Výsledky vyhledávání - "Gérard Raffard"

Akademický článek

A neuronal MCT2 knockdown in the rat somatosensory cortex reduces both the NMR lactate signal and the BOLD response during whisker stimulation.

Autor: Leslie Mazuel, Jordy Blanc, Cendrine Repond, Véronique Bouchaud, Gérard Raffard, Nicole Déglon, Gilles Bonvento, Luc Pellerin, Anne-Karine Bouzier-Sore

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0174990 (2017)

Although several in vitro and ex vivo evidence support the existence of lactate exchange between astrocytes and neurons, a direct demonstration in vivo is still lacking. In the present study, a lentiviral vector carrying a short hairpin RNA (shRNA) w

Externí odkaz: https://doaj.org/article/6e9206443d9040fc96e8fc6e092c1fea

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Lactate transporters in the rat barrel cortex sustain whisker-dependent BOLD fMRI signal and behavioral performance

Autor: Eduardo R. Zimmer, Imad Benkhaled, Philippe Massot, Charlotte Jollé, Hélène Roumes, Véronique Bouchaud, Nicole Déglon, Luc Pellerin, Anne-Karine Bouzier-Sore, Jordy Blanc, Marc Biran, Gérard Raffard, Carolina Piletti Chatain, Catherine Pythoud

Publikováno v: Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2021, 118 (47), pp.e2112466118. ⟨10.1073/pnas.2112466118⟩
Proceedings of the National Academy of Sciences of the United States of America, 2021, 118 (47), ⟨10.1073/pnas.2112466118⟩
Proceedings of the National Academy of Sciences of the United States of America, vol. 118, no. 47, pp. e2112466118

International audience; Lactate is an efficient neuronal energy source, even in presence of glucose. However, the importance of lactate shuttling between astrocytes and neurons for brain activation and function remains to be established. For this pur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e5102816871d75909ca2a77e66286b
https://pubmed.ncbi.nlm.nih.gov/34782470

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Experimental sepsis-associated encephalopathy is accompanied by altered cerebral blood perfusion and water diffusion and related to changes in cyclooxygenase-2 expression and glial cell morphology but not to blood-brain barrier breakdown

Autor: Renaud Nicolas, Bassem Hiba, Olivier Periot, Marion Griton, Jan Pieter Konsman, Ibtihel Dhaya, Gérard Raffard

Publikováno v: Brain, Behavior, and Immunity
Brain, Behavior, and Immunity, Elsevier, 2020, 83, pp.200-213. ⟨10.1016/j.bbi.2019.10.012⟩

Sepsis-associated encephalopathy (SAE) refers to brain dysfunction, including delirium, occurs during severe infection and is associated with development of post-traumatic stress disorder. SAE has been proposed to be related to reduced cerebral blood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e4abaadb543e358a7ccd9a937776ed
https://hal.archives-ouvertes.fr/hal-03033791

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Functional Magnetic Resonance Spectroscopy at 7 T in the Rat Barrel Cortex During Whisker Activation

Autor: Leslie Mazuel, Hélène Roumes, Anne-Karine Bouzier-Sore, Marc Biran, Jordy Blanc, Gérard Raffard, Philippe Massot

Publikováno v: Journal of visualized experiments : JoVE
Journal of visualized experiments : JoVE, JoVE, 2019, ⟨10.3791/58912⟩
Journal of visualized experiments : JoVE, 2019, 144, ⟨10.3791/58912⟩

Nuclear magnetic resonance (NMR) spectroscopy offers the opportunity to measure cerebral metabolite contents in vivo and noninvasively. Thanks to technological developments over the last decade and the increase in magnetic field strength, it is now p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe70a302673846137ff0ba8036f0a95
https://hal-cnrs.archives-ouvertes.fr/hal-02472355

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MR imaging, targeting and characterization of pulmonary fibrosis using intra-tracheal administration of gadolinium-based nanoparticles

Autor: Andrea Bianchi, Olivier Tillement, François Lux, Gérard Raffard, Yannick Crémillieux, Nawal Tassali, Stéphane Sanchez

Publikováno v: Contrast Media & Molecular Imaging. 11:396-404

Idiopathic pulmonary fibrosis is a devastating disease. Animal models are critical to develop new diagnostic approaches. We investigate here whether the application of an ultra-short echo time MRI sequence combined with the intra-tracheal administrat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1def3cce4850832999bd5c97795e2003
https://doi.org/10.1002/cmmi.1703

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Deciphering the microstructure of hippocampal subfields with in vivo DTI and NODDI: Applications to experimental multiple sclerosis

Autor: Hikaru Fukutomi, Stéphane H. R. Oliet, Thomas Tourdias, Vincent Dousset, Aude Panatier, Nadège Dubourdieu, Julien Bourel, Vincent Planche, Gérard Raffard, Bassem Hiba, Amandine Crombé

Publikováno v: NeuroImage
NeuroImage, Elsevier, 2018, 172, pp.357-368. ⟨10.1016/j.neuroimage.2018.01.061⟩
NeuroImage, 2018, 172, pp.357-368. ⟨10.1016/j.neuroimage.2018.01.061⟩

The hippocampus contains distinct populations of neurons organized into separate anatomical subfields and layers with differential vulnerability to pathological mechanisms. The ability of in vivo neuroimaging to pinpoint regional vulnerability is esp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7952e91212295f378eec4cc35d4f6bd
https://hal-cnrs.archives-ouvertes.fr/hal-02404917

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Bacterial lipopolysaccharide-induced systemic inflammation alters perfusion of white matter-rich regions without altering flow in brain-irrigating arteries: Relationship to blood-brain barrier breakdown?

Autor: Marion Griton, Bassem Hiba, Mohamed Amri, Ibtihel Dhaya, Jan Pieter Konsman, Gérard Raffard

Publikováno v: Journal of Neuroimmunology
Journal of Neuroimmunology, Elsevier, 2018, 314, pp.67-80. ⟨10.1016/j.jneuroim.2017.11.009⟩

To better understand brain dysfunction during sepsis, cerebral arterial blood flow was assessed with Phase Contrast Magnetic Resonance Imaging, perfusion with Arterial Spin Labeling and structure with diffusion-weighted Magnetic Resonance Imaging in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c980f982f1cf78ba435dff885bb48bf0
https://pubmed.ncbi.nlm.nih.gov/29174195

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Selective dentate gyrus disruption causes memory impairment at the early stage of experimental multiple sclerosis

Autor: Eva-Gunnel Ducourneau, Aude Panatier, Marlène Maitre, Thierry Leste-Lasserre, Stéphane H. R. Oliet, Vincent Planche, Vincent Dousset, Thomas Tourdias, Gérard Raffard, Bruno Brochet, Bassem Hiba, Nadège Dubourdieu, Aline Desmedt

Publikováno v: Brain, Behavior, and Immunity
Brain, Behavior, and Immunity, Elsevier, 2017, 60, pp.240-254. ⟨10.1016/j.bbi.2016.11.010⟩

International audience; Memory impairment is an early and disabling manifestation of multiple sclerosis whose anatomical and biological substrates are still poorly understood. We thus investigated whether memory impairment encountered at the early st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6732eea63335acb02e3bdc5738c96f83
https://hal-cnrs.archives-ouvertes.fr/hal-02404774

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In vivoMRI for effective non-invasive detection and follow-up of an orthotopic mouse model of lung cancer

Autor: Andrea Bianchi, Jean-Luc Coll, Pierre-Yves Fortin, Olivier Tillement, Yannick Crémillieux, Nawal Tassali, François Lux, Gérard Raffard, Sandrine Dufort

Publikováno v: NMR in Biomedicine. 27:971-979

One of the main reasons for the dismal prognosis of lung cancer is related to the late diagnosis of this pathology. In this study, we evaluated the potential of optimized lung MRI techniques as a completely non-invasive approach for non-small-cell lu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99f4b0e1e99bfb9bb638aa0327bf9b2e
https://doi.org/10.1002/nbm.3142

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High-fructose diet enhances cerebral neurodegenerative process; preventive effect of resveratrol. A nuclear magnetic resonance imaging and spectroscopy study on rat nutritional models

Autor: Marie-Christine Beauvieux, Claire Chambre, Alan Stephant, Henri Gin, Anne-Karine Bouzier-Sore, Bader Chaarani, Gérard Raffard, Emmanuel Richard, Claire Castain, Patrice Couzigou, Jean-Louis Gallis

Publikováno v: Nutrition and Aging. 2:15-34

Insulin resistance (IR) could play a role in neurodegenerative diseases (ND). The high-fructose (HF) diet is an IR model in rats. The vitamin A-deprived (VAD) rat is known to develop large similarities with ND within only 14 weeks post-weaning. Since

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a32c5c5101bc40566b58a8228d2159c
https://doi.org/10.3233/nua-130031

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