Grape Pomace: Antioxidant Activity, Potential Effect Against Hypertension and Metabolites Characterization after Intake

Autor: Zuriñe Rasines-Perea, Isabelle Ky, Gérard Cros, Alan Crozier, Pierre-Louis Teissedre

Publikováno v: Diseases, Vol 6, Iss 3, p 60 (2018)

Observational studies indicate that the intake of polyphenol-rich foods improves vascular health, thereby significantly reducing the risk of hypertension and cardiovascular disease (CVD). Therefore, the aim of this study was to analyse the remained p

Externí odkaz: https://doaj.org/article/5cf4fb52d1294baa9b61b7c63b6bb729

Liver‐Expressed Antimicrobial Peptide 2 antagonizes the insulinostatic effect of ghrelin in rat isolated pancreatic islets

Autor: Gérard Cros, Morgane Bayle, Jérémie Neasta, Catherine Oiry, Sylvie Peraldi-Roux, Guillaume Gautheron

Publikováno v: Fundamental and Clinical Pharmacology
Fundamental and Clinical Pharmacology, Wiley, 2021, ⟨10.1111/fcp.12722⟩
Fundamental and Clinical Pharmacology, Wiley, In press, ⟨10.1111/fcp.12722⟩

Background The hormone ghrelin is the endogenous agonist of the G-protein coupled receptor (GPCR) termed growth-hormone secretagogue receptor (GHSR). Ghrelin inhibits glucose-stimulated insulin secretion by activating pancreatic GHSR. Recently, Liver

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2760051bff0163caf16961e93f80a5e
https://hal.archives-ouvertes.fr/hal-03370769

Effets et mécanismes d’action d'analogues structuraux de la quercétine sur la sécrétion d'insuline induite par le glucose

Autor: Guillaume Gautheron, chabi beatrice, Sylvie Peraldi-Roux, Jean-François Quignard, Anne Virsolvy, Guyen, Julie N., Estelle Youl, Maxime Bayle, Gérard Cros, Jérémie Neasta, Catherine Oiry

Publikováno v: Congrès SFD 2020 (Société Francophone du Diabète)
Congrès SFD 2020 (Société Francophone du Diabète), Sep 2020, Bruxelles, Belgique. 1p., 2020
HAL
Congrès SFD 2020 (Société Francophone du Diabète), Sep 2020, Bruxelles, Belgique. 4p

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d687b2048af09f98d658837ff2e91fd7
https://hal.inrae.fr/hal-02941489

Urolithin C increases glucose-induced ERK activation which contributes to insulin secretion

Autor: Jérémie Neasta, Gérard Cros, Slimane Toubal, Morgane Bayle, Catherine Oiry

Publikováno v: Fundamentalclinical pharmacologyREFERENCES. 34(5)

Polyphenols exert pharmacological actions through protein-mediated mechanisms and by modulating intracellular signalling pathways. We recently showed that a gut-microbial metabolite of ellagic acid named urolithin C is a glucose-dependent activator o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a045ff48c249c5b15cd0c405de10adb
https://pubmed.ncbi.nlm.nih.gov/32083757

Development and validation of a liquid chromatography-electrospray ionization-tandem mass spectrometry method for the determination of urolithin C in rat plasma and its application to a pharmacokinetic study

Autor: Céline Roques, Gérard Cros, Michel Audran, Françoise M.M. Bressolle-Gomeni, Bénédicte Marion, Morgane Bayle, Catherine Oiry

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis. 131:33-39

Urolithins are microflora human metabolites of dietary ellagic acid derivatives. There is now a growing interest in the biological activities of these compounds. Several studies suggest that urolithins have potential antioxidant, anti-inflammatory, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5b7dcf0fbb16551883b594cc06b234
https://doi.org/10.1016/j.jpba.2016.07.046