Zobrazeno 1 - 10
of 222
pro vyhledávání: '"Gérard Vergoten"'
Autor:
Gérard Vergoten, Christian Bailly
Publikováno v:
Future Journal of Pharmaceutical Sciences, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Background Telmisartan (TLT) is a prototypic angiotensin receptor blocker largely used to treat hypertension worldwide. In addition to its cardioprotective effects, TLT presents pleiotropic activities and notably displays noticeable anti-inf
Externí odkaz:
https://doaj.org/article/2ba3f4ddb2c842d18f0853f3ee34690e
Autor:
Gérard Vergoten, Christian Bailly
Publikováno v:
AppliedChem, Vol 3, Iss 2, Pp 217-228 (2023)
Among bryophytes, the Plagiochila genus represents a large group of leafy liverworts with over 500 species. Plagiochilins A to X are sesquiterpenoids isolated from Plagiochila species. The lead compound plagiochilin A (Plg-A), endowed with anticancer
Externí odkaz:
https://doaj.org/article/6c51b75d91294a688bb9e2ea498f0922
Autor:
Gérard Vergoten, Christian Bailly
Publikováno v:
Plants, Vol 13, Iss 9, p 1269 (2024)
The medicinal plant Securinega virosa (Roxb ex. Willd) Baill., also known as Flueggea virosa (Roxb. ex Willd.) Royle, is commonly used in traditional medicine in Africa and Asia for the management of diverse pathologies, such as parasite infections,
Externí odkaz:
https://doaj.org/article/4da7165f6c724adf87bf388c1abc520a
Publikováno v:
Biomedicine Hub, Vol 8, Iss 1, Pp 1-9 (2023)
Introduction: The quest for small molecule inhibitors of the PD-1/PD-L1 checkpoint continues in parallel to the extensive development of monoclonal antibodies directed against this immune checkpoint. Drug screening strategies are being set up to iden
Externí odkaz:
https://doaj.org/article/cfbce8c7f1474225b822349d97f97204
Autor:
Christian Bailly, Gérard Vergoten
Publikováno v:
Digital Chinese Medicine, Vol 5, Iss 1, Pp 9-17 (2022)
Objective: The mangrove tree Xylocarpus granatum J. Koenig (X. granatum) is a medicinal plant used to treat various diseases in several Asian countries. Many bioactive natural products have been isolated from the plants, particularly several groups o
Externí odkaz:
https://doaj.org/article/9c6b83bd8a854ec3a4d5b8533da277f0
Autor:
Christian Bailly, Gérard Vergoten
Publikováno v:
Molecules, Vol 28, Iss 4, p 1828 (2023)
The antitumor drug topotecan (TPT) is a potent inhibitor of topoisomerase I, triggering DNA breaks lethal for proliferating cancer cells. The mechanism is common to camptothecins SN38 (the active metabolite of irinotecan) and belotecan (BLT). Recentl
Externí odkaz:
https://doaj.org/article/7a4b278e22ff4fc9a621ae0e491de5f4
Autor:
Leila Mousavifar, Meysam Sarshar, Clarisse Bridot, Daniela Scribano, Cecilia Ambrosi, Anna Teresa Palamara, Gérard Vergoten, Benoît Roubinet, Ludovic Landemarre, Julie Bouckaert, René Roy
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 527 (2023)
Selective antiadhesion antagonists of Uropathogenic Escherichia coli (UPEC) type-1 Fimbrial adhesin (FimH) are attractive alternatives for antibiotic therapies and prophylaxes against acute or recurrent urinary tract infections (UTIs) caused by UPECs
Externí odkaz:
https://doaj.org/article/6aea907d3db0457581b05bbebb2f3810
Autor:
Gérard Vergoten, Christian Bailly
Publikováno v:
Plants, Vol 12, Iss 2, p 296 (2023)
Cryptoconcatones A-L represent a series of 12 dihydropyrone derivatives isolated from the evergreen tree Cryptocarya concinna Hance, which is well distributed in southeast Asia. The lead compound in the series, cryptoconcatone L, has revealed antipro
Externí odkaz:
https://doaj.org/article/d81928f072054912b25d0ad97e0a7dcb
Autor:
Gérard Vergoten, Christian Bailly
Publikováno v:
European Journal of Biological Research, Vol 11, Iss 4 (2021)
Drugs targeting the cell division cycle kinase 7 (Cdc7) are actively searched for the treatment of different pathologies such as amyotrophic lateral sclerosis and cancer. Cdc7 interacts with multiple protein partners, including protein Dbf4 to form t
Externí odkaz:
https://doaj.org/article/a6b8c17605cd486fbb6ded868152fd01
Autor:
Christian Bailly, Gérard Vergoten
Publikováno v:
Molecules, Vol 27, Iss 18, p 5909 (2022)
The para-terphenyl derivative vialinin A (Vi-A), isolated from Thelephora fungi, has been characterized as a potent inhibitor of the ubiquitin-specific protease 4 (USP4). Blockade of USP4 contributes to the anti-inflammatory and anticancer properties
Externí odkaz:
https://doaj.org/article/ad2f4bacc40d42c2a68d148582c52b05