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Peptide mimics of the thrombospondin C-terminal binding domain : analysis of their therapeutic potential to trigger immunogenic death of cancer cells targeting the TSP1–CD47 axis

Autor: Gómez-Morales, Luis

Publikováno v: Medicinal Chemistry. Sorbonne Université; Universidad autónoma de Nuevo León, 2021. English. ⟨NNT : 2021SORUS150⟩

Our team developed PKHB1, a peptide mimic of TSP1 able to induce caspase independent and Ca2+ dependent cell death in chronic lymphocytic leukemia (CLL), involving the activity of PLCG1, which overexpression correlates with CLL progression. In the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______1398::a3ef347e9faa8f356ca1912fe6436068
https://theses.hal.science/tel-03482025

Cenários para a submissão de excluídos de Justiça e Paz à Jurisdição Especial para a Paz: disquisição sobre seus âmbitos de aplicação

Autor: Rúa Delgado, Carlos Felipe, Duarte Molina, Tirson Mauricio, Gómez Morales, Luis Felipe

Publikováno v: Opinión Jurídica; Vol. 17 Núm. 35 (2018): Edición especial posconflicto; 117-146
Repositorio UDEM
Universidad de Medellín
instacron:Universidad de Medellín

The first transitional justice attempt in Colombia was the Ley the Justicia y Paz (Law of Justice andThe first transitional justice attempt in Colombia was the Ley the Justicia y Paz (Law of Justice and Peace Law, Law 975 of 2005), as a result of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::b7c5ab4177c0bb14114f2b9bce92f938

Supporting Information Homotrimerization Approach in the Design of Thrombospondin-1 Mimetic Peptides with Improved Potency in Triggering Regulated Cell Death of Cancer Cells

Autor: Denèfle, Thomas, Pramil, Elodie, Gómez-Morales, Luis, Levasseur, Mikail, Lardé, Eva, Newton, Clara, Herry, Kenny, Herbi, Linda, Lamotte, Yann, Odile, Estelle, Ancellin, Nicolas, Grondin, Pascal, Martinez-Torres, Ana-Carolina, Viviani, Fabrice, Merle-Béral, Hélène, Lequin, Olivier, Susin, Santos, Karoyan, Philippe

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2019, 62 (17), pp.7656-7668. ⟨10.1021/acs.jmedchem.9b00024⟩

International audience; In order to optimize the potency of the first serum-stable peptide agonist of CD47 (PKHB1) in triggering regulated cell death of cancer cells, we designed a maturation process aimed to mimic the trimeric structure of the throm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::377597376618d209fd42ff4d72a8f720
https://hal.sorbonne-universite.fr/hal-02367977/document

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