Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Gökçe Senger"'
Publikováno v:
eLife, Vol 11 (2022)
Aneuploidy, a state of chromosome imbalance, is a hallmark of human tumors, but its role in cancer still remains to be fully elucidated. To understand the consequences of whole-chromosome-level aneuploidies on the proteome, we integrated aneuploidy,
Externí odkaz:
https://doaj.org/article/f458247280e6471d95eb928989243348
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Huntington’s disease (HD) is a chronic neurodegenerative disorder caused by an expansion of polyglutamine repeats in exon 1 of the Huntingtin gene. Transcriptional dysregulation accompanied by epigenetic alterations is an early and central disease
Externí odkaz:
https://doaj.org/article/fa66b059ff204c45947fd7f64afccce6
Autor:
Gökçe Senger, Martin H. Schaefer
Publikováno v:
Frontiers in Bioinformatics, Vol 1 (2021)
Protein assembly is a highly dynamic process and proteins can interact in different ways and stoichiometries within a complex. The importance of maintaining protein stoichiometry for complex function and avoiding aggregation of orphan subunits has be
Externí odkaz:
https://doaj.org/article/64f9b12a3dff4b03a48c2613af10f733
Autor:
Hannah Benisty, Xavier Hernandez-Alias, Marc Weber, Miquel Anglada-Girotto, Federica Mantica, Leandro Radusky, Gökçe Senger, Ferriol Calvet, Donate Weghorn, Manuel Irimia, Martin H. Schaefer, Luis Serrano
Publikováno v:
Cell Systems. 14:312-323.e3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bcfacef2d729969ed8af716b4dff2002
https://doi.org/10.1016/j.cels.2023.02.002
https://doi.org/10.1016/j.cels.2023.02.002
Autor:
Hannah Benisty, Xavier Hernandez-Alias, Marc Weber, Miquel Anglada-Girotto, Federica Mantica, Leandro Radusky, Gökçe Senger, Donate Weghorn, Manuel Irimia, Martin H. Schaefer, Luis Serrano
BackgroundIn a wide variety of organisms, synonymous codons are used with different frequencies, a phenomenon known as codon bias that plays an important role in determining expression levels. However, the importance of codon bias to facilitate the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ca7f86fc532e77ad2efe9b2f305246e
https://doi.org/10.1101/2022.01.17.475622
https://doi.org/10.1101/2022.01.17.475622
Autor:
Gökçe Senger, Ferah Yildirim, Foteini Paraskevopoulou, Poorya Parvizi, Nurcan Tuncbag, Christian Rosenmund
Publikováno v:
Proc Natl Acad Sci U S A
Transcriptional dysregulation in Huntington’s disease (HD) causes functional deficits in striatal neurons. Here, we performed Patch-sequencing (Patch-seq) in an in vitro HD model to investigate the effects of mutant Huntingtin (Htt) on synaptic tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0659d85ad0794e5c4c3021154ae2c7a3
https://doi.org/10.1073/pnas.2020293118
https://doi.org/10.1073/pnas.2020293118