Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21.

Autor: Göricke F; Research & Development, Pharmaceuticals, Bayer AG, 42096 Wuppertal, Germany., Vu V; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Smith L; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Scheib U; Nuvisan Innovation Campus Berlin, 13353 Berlin, Germany., Böhm R; Nuvisan Innovation Campus Berlin, 13353 Berlin, Germany., Akkilic N; Nuvisan Innovation Campus Berlin, 13353 Berlin, Germany., Wohlfahrt G; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany., Weiske J; Nuvisan Innovation Campus Berlin, 13353 Berlin, Germany., Bömer U; Nuvisan Innovation Campus Berlin, 13353 Berlin, Germany., Brzezinka K; Nuvisan Innovation Campus Berlin, 13353 Berlin, Germany., Lindner N; Research & Development, Pharmaceuticals, Bayer AG, 42096 Wuppertal, Germany., Lienau P; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany., Gradl S; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany., Beck H; Research & Development, Pharmaceuticals, Bayer AG, 42096 Wuppertal, Germany., Brown PJ; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Santhakumar V; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Vedadi M; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Barsyte-Lovejoy D; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Arrowsmith CH; Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada., Schmees N; Nuvisan Innovation Campus Berlin, 13353 Berlin, Germany., Petersen K; Research & Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2023 Mar 09; Vol. 66 (5), pp. 3431-3447. Date of Electronic Publication: 2023 Feb 20.

Phosphoric Acid Catalyzed Formation of Hydrogen-Bonded o -Quinone Methides. Enantioselective Cycloaddition with β-Dicarbonyl Compounds toward Benzannulated Oxygen Heterocycles.

Autor: Göricke F; Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany., Haseloff S; Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany., Laue M; Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany., Schneider M; Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany., Brumme T; Wilhelm-Ostwald-Institut für Physikalische und Theoretische Chemie, Linnéstraße 2, 04103 Leipzig, Germany.; Theoretische Chemie, Technische Universität Dresden, Bergstraße 66c, 01062 Dresden, Germany., Schneider C; Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany.

Publikováno v: The Journal of organic chemistry [J Org Chem] 2020 Sep 18; Vol. 85 (18), pp. 11699-11720. Date of Electronic Publication: 2020 Aug 26.

Palladium-Catalyzed Enantioselective Addition of Chiral Metal Enolates to In Situ Generated ortho-Quinone Methides.

Autor: Göricke F; Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, 04103, Leipzig, Germany., Schneider C; Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, 04103, Leipzig, Germany.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2018 Nov 05; Vol. 57 (45), pp. 14736-14741. Date of Electronic Publication: 2018 Oct 18.

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Design and Application of m‐Hydroxybenzyl Alcohols in Regioselective (3 + 3) Cycloadditions of 2‐Indolymethanols^†.

Autor: Shi, Yi‐Cheng¹, Yan, Xin‐Yu¹, Wu, Ping¹, Jiang, Song¹, Xu, Ran¹, Tan, Wei¹ wtan@jsnu.edu.cn, Shi, Feng^1,2 fshi@cczu.edu.cn

Publikováno v: Chinese Journal of Chemistry. Jan2023, Vol. 41 Issue 1, p27-36. 10p.