Pyrogenic synthetic amorphous silica (NM-203): Genotoxicity in rats following sub-chronic oral exposure

Autor: Paola Villani, Patrizia Eleuteri, Francesca Pacchierotti, Francesca Maranghi, Roberta Tassinari, Laura Narciso, Sabrina Tait, Gabriele Lori, Cristina Andreoli, Sylvie Huet, Gérard Jarry, Valérie Fessard, Eugenia Cordelli

Publikováno v: Mutation Research-Genetic Toxicology and Environmental Mutagenesis
Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 2022, 876-877, pp.503458. ⟨10.1016/j.mrgentox.2022.503458⟩

International audience; The genotoxicity of nano-structured synthetic amorphous silica (SAS), a common food additive, was investigated in vivo in rats. A 90-day oral toxicity study was performed according to OECD test guideline 408 and the genotoxici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37ae3714f5a4ed9c1b7f99b4d0487a5
https://doi.org/10.1016/j.mrgentox.2022.503458

Genotoxicity of synthetic amorphous silica nanoparticles in rats following short-term exposure. Part 1: Oral route

Autor: Maria João Silva, Gérard Jarry, Valérie Fessard, Ana Tavares, Nádia Vital, Martine Poul, Sylvie Huet, Rachelle Lanceleur, Henriqueta Louro, Adeline Tarantini

Publikováno v: Environmental and Molecular Mutagenesis. 56:218-227

Synthetic amorphous silica (SAS) in its nanosized form is now used in food applications although the potential risks for human health have not been evaluated. In this study, genotoxicity and oxidative DNA damage of two pyrogenic (NM-202 and 203) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72bad1627c30b7530a529bbb8a507c26
https://doi.org/10.1002/em.21935

In vivo DNA damage induced by the cyanotoxin microcystin-LR: Comparison of intra-peritoneal and oral administrations by use of the comet assay

Autor: Gérard Jarry, Julien Gaudin, Valérie Fessard, Sylvie Huet

Publikováno v: Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 652:65-71

Microcystin-LR (MC-LR), involved in human and animal poisonings by cyanobacteria, has been shown to be both a potent tumour promoter in rat liver and an inhibitor of serine/threonine protein phosphatases, specifically PP1 and PP2A. The research on th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a757eb125a46bf82a8e4ad292935bd5b
https://doi.org/10.1016/j.mrgentox.2007.10.024

Genotoxicity of synthetic amorphous silica nanoparticles in rats following short-term exposure. Part 1: oral route

Autor: Adeline, Tarantini, Sylvie, Huet, Gérard, Jarry, Rachelle, Lanceleur, Martine, Poul, Ana, Tavares, Nádia, Vital, Henriqueta, Louro, Maria, João Silva, Valérie, Fessard

Publikováno v: Environmental and molecular mutagenesis. 56(2)

Synthetic amorphous silica (SAS) in its nanosized form is now used in food applications although the potential risks for human health have not been evaluated. In this study, genotoxicity and oxidative DNA damage of two pyrogenic (NM-202 and 203) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c00654d19d50372534a2c0e88dd7acf2
https://pubmed.ncbi.nlm.nih.gov/25504566

Lack of genotoxic effect of food dyes amaranth, sunset yellow and tartrazine and their metabolites in the gut micronucleus assay in mice

Autor: Martine Poul, Mostafa Ould Elhkim, Jean-Michel Poul, Gérard Jarry

Publikováno v: Food and Chemical Toxicology
Food and Chemical Toxicology, Elsevier, 2009, 47 (2), pp.443-8. ⟨10.1016/j.fct.2008.11.034⟩

The food dyes amaranth, sunset yellow and tartrazine were administered twice, at 24h intervals, by oral gavage to mice and assessed in the in vivo gut micronucleus test for genotoxic effects (frequency of micronucleated cells) and toxicity (apoptotic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::765a2727fd88f1a49c0519d8628c55f1
https://hal-anses.archives-ouvertes.fr/hal-00405438