Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Géssica C. Barros"'
Autor:
Sezen Meydan, Géssica C. Barros, Vanessa Simões, Lana Harley, Blanche K. Cizubu, Nicholas R. Guydosh, Gustavo M. Silva
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113359- (2023)
Summary: Oxidative stress causes K63-linked ubiquitination of ribosomes by the E2 ubiquitin conjugase Rad6. How Rad6-mediated ubiquitination of ribosomes affects translation, however, is unclear. We therefore perform Ribo-seq and Disome-seq in Saccha
Externí odkaz:
https://doaj.org/article/60c50936146e4876a458eb95a3f76dfc
Autor:
Sezen Meydan, Géssica C. Barros, Vanessa Simões, Lana Harley, Blanche K. Cizubu, Nicholas R. Guydosh, Gustavo M. Silva
SUMMARYOxidative stress causes K63-linked ubiquitination of ribosomes by the E2 ubiquitin conjugase, Rad6. How Rad6-mediated ubiquitination of ribosomes affects global translation, however, is unclear. We therefore performed Ribo-seq and Disome-seq i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87c48565ccf870f707829c0bf72e1fcc
https://doi.org/10.1101/2022.09.27.509727
https://doi.org/10.1101/2022.09.27.509727
Publikováno v:
Biochemical Journal. 477:2921-2934
Protein segments with a high concentration of positively charged amino acid residues are often used in reporter constructs designed to activate ribosomal mRNA/protein decay pathways, such as those involving nonstop mRNA decay (NSD), no-go mRNA decay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8689488d284c1eded4e11e8805677d87
https://doi.org/10.1042/bcj20200303
https://doi.org/10.1042/bcj20200303
Autor:
Mariana H. Moreira, Géssica C. Barros, Fernando L. Palhano, Rodrigo D. Requião, Silvana Rossetto, Tatiana Domitrovic
Publikováno v:
RNA Biol
Translation initiation is a critical step in the regulation of protein synthesis, and it is subjected to different control mechanisms, such as 5’ UTR secondary structure and initiation codon context, that can influence the rates at which initiation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541251bd422ec7ee248aabc60665a592
https://doi.org/10.1080/15476286.2019.1661213
https://doi.org/10.1080/15476286.2019.1661213
Autor:
Rodrigo D. Requião, Fernando L. Palhano, Silvana Rossetto, Claudio A. Masuda, Géssica C. Barros, Rodolfo L. Carneiro, Tatiana Domitrovic, Mariana H. Moreira
Publikováno v:
Journal of Biological Chemistry. 296:100586
Highly positively charged protein segments are known to result in poor translation efficiency. This effect is explained by ribosome stalling caused by electrostatic interactions between the nascent peptide and the negatively charged ribosome exit tun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903338e7806de6949dd0a5d0ef084736
https://doi.org/10.1016/j.jbc.2021.100586
https://doi.org/10.1016/j.jbc.2021.100586