Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Gérard Péhau-Arnaude"'
Autor:
Juliana Rizzo, Adèle Trottier, Frédérique Moyrand, Jean-Yves Coppée, Corinne Maufrais, Ana Claudia G. Zimbres, Thi Tuong Vi Dang, Alexandre Alanio, Marie Desnos-Ollivier, Isabelle Mouyna, Gérard Péhau-Arnaude, Pierre-Henri Commere, Sophie Novault, Iuliana V. Ene, Leonardo Nimrichter, Marcio L. Rodrigues, Guilhem Janbon
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Resistance to fluconazole (FLC), the most widely used antifungal drug, is typically achieved by altering the azole drug target and/or drug efflux pumps. Recent reports have suggested a link between vesicular trafficking and antifungal resist
Externí odkaz:
https://doaj.org/article/1274a0989de04827bef057b1db4905e4
Autor:
Marie S. Prevost, Nathalie Barilone, Gabrielle Dejean de la Bâtie, Stéphanie Pons, Gabriel Ayme, Patrick England, Marc Gielen, François Bontems, Gérard Pehau-Arnaudet, Uwe Maskos, Pierre Lafaye, Pierre-Jean Corringer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The human α7 nicotinic receptor is a pentameric channel mediating cellular and neuronal communication. It has attracted considerable interest in designing ligands for the treatment of neurological and psychiatric disorders. To develop a nov
Externí odkaz:
https://doaj.org/article/d6e9fbacc04e466aa0ecb78f49b2c30d
Autor:
Thierry Mourer, Mennat El Ghalid, Gérard Pehau-Arnaudet, Brice Kauffmann, Antoine Loquet, Sébastien Brûlé, Vitor Cabral, Christophe d’Enfert, Sophie Bachellier-Bassi
Publikováno v:
npj Biofilms and Microbiomes, Vol 9, Iss 1, Pp 1-16 (2023)
Abstract The human commensal fungus Candida albicans can attach to epithelia or indwelling medical devices and form biofilms, that are highly tolerant to antifungal drugs and can evade the immune response. The cell surface protein Pga59 has been show
Externí odkaz:
https://doaj.org/article/8cd84241961946acb2fee85a8d833f53
Autor:
Guillaume Borrel, Khaled Fadhlaoui, Wajdi Ben Hania, Nadia Gaci, Gérard Pehau-Arnaudet, Prem Prashant Chaudhary, Pascal Vandekerckove, Nathalie Ballet, Monique Alric, Paul William O’Toole, Marie-Laure Fardeau, Bernard Ollivier, Jean-François Brugère
Publikováno v:
Microorganisms, Vol 11, Iss 11, p 2794 (2023)
The methanogenic strain Mx-05T was isolated from the human fecal microbiome. A phylogenetic analysis based on the 16S rRNA gene and protein marker genes indicated that the strain is affiliated with the order Methanomassiliicoccales. It shares 86.9% 1
Externí odkaz:
https://doaj.org/article/ae3ea8acdd164189bdcfefe0d797dc3c
Autor:
Tobias Sahr, Pedro Escoll, Christophe Rusniok, Sheryl Bui, Gérard Pehau-Arnaudet, Gregory Lavieu, Carmen Buchrieser
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Legionella pneumophila expresses a range of bacterial determinants that mimic eukaryotic functions. Here the authors show small RNAs of L.pneumophila mimic eukaryotic microRNA and modulate the host response to infection.
Externí odkaz:
https://doaj.org/article/3df97bae629b4c4cb76dc65b011ff7e6
Autor:
Clément Madru, Ghislaine Henneke, Pierre Raia, Inès Hugonneau-Beaufet, Gérard Pehau-Arnaudet, Patrick England, Erik Lindahl, Marc Delarue, Marta Carroni, Ludovic Sauguet
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Replicative DNA polymerases (DNAPs) have evolved the ability to copy the genome with high processivity and fidelity. Here, the authors present a cryo-EM structure of the DNA-bound PolD–PCNA complex from Pyrococcus abyssi to reveal the molecular bas
Externí odkaz:
https://doaj.org/article/d0e3b6dc33ce4f07adff0554f5e474a0
Publikováno v:
Physical Review X, Vol 13, Iss 1, p 011014 (2023)
Networks of intermediate filaments (IFs) need to constantly reorganize to fulfil their functions at different locations within the cell. The mechanism of IF assembly is well described and involves filament end-to-end annealing. By contrast, the mecha
Externí odkaz:
https://doaj.org/article/88151ed6b349461890fe5a51d4f35579
Autor:
Juliana Rizzo, Sarah Sze Wah Wong, Anastasia D. Gazi, Frédérique Moyrand, Thibault Chaze, Pierre‐Henri Commere, Sophie Novault, Mariette Matondo, Gérard Péhau‐Arnaudet, Flavia C. G. Reis, Matthijn Vos, Lysangela R. Alves, Robin C. May, Leonardo Nimrichter, Marcio L. Rodrigues, Vishukumar Aimanianda, Guilhem Janbon
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 10, Pp n/a-n/a (2021)
Abstract Whereas extracellular vesicle (EV) research has become commonplace in different biomedical fields, this field of research is still in its infancy in mycology. Here we provide a robust set of data regarding the structural and compositional as
Externí odkaz:
https://doaj.org/article/df77d7ad98b34779831b82705fc651c8
Autor:
Pierre Raia, Marta Carroni, Etienne Henry, Gérard Pehau-Arnaudet, Sébastien Brûlé, Pierre Béguin, Ghislaine Henneke, Erik Lindahl, Marc Delarue, Ludovic Sauguet
Publikováno v:
PLoS Biology, Vol 17, Iss 1, p e3000122 (2019)
PolD is an archaeal replicative DNA polymerase (DNAP) made of a proofreading exonuclease subunit (DP1) and a larger polymerase catalytic subunit (DP2). Recently, we reported the individual crystal structures of the DP1 and DP2 catalytic cores, thereb
Externí odkaz:
https://doaj.org/article/ff23331df20647f8a096ed185fd83ce6
Autor:
Juliette Fedry, Jennifer Forcina, Pierre Legrand, Gérard Péhau-Arnaudet, Ahmed Haouz, Mark Johnson, Felix A Rey, Thomas Krey
Publikováno v:
PLoS Biology, Vol 16, Iss 8, p e2006357 (2018)
HAPLESS2 (HAP2) is a broadly conserved, gamete-expressed transmembrane protein that was shown recently to be structurally homologous to viral class II fusion proteins, which initiate fusion with host cells via insertion of fusion loops into the host
Externí odkaz:
https://doaj.org/article/47a8fd1cf8b94417b8dc24b331a3eec6