Výsledky vyhledávání - "Gómez-Yafal A"

Akademický článek

Human Sulfatase 2 inhibits in vivo tumor growth of MDA-MB-231 human breast cancer xenografts

Autor: Peterson Sarah M, Iskenderian Andrea, Cook Lynette, Romashko Alla, Tobin Kristen, Jones Michael, Norton Angela, Gómez-Yafal Alicia, Heartlein Michael W, Concino Michael F, Liaw Lucy, Martini Paolo GV

Publikováno v: BMC Cancer, Vol 10, Iss 1, p 427 (2010)

Abstract Background Extracellular human sulfatases modulate growth factor signaling by alteration of the heparin/heparan sulfate proteoglycan (HSPG) 6-O-sulfation state. HSPGs bind to numerous growth factor ligands including fibroblast growth factors

Externí odkaz: https://doaj.org/article/e6955f3168a140e0a95768edca7a471e

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Role of Genes That Modulate Host Immune Responses in the Immunogenicity and Pathogenicity of Vaccinia Virus

Autor: Kimberly A. Zinnack, Norman L. Letvin, Kristin Beaudry, Alicia Gómez Yafal, Petr O. Ilyinskii, Dennis Panicali, Kelledy Manson, Shawn S. Jackson, Valerie Philippon, Marcelo J. Kuroda, Linda Gritz, Michelle A. Lifton, Gail P. Mazzara

Publikováno v: Journal of Virology. 79:6554-6559

Poxvirus vaccine vectors, although capable of eliciting potent immune responses, pose serious health risks in immunosuppressed individuals. We therefore constructed five novel recombinant vaccinia virus vectors which contained overlapping deletions o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9541e2a5eb8a75ac73a4c801a230912
https://doi.org/10.1128/jvi.79.10.6554-6559.2005

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Gender Differences in Human Immunodeficiency Virus Type 1-Specific CD8 Responses in the Reproductive Tract and Colon following Nasal Peptide Priming and Modified Vaccinia Virus Ankara Boosting

Autor: Herman F. Staats, Alicia Gómez Yafal, Sushila K. Nordone, Norman L. Letvin, Barton F. Haynes, Hua-Xin Liao, Shawn S. Jackson, James W. Peacock, Linda Gritz, Gail P. Mazzara

Publikováno v: Journal of Virology. 78:13163-13172

Induction of mucosal anti-human immunodeficiency virus type 1 (HIV-1) T-cell responses in males and females will be important for the development of a successful HIV-1 vaccine. An HIV-1 envelope peptide, DNA plasmid, and recombinant modified vaccinia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3faf01283d9b6bed2a4ddf75b698004e
https://doi.org/10.1128/jvi.78.23.13163-13172.2004

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A recombinant vector expressing transgenes for four T-cell costimulatory molecules (OX40L, B7-1, ICAM-1, LFA-3) induces sustained CD4+ and CD8+ T-cell activation, protection from apoptosis, and enhanced cytokine production

Autor: Alicia Gómez Yafal, Linda Gritz, Jeffrey Schlom, James W. Hodge, Douglas W. Grosenbach

Publikováno v: Cellular Immunology. 222:45-57

The role of OX40L on the activation of T cells was investigated using poxvirus vectors expressing OX40L alone or in combination with three other T-cell costimulatory molecules: B7-1, ICAM-1, and LFA-3. Poxvirus vector-infected cells were used to stim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e6e8d6de8ee5ddb5bb5b5154b0fdcc2
https://doi.org/10.1016/s0008-8749(03)00080-7

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From academic solos to industrial symphonies

Autor: Emily Walsh, Alicia Gómez-Yafal, Gwen Acton

Publikováno v: Nature biotechnology. 30(7)

Academic researchers often need to stand out to advance, but the corporate world calls for team players. Moving from one world to the other can be a culture shock.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d143e3a115b85bc612a6d6ac4f82ca00
https://pubmed.ncbi.nlm.nih.gov/22781674

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Characterization of Poliovirus Conformational Alteration Mediated by Soluble Cell Receptors

Autor: A Gómez Yafal, Vincent R. Racaniello, G Kaplan, James M. Hogle

Publikováno v: Virology. 197:501-505

Soluble extracts of Spodoptera frugiperda cells expressing the poliovirus receptor (PVR) induce the native poliovirus (PV) to "A" particle conformational change (J. Virol. 64, 4697-4702). We describe the variables that regulate this passage and study

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e469e81f003bce013d6947c326762e
https://doi.org/10.1006/viro.1993.1621

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Human Sulfatase 2 inhibits in vivo tumor growth of MDA-MB-231 human breast cancer xenografts

Autor: Lynette C. Cook, Michael A. Jones, Angela W. Norton, Paolo Martini, Sarah M. Peterson, Michael W. Heartlein, Michael F. Concino, Andrea Iskenderian, Alla Romashko, Kristen Tobin, Alicia Gómez-Yafal, Lucy Liaw

Publikováno v: BMC Cancer
BMC Cancer, Vol 10, Iss 1, p 427 (2010)

Background Extracellular human sulfatases modulate growth factor signaling by alteration of the heparin/heparan sulfate proteoglycan (HSPG) 6-O-sulfation state. HSPGs bind to numerous growth factor ligands including fibroblast growth factors (FGF), e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7c34c7e30eb2f83ef223a9a21f65e6
https://doi.org/10.1186/1471-2407-10-427

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Potential approach to immunotherapy of chronic lymphocytic leukemia (CLL): enhanced immunogenicity of CLL cells via infection with vectors encoding for multiple costimulatory molecules

Autor: Jarasvech Chinsangaram, Claudia Palena, Dennis L. Panicali, James W. Hodge, Kenneth A. Foon, Jeffrey Schlom, Kwong Y. Tsang, Alicia Gómez Yafal

Chronic lymphocytic leukemia (CLL) is a disease of CD5+ B lymphocytes (designated as CLL cells) that are inefficient antigen-presenting cells. Their poor ability to present antigens to the T cells, largely due to an inadequate costimulatory capacity,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628938c64496828a90b2e498db05feae
https://europepmc.org/articles/PMC1895050/

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Analyses of recombinant vaccinia and fowlpox vaccine vectors expressing transgenes for two human tumor antigens and three human costimulatory molecules

Autor: Kwong Y. Tsang, Linda Gritz, Dennis Panicali, Gail P. Mazzara, Claudia Palena, Alicia Gómez Yafal, James L. Gulley, Kelledy Manson, Sandra Ogueta, Jeffrey Schlom, Patricia Greenhalgh, Philip M. Arlen, Junko Yokokawa

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 11(4)

Purpose: The poor immunogenicity of tumor antigens and the antigenic heterogeneity of tumors call for vaccine strategies to enhance T-cell responses to multiple antigens. Two antigens expressed noncoordinately on most human carcinomas are carcinoembr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a3ad63e987f36b11fe04017a27923e8
https://pubmed.ncbi.nlm.nih.gov/15746065

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Modified vaccinia virus ankara recombinants are as potent as vaccinia recombinants in diversified prime and boost vaccine regimens to elicit therapeutic antitumor responses

Autor: James W, Hodge, Diane J, Poole, Wilhelmina M, Aarts, Alicia, Gómez Yafal, Linda, Gritz, Jeffrey, Schlom

Publikováno v: Cancer research. 63(22)

Cancer vaccine regimens use various strategies to enhance immune responses to specific tumor-associated antigens (TAAs), including the increasing use of recombinant poxviruses [vaccinia (rV) and fowlpox (rF)] for delivery of the TAA to the immune sys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b35333e44cac80c2de70bfea44836c08
https://pubmed.ncbi.nlm.nih.gov/14633725

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