Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish

Autor: Divine-Fondzenyuy Lawir, Cristian Soza-Ried, Norimasa Iwanami, Iliana Siamishi, Göran O. Bylund, Connor O´Meara, Katarzyna Sikora, Benoît Kanzler, Erik Johansson, Michael Schorpp, Pierre Cauchy, Thomas Boehm

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-18 (2024)

Abstract The stability of cellular phenotypes in developing organisms depends on error-free transmission of epigenetic and genetic information during mitosis. Methylation of cytosine residues in genomic DNA is a key epigenetic mark that modulates gen

Externí odkaz: https://doaj.org/article/157305a4e0ba4667992f767ee78c7835

Mechanism of suppression of chromosomal instability by DNA polymerase POLQ.

Autor: Matthew J Yousefzadeh, David W Wyatt, Kei-Ichi Takata, Yunxiang Mu, Sean C Hensley, Junya Tomida, Göran O Bylund, Sylvie Doublié, Erik Johansson, Dale A Ramsden, Kevin M McBride, Richard D Wood

Publikováno v: PLoS Genetics, Vol 10, Iss 10, p e1004654 (2014)

Although a defect in the DNA polymerase POLQ leads to ionizing radiation sensitivity in mammalian cells, the relevant enzymatic pathway has not been identified. Here we define the specific mechanism by which POLQ restricts harmful DNA instability. Ou

Externí odkaz: https://doaj.org/article/4231e2dcb1ae482db01a1c9297868d19

Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence

Autor: Verena Königer, D. Scott Merrell, Roman Andriiovych Moskalenko, Rainer Haas, Thomas Borén, Sara Henriksson, Jafar Mahdavi, Abhijit Chowdhury, Johan Ögren, Anders Hofer, Jay V. Solnick, Dan Danielsson, Sara K. Lindén, Dag Ilver, Konstantinos S. Papadakos, Susanne Vikström, Jörgen Ådén, Jan Holgersson, Gerhard Gröbner, Alexej Schmidt, Jeanna Bugaytsova, Oscar Björnham, Göran O. Bylund, Rolf Sjöström, Stefan Oscarson, Dionyssios N. Sgouras, Lori M. Hansen, Yevgen A Chernov, Anders Esberg, Kristof Moonens, Christopher Aisenbrey, Charles Kelly, Ludmilla A. Morozova-Roche, Jeannette M. Whitmire, Beatriz Martinez-Gonzalez, Asish K. Mukhopadhyay, Angela Eldridge, Nicklas Strömberg, Robert H. Gilman, Andre Dubois, Lars Engstrand, Staffan Schedin, Brett A. Chromy, Justine Younson, Matthew Goldman, Anna Shevtsova, Macarena P. Quintana-Hayashi, Hui Liu, Magnus Unemo, Lena Rakhimova, Anna Åberg, Sebastian Suerbaum, Anna Arnqvist, Pär Gideonsson, Maréne Landström, Douglas E. Berg, Kristoffer Brännström, Anders Olofsson, Melissa Mendez, G. Balakrish Nair, Han Remaut

Publikováno v: Cell Host and Microbe
Cell Host and Microbe, Elsevier, 2017, 21 (3), pp.376-389. ⟨10.1016/j.chom.2017.02.013⟩
Cell host & microbe, vol 21, iss 3
Bugaytsova, J A, Björnham, O, Chernov, Y A, Gideonsson, P, Henriksson, S, Mendez, M, Sjöström, R, Mahdavi, J, Shevtsova, A, Ilver, D, Moonens, K, Quintana-Hayashi, M P, Moskalenko, R, Aisenbrey, C, Bylund, G, Schmidt, A, Åberg, A, Brännström, K, Königer, V, Vikström, S, Rakhimova, L, Hofer, A, Ögren, J, Liu, H, Goldman, M D, Whitmire, J M, Ådén, J, Younson, J, Kelly, C G, Gilman, R H, Chowdhury, A, Mukhopadhyay, A K, Nair, G B, Papadakos, K S, Martinez-Gonzalez, B, Sgouras, D N, Engstrand, L, Unemo, M, Danielsson, D, Suerbaum, S, Oscarson, S, Morozova-Roche, L A, Olofsson, A, Gröbner, G, Holgersson, J, Esberg, A, Strömberg, N, Landström, M, Eldridge, A M, Chromy, B A, Hansen, L M, Solnick, J V, Lindén, S K, Haas, R, Dubois, A, Merrell, D S, Schedin, S, Remaut, H, Arnqvist, A, Berg, D E & Borén, T 2017, ' Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence ', Cell Host & Microbe, vol. 21, no. 3, pp. 376-389 . https://doi.org/10.1016/j.chom.2017.02.013

The BabA adhesin mediates high-affinity binding of Helicobacter pylori to the ABO blood group antigen-glycosylated gastric mucosa. Here we show that BabA is acid responsive-binding is reduced at low pH and restored by acid neutralization. Acid respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a43b410aab75acc08a9fa79a43ec0bb
https://hal-riip.archives-ouvertes.fr/pasteur-02195957

Use of Real-Time, Label-Free Analysis in Revealing Low-Affinity Binding to Blood Group Antigens by Helicobacter pylori

Autor: Thomas Borén, D X Johansson, Göran O. Bylund, Alexej Schmidt, Carlito B. Lebrilla, X D Zhu, Jay V. Solnick, Sara Henriksson, Y. Y. Fei

Publikováno v: Analytical Chemistry. 83:6336-6341

Infectious diseases are often initiated by microbial adherence that is mediated by the binding of attachment molecules, termed adhesins, to cell surface receptors on host cells. We present an experimental system, oblique-incidence reflectivity differ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b6f23f6d5a1faf9cfcdedaafb29dc15
https://doi.org/10.1021/ac201260c

Mechanism of suppression of chromosomal instability by DNA polymerase POLQ

Autor: Sylvie Doublié, David W. Wyatt, Sean C. Hensley, Richard D. Wood, Kevin M. McBride, Göran O. Bylund, Junya Tomida, Yunxiang Mu, Erik Johansson, Kei Ichi Takata, Matthew J. Yousefzadeh, Dale A. Ramsden

Publikováno v: PLoS Genetics
PLoS Genetics, Vol 10, Iss 10, p e1004654 (2014)

Although a defect in the DNA polymerase POLQ leads to ionizing radiation sensitivity in mammalian cells, the relevant enzymatic pathway has not been identified. Here we define the specific mechanism by which POLQ restricts harmful DNA instability. Ou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1bf2555b82a994f1999f0c480814d63
https://pubmed.ncbi.nlm.nih.gov/25275444