Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Göran Forsberg"'
Molecular Basis of Selective Cytokine Signaling Inhibition by Antibodies Targeting a Shared Receptor
Autor:
James K. Fields, Kyle Kihn, Gabriel S. Birkedal, Erik H. Klontz, Kjell Sjöström, Sebastian Günther, Robert Beadenkopf, Göran Forsberg, David Liberg, Greg A. Snyder, Daniel Deredge, Eric J. Sundberg
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Interleukin-1 (IL-1) family cytokines are potent mediators of inflammation, acting to coordinate local and systemic immune responses to a wide range of stimuli. Aberrant signaling by IL-1 family cytokine members, however, is linked to myriad inflamma
Externí odkaz:
https://doaj.org/article/d1aa83cba4b9429da818f4c99e7a5c77
Autor:
Gunnar Hedlund, Helena Eriksson, Anette Sundstedt, Göran Forsberg, Bent K Jakobsen, Nicholas Pumphrey, Karin Rödström, Karin Lindkvist-Petersson, Per Björk
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e79082 (2013)
The T lymphocytes are the most important effector cells in immunotherapy of cancer. The conceptual objective for developing the tumor targeted superantigen (TTS) ABR-217620 (naptumomab estafenatox, 5T4Fab-SEA/E-120), now in phase 3 studies for advanc
Externí odkaz:
https://doaj.org/article/7714f2df1eeb429698d214d001f27ccb
Autor:
Camilla Rydberg Millrud, Adnan Deronic, Caitríona Grönberg, Elin Jaensson Gyllenbäck, Karin von Wachenfeldt, Göran Forsberg, David Liberg
Publikováno v:
Cancer immunology, immunotherapy : CII.
IL-1α and IL-1β are both involved in several aspects of tumor biology, including tumor initiation, progression, metastasis, and not least in resistance to various therapies. IL-1α can function as an alarmin to signal cellular stress, and acts to i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95515910a2c5158d9e71a9dbc4a77eef
https://pubmed.ncbi.nlm.nih.gov/36036818
https://pubmed.ncbi.nlm.nih.gov/36036818
Publikováno v:
Science of The Total Environment. 651:2218-2227
The present study evaluated the toxicity of metal contamination in soils from an art glass factory in Smaland Sweden using a Caenorhabditis elegans nematode model. The aim of the study was to chemically analyze the soil samples and study the biologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3960bce46600b8e8cc2356888c30d65
https://doi.org/10.1016/j.scitotenv.2018.10.067
https://doi.org/10.1016/j.scitotenv.2018.10.067
Autor:
Hanna Håkansson Falk, Karin von Wachenfeldt, Göran Forsberg, David Liberg, Camilla Rydberg Millrud
Publikováno v:
Cancer Research. 80:2269-2269
Interleukin-1 (IL1) receptor accessory protein (IL1RAP) is a co-receptor of the IL1 receptor (IL1R1) and is required for IL1 signaling. IL1RAP is overexpressed in various solid tumors, both on cancer cells and in the tumor microenvironment. CAN04 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa5a8c3e71c7e7d7eefc8db956d456d8
https://doi.org/10.1158/1538-7445.am2020-2269
https://doi.org/10.1158/1538-7445.am2020-2269
Autor:
Michael J. Morris, Jan-Erik Damber, Lars Edenbrandt, Göran Forsberg, Roberto Pili, Andrew J. Armstrong, Reza Kaboteh, Orjan Nordle, Michael A. Carducci, Mats Hansen, Walter M. Stadler
Publikováno v:
Urologic Oncology: Seminars and Original Investigations. 32:1308-1316
Drug development and clinical decision making for patients with metastatic prostate cancer (PC) have been hindered by a lack of quantitative methods of assessing changes in bony disease burden that are associated with overall survival (OS). Bone scan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10ef84b29b7be0a23423532f9b35b47c
https://doi.org/10.1016/j.urolonc.2014.08.006
https://doi.org/10.1016/j.urolonc.2014.08.006
Publikováno v:
Journal of Bridge Engineering. 16:188-196
Stress-laminated timber bridge decks consist of several sawn timber beams or glue-laminated (glulam) beams held together with prestressed steel bars. Frictional shear stresses between the beams transfer loads between individual beams. Because the ver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa68e2016ff2ea76aae90f6f74ff3580
https://doi.org/10.1061/(asce)be.1943-5592.0000153
https://doi.org/10.1061/(asce)be.1943-5592.0000153
Autor:
Göran Forsberg, Matteo Riva, Karin von Wachenfeldt, David Liberg, Liselotte Larsson, Per-Ola Önnervik
Publikováno v:
Cancer Research. 78:1769-1769
Blockade of tumor inflammation has potential for cancer therapy, both as a primary mechanism to counter tumor growth but also in combination with other therapeutics. IL-1 signaling has been shown preclinically to be involved in tumor development and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12b8f3735ac9e00b5c1d41ffdeec2a83
https://doi.org/10.1158/1538-7445.am2018-1769
https://doi.org/10.1158/1538-7445.am2018-1769
Autor:
Göran Forsberg, Kristina Behm, Niels-Jörgen Skartved, Gunnar Hedlund, Marie Wallen-Ohman, Thore Nederman, Helen Carlsson Nyhlén
Publikováno v:
Journal of Immunotherapy. 33:492-499
Antibody-targeted superantigens have a potential to become useful drugs for tumor therapy. However, clinical practice has identified several issues that need to be addressed to optimize such molecules. On the basis of the experience from superantigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e116c06c45100c0e2e74eb4059427c
https://doi.org/10.1097/cji.0b013e3181d75820
https://doi.org/10.1097/cji.0b013e3181d75820
Autor:
Corey J. Langer, Andre Rogatko, Hossein Borghaei, Katherine Alpaugh, Ulrik Lassen, Roger B. Cohen, Svein Dueland, Gunnar Hedlund, Göran Forsberg, Robert E. Hawkins
Publikováno v:
Journal of Clinical Oncology. 27:4116-4123
PurposeTwo phase I studies were conducted of ABR-217620 alone or in combination with docetaxel. This is a recombinant fusion protein consisting of a mutated variant of the superantigen staphylococcal enterotoxin E (SEA/E-120) linked to fragment antig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c84ce09e28397c51ca719c6a3937e76
https://doi.org/10.1200/jco.2008.20.2515
https://doi.org/10.1200/jco.2008.20.2515