Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network

Autor: Valérie Schreiber, Reuben Mercier, Sara Jiménez, Tao Ye, Emmanuel García-Sánchez, Annabelle Klein, Aline Meunier, Sabitri Ghimire, Catherine Birck, Bernard Jost, Kristian Honnens de Lichtenberg, Christian Honoré, Palle Serup, Gérard Gradwohl

Publikováno v: Molecular Metabolism, Vol 53, Iss , Pp 101313- (2021)

Objective: Mice lacking the bHLH transcription factor (TF) Neurog3 do not form pancreatic islet cells, including insulin-secreting beta cells, the absence of which leads to diabetes. In humans, homozygous mutations of NEUROG3 manifest with neonatal o

Externí odkaz: https://doaj.org/article/0eee5b4bdcfb4b04ae1c515cc6791a74

Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production

Autor: Julie Piccand, Constance Vagne, Florence Blot, Aline Meunier, Anthony Beucher, Perrine Strasser, Mari L. Lund, Sabitri Ghimire, Laure Nivlet, Céline Lapp, Natalia Petersen, Maja S. Engelstoft, Christelle Thibault-Carpentier, Céline Keime, Sara Jimenez Correa, Valérie Schreiber, Nacho Molina, Thue W. Schwartz, Adèle De Arcangelis, Gérard Gradwohl

Publikováno v: Molecular Metabolism, Vol 29, Iss , Pp 24-39 (2019)

Objective: Enteroendocrine cells (EECs) of the gastro-intestinal tract sense gut luminal factors and release peptide hormones or serotonin (5-HT) to coordinate energy uptake and storage. Our goal is to decipher the gene regulatory networks controllin

Externí odkaz: https://doaj.org/article/ae5bc94129d345d5a7f7ab5313070cd2

Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity

Autor: Neal Anthwal, Michelle Pelling, Suzanne Claxton, Georg Mellitzer, Caitlin Collin, Nicoletta Kessaris, William D. Richardson, Gérard Gradwohl, Siew-Lan Ang

Publikováno v: Disease Models & Mechanisms, Vol 6, Iss 5, Pp 1133-1145 (2013)

SUMMARY The ventral hypothalamus acts to integrate visceral and systemic information to control energy balance. The basic helix-loop-helix transcription factor neurogenin-3 (Ngn3) is required for pancreatic β-cell development and has been implicated

Externí odkaz: https://doaj.org/article/5f550611b1a74183bc5fedc179c29251

Characterization of cell-fate decision landscapes by estimating transcription factor dynamics

Autor: Sara Jiménez, Valérie Schreiber, Reuben Mercier, Gérard Gradwohl, Nacho Molina

Modulation of gene expression during differentiation by transcription factors promotes cell diversity. Despite their role in cell fate decisions, no experimental assays estimate their regulatory activity in a high-throughput manner and at the single-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08bb7e9b966a3566237ae2e37c749290
https://doi.org/10.1101/2022.04.01.486696

Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells

Autor: Sarah Tonack, Thue W. Schwartz, Natalia Petersen, Céline Keime, Constance Vagne, Gérard Gradwohl, Jonathan James Thompson, Maja S. Engelstoft, Kristoffer L. Egerod, Stefan Offermanns, Kaare V. Grunddal

Publikováno v: V. Grunddal, K, Tonack, S, Egerod, K L, Thompson, J J, Petersen, N, Engelstoft, M S, Vagne, C, Keinse, C, Gradwohl, G, Offermanns, S & Schwartz, T W 2021, ' Adhesion receptor ADGRG2/GPR64 is in the GI-tract selectively expressed in mature intestinal tuft cells ', Molecular Metabolism, vol. 51, 101231 . https://doi.org/10.1016/j.molmet.2021.101231
Molecular metabolism
Molecular metabolism, 2021, 51, ⟨10.1016/j.molmet.2021.101231⟩
Molecular Metabolism, Vol 51, Iss, Pp 101231-(2021)

Objective: GPR64/ADGRG2 is an orphan Adhesion G protein-coupled receptor (ADGR) known to be mainly expressed in the parathyroid gland and epididymis. This investigation aimed to delineate the cellular expression of GPR64 throughout the body with focu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82dc901ce96c3307e57d9fc46b762068
https://doi.org/10.1016/j.molmet.2021.101231