Letters. 21:667-670
Prop-2-ynylic N-oxides rearrange thermally via O-allenyl hydroxylamines to acrolein and an imine. The second rearrangement step, falling in the class of thermal cis -eliminations, is shown with variously 2 H-substituted pargyline N-oxides.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3481bbbab1ac1ccd0aa25e2c8310e7b
https://doi.org/10.1016/s0040-4039(01)85588-x
https://doi.org/10.1016/s0040-4039(01)85588-x
Publikováno v:
Xenobiotica. 11:459-471
1. Four non-acidic primary metabolites of N-(5-pyrrolidinopent-3-ynyl)succinimide (BL 14) were identified and quantified using g.l.c. and mass spectrometry. The metabolites are alpha-hydroxy-N-(5-pyrrolidinopent-3-ynyl)succinimide (A), N-(5-(2-oxopyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ebd6e90af1b1528e49deeaee970b9ab
https://doi.org/10.3109/00498258109045856
https://doi.org/10.3109/00498258109045856
Autor:
Gösta Hallström, Björn Lindeke
Publikováno v:
Biological Mass Spectrometry. 8:514-520
On gas chromatographic analysis, N-(5-pyrrolidinopent-3-ynyl)succinimide N'-oxide gave rise to three main decomposition products, which were assigned the structures N-(3-oxopent-4-enyl)succinimide, N-(penta-3, 4-dienyl)succinimide and N-3(3-pyrrolidi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a3762788915ad78aead4c70f6ff9cf6
https://doi.org/10.1002/bms.1200081010
https://doi.org/10.1002/bms.1200081010
Autor:
Örjan Ericsson, Björn Lindeke, Signhild Strömberg, Gösta Hallström, Lars-Inge Olsson, Carin E. Johansson
Publikováno v:
Biomedical mass spectrometry. 8(10)
Oxybutynin is rapidly metabolized in rat liver microsomes. Two major primary oxidation products were identified as N-desethyl oxybutynin and oxybutynin N-oxide. Deuterium substituted substrate was used to aid the identification. N-Desethyl oxybutynin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2dda3842dfa74bf54e4484bbc849f38
https://pubmed.ncbi.nlm.nih.gov/7295876
https://pubmed.ncbi.nlm.nih.gov/7295876
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 8(6)
1. The product of alpha-acetylenic oxidation of N-(5-pyrrolidinopent-3-ynyl)-succinimide (BL 14) by rat liver preparations was identified as N-(5-pyrrolidino-2-hydroxypent-3-ynyl)succinimide, by mass spectral analysis of metabolites of deuterium-labe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004427611f9c08ef565c98c16910f75e
https://pubmed.ncbi.nlm.nih.gov/676341
https://pubmed.ncbi.nlm.nih.gov/676341
Publikováno v:
J. Chem. Soc., Chem. Commun.. :9-10
Rearrangement of N-prop-2-ynylpiperidine N-oxide and N-prop-2-ynylmorpholine N-oxide to the corresponding O-allenyl hydroxylamines is reported; this rearrangement appears to be intramolecular proceeding by a cyclic mechanism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ca21479d8812d4e3a98716e27deb343
https://doi.org/10.1039/c39790000009
https://doi.org/10.1039/c39790000009