Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Gérard Spach"'
Publikováno v:
International Journal of Peptide and Protein Research. 33:379-385
A 31-residue peptide, retro gramicidin A-dAla-gramicidin A, mimicking a gramicidin A dimer was prepared by solid phase method using a 4-(oxymethyl)-Pam resin and BOC as α amino protecting group. To avoid any possible formation of gramicidin A, coupl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63fedcee30c6bfebda333185ecc657cc
https://doi.org/10.1111/j.1399-3011.1989.tb00698.x
https://doi.org/10.1111/j.1399-3011.1989.tb00698.x
Polycondensation, D'Acides α-Aminés à L'Aide D'Un Couple Oxydant-Reducteur (Hg++ OU I2 - Phosphites)
Autor:
Lionel Le Guilly, Gérard Spach
Publikováno v:
Journal of Polymer Science: Polymer Symposia. 52:119-124
On a montre que l'action d'un couple d'agents, l'un oxydant (Hg++ ou I2) et l'autre reducteur (phosphite de diethyle) sur des acides α-amines libres en milieu pyridine conduit a la formation de polypeptides. La signification prebiotique d'un tel sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10abfe7fd5d8d32235469aa36f56ab94
https://doi.org/10.1002/polc.5070520113
https://doi.org/10.1002/polc.5070520113
Publikováno v:
Biophysical Journal. 63:868-873
In the "barrel-stave" model for voltage-gated alamethicin channels in planar lipid bilayers, proline residues, especially Pro14, are assumed to play a significant role. Taking advantage of a previous synthetic alamethicin analogue in which all eight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1195c26559c95eda93dc69ed5c8697c
https://doi.org/10.1016/s0006-3495(92)81637-5
https://doi.org/10.1016/s0006-3495(92)81637-5
Publikováno v:
Die Makromolekulare Chemie. 193:2379-2390
Fractionation of the products obtained by the Michelson polyaddition of glycerol 2-phosphate with diphenyl phosphate chloride gives a definite poly(glycerol phosphate) (PGP) of a molecular weight of about 1000. The exact structure was determined by 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::688e408dd29a91f8ceef45d637256a18
https://doi.org/10.1002/macp.1992.021930921
https://doi.org/10.1002/macp.1992.021930921
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1064:365-369
In a previous study, a synthetic analogue of the peptaibol alamethicin, in the sequence of which all alpha-aminoisobutyric acid (Aib) were substituted by leucine residues and the C-terminal residue modified, was shown to display the same single-chann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17559e22ccb101e9b2e67983c6fe4da6
https://doi.org/10.1016/0005-2736(91)90324-2
https://doi.org/10.1016/0005-2736(91)90324-2
Publikováno v:
Biophysical journal. 70(4)
Rings of inter-helix H-bonds due to Gln at position 7, a highly conserved residue in all pore-forming peptaibols, have been suggested to play an important role in the stabilization of alamethicin channels. In an attempt to test this hypothesis, exper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b3ed80a56e9d334f64f203eb07cd72
https://pubmed.ncbi.nlm.nih.gov/8785325
https://pubmed.ncbi.nlm.nih.gov/8785325
Some biochemical properties of an acyclic oligonucleotide analogue. A plausible ancestor of the DNA?
Publikováno v:
Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life. 23(2)
As acyclic oligonucleotides have been suggested as a primitive model of DNA or RNA in prebiotic times, we compared some biochemical properties of these analogues to that of natural ones. Firstly, an acyclic analogue of deoxyribonucleoside triphosphat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47741420ee73ccf7ce8afa3fd79d757
https://pubmed.ncbi.nlm.nih.gov/8384707
https://pubmed.ncbi.nlm.nih.gov/8384707
Autor:
Gérard Spach, André Brack
Publikováno v:
Biosystems. 20:95-98
One of the main characteristics of terrestrial life is the role of optically active organic substances. Thus a search for chiral compounds and optical activity on an extraterrestrial body may give an indication of the presence of life, either fossili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6dc9760b0e6237be4b58d9b87edf078
https://doi.org/10.1016/0303-2647(87)90024-4
https://doi.org/10.1016/0303-2647(87)90024-4
Autor:
André Brack, Gérard Spach
Publikováno v:
Journal of the American Chemical Society. 103:6319-6323
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98af1093a5eaf507c795759999d1a16a
https://doi.org/10.1021/ja00411a009
https://doi.org/10.1021/ja00411a009
Autor:
Gérard Spach, Liliane Merle
Publikováno v:
Annales de Physique. 14:235-244
L'origine ancestrale de l'asymetrie des biopolymeres, acides nucleiques et proteines, de la cellule vivante suscite depuis la decouverte de l'activite optique des biomolecules une vive discussion et la recherche d'une explication rationnelle. Dans de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44d583d9f6d143514fd5d45ccd384421
https://doi.org/10.1051/anphys:01989001402023500
https://doi.org/10.1051/anphys:01989001402023500