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Quantification of neutralizing anti-drug antibodies and their neutralizing capacity using competitive displacement and tandem mass spectrometry: Infliximab as proof of principle.

Autor: El Amrani M; Department of Clinical Pharmacy, Division of Laboratory Medicine and Pharmacy, University Medical Center Utrecht, Utrecht University, the Netherlands., Göbel C; Department of Clinical Pharmacy, Division of Laboratory Medicine and Pharmacy, University Medical Center Utrecht, Utrecht University, the Netherlands., Egas AC; Department of Clinical Pharmacy, Division of Laboratory Medicine and Pharmacy, University Medical Center Utrecht, Utrecht University, the Netherlands., Nierkens S; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, the Netherlands., Hack CE; Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht University, the Netherlands., Huitema ADR; Department of Clinical Pharmacy, Division of Laboratory Medicine and Pharmacy, University Medical Center Utrecht, Utrecht University, the Netherlands.; Department of Pharmacy & Pharmacology, Netherlands Cancer Institute, Amsterdam, the Netherlands., van Maarseveen EM; Department of Clinical Pharmacy, Division of Laboratory Medicine and Pharmacy, University Medical Center Utrecht, Utrecht University, the Netherlands.

Publikováno v: Journal of translational autoimmunity [J Transl Autoimmun] 2019 May 28; Vol. 1, pp. 100004. Date of Electronic Publication: 2019 May 28 (Print Publication: 2019).