Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Gérard Garnier"'
Publikováno v:
BMC Health Services Research, Vol 19, Iss 1, Pp 1-9 (2019)
Abstract Background Historically, governmental hospital organisation consisted in a heterogeneous distribution of staff and a fragmented logistical organisation without cross-functionality or sharing of resources between departments. This organisatio
Externí odkaz:
https://doaj.org/article/46f63a6a10e946a784c7eb0ddbd9b927
Publikováno v:
BMC Health Services Research
BMC Health Services Research, Vol 19, Iss 1, Pp 1-9 (2019)
BMC Health Services Research, Vol 19, Iss 1, Pp 1-9 (2019)
Background Historically, governmental hospital organisation consisted in a heterogeneous distribution of staff and a fragmented logistical organisation without cross-functionality or sharing of resources between departments. This organisation could n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95728300d654d86bfacb1104edefbc21
http://europepmc.org/articles/PMC6686463
http://europepmc.org/articles/PMC6686463
Publikováno v:
Biochemical Journal. 387:165-173
The availability of the human genome sequence allowed us to identify a human complement-related, C1r-like protease gene (c1r-LP) located 2 kb centromeric of the C1r gene (c1r). Compared with c1r, c1r-LP carries a large deletion corresponding to exons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7309efb3da7873c88d3e064feb6938
https://doi.org/10.1042/bj20041196
https://doi.org/10.1042/bj20041196
Publikováno v:
Molecular Immunology. 39:899-906
C1r and C1s are highly specific serine proteases that initiate the classical pathway of complement activation. We recently demonstrated that, in the mouse, the genes encoding these proteins are duplicated. Analysis of the 5'-flanking region of the mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::666c505475a940d2eb3b0e7e8aa2abcd
https://doi.org/10.1016/s0161-5890(02)00283-3
https://doi.org/10.1016/s0161-5890(02)00283-3
Autor:
Gérard Garnier, David E. Briles, Tünde Hidvégi, Harvey R. Colten, Antonella Circolo, Rick A. Wetsel, John E Volanakis, Xeufeng Wang, Alexander J. Szalai, Wataru Fukuda
Publikováno v:
Immunopharmacology. 42:135-149
Genetic deficiencies of the complement protein C3 occur naturally in humans and animal models and have been induced in mice by targeted deletion of the C3 gene. The study of these deficiencies has provided evidence for C3 functions in immune response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d22e1ec41e0c6bf6ebfdc0aa10829dc
https://doi.org/10.1016/s0162-3109(99)00021-1
https://doi.org/10.1016/s0162-3109(99)00021-1
Autor:
Lori Singer, Lawrence M. Nogee, Harvey R. Colten, Gérard Garnier, Harry C. Dietz, Anne M. Murphy, Daphne E. deMello
Publikováno v:
Journal of Clinical Investigation. 93:1860-1863
To determine the molecular defect accounting for the deficiency of pulmonary surfactant protein B (SP-B) in full-term neonates who died from respiratory failure associated with alveolar proteinosis, the sequence of the SP-B transcript in affected inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350d0a5e7b10d7b0f1a07e778db3e6f9
https://doi.org/10.1172/jci117173
https://doi.org/10.1172/jci117173
C1r and C1s are the serine proteases that form the catalytic unit of the C1 complex, the first component of complement. In the present study, we found that the genes encoding murine C1r and C1s are duplicated. One set of these genes, referred to as c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8e672c483bff3f177d3469f3e8bf5a
https://europepmc.org/articles/PMC1223281/
https://europepmc.org/articles/PMC1223281/
Autor:
Christine Gaboriaud, Gérard Garnier, Juan C. Fontecilla-Camps, Nicole M. Thielens, Monika Budayova-Spano, John E. Volanakis, Gérard J. Arlaud, Antonella Circolo
Publikováno v:
Immunobiology. 205(4-5)
C1r, the enzyme responsible for intrinsic activation of the C1 complex of complement, is a modular serine protease featuring an overall structural organization homologous to those of C1s and the mannan-binding lectin-associated serine proteases (MASP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0172eeafec2d8ed94c7d610001b8eaa
https://pubmed.ncbi.nlm.nih.gov/12396000
https://pubmed.ncbi.nlm.nih.gov/12396000
Autor:
V. Michael Holers, Gary S. Gilkeson, Philip Ruiz, Hideharu Sekine, Gérard Garnier, Antonella Circolo, Susan A. Boackle, Ivan Molano, Christopher M. Reilly
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 166(10)
Complement activation and tissue deposition of complement fragments occur during disease progression in lupus nephritis. Genetic deficiency of some complement components (e.g., Factor B) and infusion of complement inhibitors (e.g., Crry, anti-C5 Ab)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d809d9fc81c616d31027ea55ff4428
https://pubmed.ncbi.nlm.nih.gov/11342671
https://pubmed.ncbi.nlm.nih.gov/11342671
Autor:
Harvey R. Colten, Antonella Circolo, Hiroshi Watanabe, Gérard Garnier, V. Michael Holers, Gary S. Gilkeson, Susan A. Boackle, Phil Ruiz, Rick A. Wetsel
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 164(2)
In systemic lupus erythematosus, the renal deposition of complement-containing immune complexes initiates an inflammatory cascade resulting in glomerulonephritis. Activation of the classical complement pathway with deposition of C3 is pathogenic in l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa301f1352d0090e35d51f878e460103
https://pubmed.ncbi.nlm.nih.gov/10623824
https://pubmed.ncbi.nlm.nih.gov/10623824