Zobrazeno 1 - 10
of 503
pro vyhledávání: '"Göran, Karlsson"'
Autor:
Johan Wallerstein, Xiao Han, Maria Levkovets, Dmitry Lesovoy, Daniel Malmodin, Claudio Mirabello, Björn Wallner, Renhua Sun, Tatyana Sandalova, Peter Agback, Göran Karlsson, Adnane Achour, Tatiana Agback, Vladislav Orekhov
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-18 (2024)
Abstract Mucosa-associated lymphoid tissue lymphoma-translocation protein 1 (MALT1) is an attractive target for the development of modulatory compounds in the treatment of lymphoma and other cancers. While the three-dimensional structure of MALT1 has
Externí odkaz:
https://doaj.org/article/884d29c1ed8241afb428cd2113dd173d
Autor:
Rebecca Warfvinge, Linda Geironson Ulfsson, Parashar Dhapola, Fatemeh Safi, Mikael Sommarin, Shamit Soneji, Henrik Hjorth-Hansen, Satu Mustjoki, Johan Richter, Ram Krishna Thakur, Göran Karlsson
Publikováno v:
eLife, Vol 12 (2024)
The advent of tyrosine kinase inhibitors (TKIs) as treatment of chronic myeloid leukemia (CML) is a paradigm in molecularly targeted cancer therapy. Nonetheless, TKI-insensitive leukemia stem cells (LSCs) persist in most patients even after years of
Externí odkaz:
https://doaj.org/article/d2afc990e3264278aae9d3f9ec4607bc
Autor:
Christian V. Recktenwald, Göran Karlsson, Maria-Jose Garcia-Bonete, Gergely Katona, Maja Jensen, Richard Lymer, Malin Bäckström, Malin E.V. Johansson, Gunnar C. Hansson, Sergio Trillo-Muyo
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114207- (2024)
Summary: The MUC2 mucin protects the colonic epithelium by a two-layered mucus with an inner attached bacteria-free layer and an outer layer harboring commensal bacteria. CysD domains are 100 amino-acid-long sequences containing 10 cysteines that sep
Externí odkaz:
https://doaj.org/article/9cf85ba6d78a4dee8ce486d5c3a77539
Autor:
Klas-Göran Karlsson
Publikováno v:
Nordisk Østforum, Vol 38 (2024)
Många sovjethistorier har skrivits, ofta utifrån en tämligen standardiserad innehållslig mall. Men varje decennium och varje generation skriver också sin egen sovjethistoria. En kort introduksjon til Sovjetunionen, ett uttryck för 2020-talets s
Externí odkaz:
https://doaj.org/article/63338cde47c74bf7bb7ad8baad66a90a
Concurrent stem- and lineage-affiliated chromatin programs precede hematopoietic lineage restriction
Autor:
Fatemeh Safi, Parashar Dhapola, Sarah Warsi, Mikael Sommarin, Eva Erlandsson, Jonas Ungerbäck, Rebecca Warfvinge, Ewa Sitnicka, David Bryder, Charlotta Böiers, Ram Krishna Thakur, Göran Karlsson
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113357- (2023)
Externí odkaz:
https://doaj.org/article/afa99b9a000946b79b1053681bd6ceed
Publikováno v:
Remote Sensing, Vol 15, Iss 23, p 5598 (2023)
The World Meteorological Organization (WMO) recommends that the most recent 30-year period, i.e., 1991–2020, be used to compute the climate normals of geophysical variables. A unique aspect of this recent 30-year period is that the satellite-based
Externí odkaz:
https://doaj.org/article/961a03aaf05046e58477d7d9601832a4
Autor:
Parashar Dhapola, Johan Rodhe, Rasmus Olofzon, Thomas Bonald, Eva Erlandsson, Shamit Soneji, Göran Karlsson
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
As the scale of single-cell genomics experiments grows into the millions, the computational requirements to process this data are beyond the reach of many. Here the authors present Scarf, a modularly designed Python package that makes the analysis wo
Externí odkaz:
https://doaj.org/article/60f7efb619a7412992aebe738a7a79f6
Autor:
Anna Konturek-Ciesla, Parashar Dhapola, Qinyu Zhang, Petter Säwén, Haixia Wan, Göran Karlsson, David Bryder
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112304- (2023)
Summary: Aging negatively affects hematopoiesis, with consequences for immunity and acquired blood cell disorders. Although impairments in hematopoietic stem cell (HSC) function contribute to this, the in vivo dynamics of such changes remain obscure.
Externí odkaz:
https://doaj.org/article/16e2103f62f84a6d9818638bcd2db14c
Publikováno v:
eLife, Vol 12 (2023)
Hematopoiesis is regulated by the bone marrow (BM) stroma. However, cellular identities and functions of the different BM stromal elements in humans remain poorly defined. Based on single-cell RNA sequencing (scRNAseq), we systematically characterize
Externí odkaz:
https://doaj.org/article/06b1fdfa9b2c4dd094f80e2739033bca
In vitro clonal multilineage differentiation of distinct murine hematopoietic progenitor populations
Autor:
Fatemeh Safi, Parashar Dhapola, Eva Erlandsson, Linda Geironson Ulfsson, Ariana S. Calderón, Charlotta Böiers, Göran Karlsson
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101965- (2023)
Summary: Here we describe an in vitro co-culture system that can differentiate hematopoietic progenitor populations to all major hematopoietic lineages at clonal level. We present both a sensitive single-cell switch-culture system as well as a less l
Externí odkaz:
https://doaj.org/article/5c57f55d5800494682503c01d97127a2