Výsledky vyhledávání - "Gérard Dumas"

Biophysical stimuli induced by passive movements compensate for lack of skeletal muscle during embryonic skeletogenesis

Autor: Gérard Dumas, Shahragim Tajbakhsh, Paula Murphy, Niamh C. Nowlan, Patrick J. Prendergast

Publikováno v: Biomechanics and modeling in mechanobiology

In genetically modified mice with abnormal skeletal muscle development, bones and joints are differentially affected by the lack of skeletal muscle. We hypothesise that unequal levels of biophysical stimuli in the developing humerus and femur can exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed8f8cdd424d661217b30c86ef3c3c8a
https://doi.org/10.1007/s10237-011-0304-4

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Somatic mutations can lead to a loss of superantigenic and polyreactive binding

Autor: Otto Pritsch, Alfonso Cayota, Jean-Pierre Bouvet, Pablo Oppezzo, Carlos Robello, Gérard Dumas, Juan C. Pizarro, Guillaume Dighiero

Publikováno v: European Journal of Immunology. 34:1423-1432

Although antibodies have been assumed to bind a specific antigen, evidence exists showing that a single antibody can bind to multiple unrelated antigens. We previously studied a human monoclonal antibody expressing a mutated form of the V(H)3-73 gene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a68724ecae634be2a1a67e9acc9413d
https://doi.org/10.1002/eji.200424936

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Idiotype-pulsed dendritic cells are able to induce antitumoral cytotoxic CD8 cells in chronic lymphocytic leukaemia

Autor: Daniel Scott-Algara, Elaine K. Thomas, Françoise Vuillier, Karim Maloum, Gérard Dumas, Pablo Oppezzo, C. Magnac, Béatrice Payelle-Brogard, Gijillaume Dighiero

Publikováno v: British Journal of Haematology. 120:243-250

Summary. Idiotypic structures of immunoglobulins from malignant B cells constitute tumour-specific antigens, though the function of immunoglobulin-specific CD8+ T cells in disease control and rejection remains unclear. We have studied five cases of B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67058526b482b8b96dec19bfb8dda915
https://doi.org/10.1046/j.1365-2141.2003.04075.x

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Transgenic B lymphocytes expressing a human cold agglutinin escape tolerance following experimental infection of mice byMycoplasma pulmonis

Autor: Guillaume Dighiero, Christine Pourcel, Patrick Ave, Gérard Dumas, Michel Huerre, Isabelle Chambaud, Alain Blanchard, Séverine Havouis

Publikováno v: European Journal of Immunology. 32:1147-1156

‐cells, which expressed the transgenic immunoglobulin. Immunization of the transgenic mice with keyhole limpet hemocyanin and Freund’s adjuvant, to nonspecifically stimulate the expression of the passenger transgenes, only moderately increased th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4bf026f8b646f7592cb6eef40a1debe0
https://doi.org/10.1002/1521-4141(200204)32:4<1147::aid-immu1147>3.0.co

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VHgene usage by family members affected with chronic lymphocytic leukaemia

Autor: Francesca Romana Mauro, Frederic Davi, Franco Mandelli, Béatrice Payelle-Brogard, Otto Pritsch, Gérard Dumas, Guillaume Dighiero, C. Magnac, Marc Pulik, Françoise Clerget, Xavier Troussard, Nicholas Chiorazzi, Harry W. Schroeder, Michel Leporrier

Publikováno v: British Journal of Haematology. 107:616-624

Summary. The excess risk of chronic lymphocytic leukaemia (CLL) in the first-degree relatives of affected patients suggests that familial CLL might constitute a useful model to study the pathogenesis of this disease, as has been demonstrated in numer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c666282d3d6d2828fda3d307a2434594
https://doi.org/10.1046/j.1365-2141.1999.01757.x

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Embryonic founders of adult muscle stem cells are primed by the determination gene Mrf4

Autor: Clémire Cimper, Isabelle Roux, Julie Konge, Glenda Comai, Shahragim Tajbakhsh, Ramkumar Sambasivan, Danielle Gomès, Gérard Dumas

Publikováno v: Developmental Biology
Developmental Biology, Elsevier, 2013, 381 (1), pp.241-255. ⟨10.1016/j.ydbio.2013.04.018⟩
Developmental Biology, 2013, 381 (1), pp.241-255. ⟨10.1016/j.ydbio.2013.04.018⟩

Skeletal muscle satellite cells play a critical role during muscle growth, homoeostasis and regeneration. Selective induction of the muscle determination genes Myf5, Myod and Mrf4 during prenatal development can potentially impact on the reported fun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f23285f5f154a603fa5f62fc9c41e62
https://hal.archives-ouvertes.fr/hal-02367275

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V gene usage by seven hybrids derived from CD5+ B-cell chronic lymphocytic leukemia and displaying autoantibody activity

Autor: Otto Pritsch, Coumaran Egile, Gérard Dumas, C. Magnac, Guillaume Dighiero

Publikováno v: Blood. 82:3103-3112

We report here the complete heavy and light chain variable region sequences of seven heterohybridomas derived from CD5+ chronic lymphocytic leukemia (CLL) B lymphocytes and displaying natural autoantibody activity. The three hybrids displaying a poly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2374781d6e0bfc516adaa18c38e1b0bb
https://doi.org/10.1182/blood.v82.10.3103.3103

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Distinct Regulatory Cascades Govern Extraocular and Pharyngeal Arch Muscle Progenitor Cell Fates

Autor: Ramkumar, Sambasivan, Barbara, Gayraud-Morel, Gérard, Dumas, Clémire, Cimper, Sylvain, Paisant, Robert G, Kelly, Robert, Kelly, Shahragim, Tajbakhsh

Publikováno v: Developmental Cell
Developmental Cell, Elsevier, 2009, 16, pp.810-21
Developmental Cell, 2009, 16, pp.810-21
Developmental Cell; Vol 16

SummaryGenetic regulatory networks governing skeletal myogenesis in the body are well understood, yet their hierarchical relationships in the head remain unresolved. We show that either Myf5 or Mrf4 is necessary for initiating extraocular myogenesis.

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Abnormal levels of the alpha chain of the CD22 adhesion molecule may account for low CD22 surface expression in chronic lymphocytic leukemia

Autor: Guillermo Dighiero, Béatrice Payelle-Brogard, Françoise Vuillier, Ana Inés Lalanne, Gérard Dumas, C. Magnac

Publikováno v: Leukemia
Leukemia, Nature Publishing Group: Open Access Hybrid Model Option B, 2006, 20, pp.877-8. ⟨10.1038/sj.leu.2404155⟩
Leukemia, 2006, 20, pp.877-8. ⟨10.1038/sj.leu.2404155⟩

Abnormal levels of the α chain of the CD22 adhesion molecule may account for low CD22 surface expression in chronic lymphocytic leukemia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::018ae3fe674aec79a3b5beeaff4048e4
https://hal-pasteur.archives-ouvertes.fr/pasteur-00161575

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Lower levels of surface B-cell-receptor expression in chronic lymphocytic leukemia are associated with glycosylation and folding defects of the mu and CD79a chains

Autor: Béatrice Payelle-Brogard, Ana Inés Lalanne, Evie Melanitou, Pablo Oppezzo, Françoise Vuillier, Marie-Christine Prévost, Guillaume Dighiero, Gérard Dumas, C. Magnac

Publikováno v: Blood
Blood, 2005, 105 (7), pp.2933-40. ⟨10.1182/blood-2004-09-3643⟩
Blood, American Society of Hematology, 2005, 105 (7), pp.2933-40. ⟨10.1182/blood-2004-09-3643⟩

Low levels of B-cell-receptor (BCR) expression are the hallmark of tumoral B lymphocytes in B-cell chronic lymphocytic leukemia (B-CLL). These cells also respond inadequately to stimulation through the BCR. This receptor consists of a surface immunog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e368920a17952fa9e08ea5e343934c3b
https://hal-pasteur.archives-ouvertes.fr/pasteur-00177375

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