Výsledky vyhledávání - "Gérard, Bolbach"

Akademický článek

Proteomic comparison of the EWS-FLI1 expressing cells EF with NIH-3T3 and actin remodeling effect of (R/W)9 cell-penetrating peptide

Autor: Séverine Clavier, Françoise Illien, Sandrine Sagan, Gérard Bolbach, Emmanuelle Sachon

Publikováno v: EuPA Open Proteomics, Vol 10, Iss C, Pp 1-8 (2016)

EWS-FLI1 expression in NIH-3T3 fibroblasts has a profound impact on the phenotype, resulting in the cytoskeleton and adhesive capacity disorganization (EF cells). Besides this, (R/W)9, a cell-penetrating peptide (CPP), has an intrinsic actin remodeli

Externí odkaz: https://doaj.org/article/d0a488ee0faf43619d55ac68f90fffdf

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Akademický článek

An integrated cross-linking-MS approach to investigate cell penetrating peptides interacting partners

Autor: Séverine Clavier, Xiuxia Du, Sandrine Sagan, Gérard Bolbach, Emmanuelle Sachon

Publikováno v: EuPA Open Proteomics, Vol 3, Iss C, Pp 229-238 (2014)

Cell penetrating peptides (CPPs) are attracting attention because of their ability to deliver biologically active molecules into cells. On their way they can interact with membrane and intracellular proteins. To fully understand and improve CPP effic

Externí odkaz: https://doaj.org/article/af7f0b5223ff4360b5c68414a3b63b3a

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A cationic motif in Engrailed-2 homeoprotein controls its internalization via selective cell-surface glycosaminoglycans interactions

Autor: Alain Joliot, Astrid Walrant, Françoise Illien, Sandrine Sagan, Olivier Lequin, Gérard Bolbach, Fabienne Burlina, Jean-Claude Jacquinet, Delphine Ravault, Laura Molina, Yadira P. Hervis, Bingwei He, Sébastien Cardon, Ludovic Carlier, Chrystel Lopin-Bon

Engrailed-2 (En2) is a transcription factor that possesses as most homeoproteins the unique and intriguing property to transfer from cell to cell through unconventional pathways. The internalization mechanism of this cationic protein is far from bein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52988369e5be299a35415f6ab50205d4
https://hal.archives-ouvertes.fr/hal-03429466

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Benzophenone Photoreactivity in a Lipid Bilayer To Probe Peptide/Membrane Interactions: Simple System, Complex Information

Autor: Gilles Clodic, Emmanuelle Sachon, Lucrèce Matheron, Carla Kirschbaum, Leïla Bechtella, Marine Cosset, Gérard Bolbach, Astrid Walrant, Sandrine Sagan

Publikováno v: Analytical Chemistry
Analytical Chemistry, American Chemical Society, 2019, 91 (14), pp.9102-9110. ⟨10.1021/acs.analchem.9b01584⟩

International audience; Affinity photo-cross-linking coupled to mass spec-trometry, using benzophenone (Bzp)-functionalized peptides, was used to study the noncovalent interactions of cell-penetrating peptides and lipid membranes. Using biomimetic li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3be76fd476e5dbdada8b89b35fd05202
https://doi.org/10.1021/acs.analchem.9b01584

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Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease

Publikováno v: European Journal of Preventive Cardiology
European Journal of Preventive Cardiology, Sage Publications, In press, pp.204748731989411. ⟨10.1177/2047487319894114⟩
European Journal of Preventive Cardiology, 2020, 27 (15), pp.1606-1616. ⟨10.1177/2047487319894114⟩
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Background: Low concentrations of high-density lipoprotein cholesterol (HDL-C) represent a well-established cardiovascular risk factor. Paradoxically, extremely high HDL-C levels are equally associated with elevated cardiovascular risk, resulting in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bb2443d1513d6e8186697ac8e2ca25
https://hal.sorbonne-universite.fr/hal-02433564/document

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Kinetic and structural characterization of therapeutic albumin chemical functionalization using complementary mass spectrometry techniques

Autor: Daniel Scherman, Yannis-Nicolas François, Gilles Clodic, Pascal Houzé, Rabah Gahoual, Nathalie Mignet, Gérard Bolbach, Ikram Ould-Melha

Publikováno v: Journal of Pharmaceutical and Biomedical Analysis
Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2020, 185, pp.113242. ⟨10.1016/j.jpba.2020.113242⟩

International audience; Protein conjugates such as antibody-drugs conjugates (ADCs) represents the next generation of therapeutic proteins. They allow to combine the biological properties of the protein format with the characteristics of the conjugat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0272ec9e4e578e48cbc3db5a88959884
https://hal.archives-ouvertes.fr/hal-03022806/document

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Search for biomarkers of neurosarcoidosis by proteomic analysis of cerebrospinal fluid

Autor: Bruno Baudin, Ludmia Taibi, Bénédicte Bénéteau-Burnat, Gérard Bolbach, Céline Boursier, Michel Vaubourdolle, Gilles Clodic

Publikováno v: Annales de biologie clinique. 75:393-402

Sarcoidosis is a systemic granulomatous disease, which mostly affects lung. Central nervous system can be affected causing a neurosarcoidosis in 5 to 15% of all sarcoidosis patients. The definitive diagnosis is established on histological examination

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886092cdeda55990df06f6003479dfb3
https://doi.org/10.1684/abc.2017.1260

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Exploiting Benzophenone Photoreactivity To Probe the Phospholipid Environment and Insertion Depth of the Cell-Penetrating Peptide Penetratin in Model Membranes

Autor: Sandrine Sagan, Isabel D. Alves, Chen-Yu Jiao, Gérard Chassaing, Emmanuelle Sachon, Gérard Bolbach

Publikováno v: Angewandte Chemie International Edition
Angewandte Chemie International Edition, Wiley-VCH Verlag, 2017, 56 (28), pp.8226-8230. ⟨10.1002/anie.201703465⟩
Angewandte Chemie International Edition, 2017, 56 (28), pp.8226-8230. ⟨10.1002/anie.201703465⟩

International audience; Penetratin (RQIKIWFQNRRMKWKK) enters cells by different mechanisms, including membrane translocation, thus implying that the peptide interacts with the lipid bilayer. Penetratin also crosses the membrane of artificial vesicles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63b6340f64a541a1e4d2ea1f80aae7c6
https://doi.org/10.1002/anie.201703465

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Input of serum haptoglobin fucosylation profile in the diagnosis of hepatocellular carcinoma in patients with non-cirrhotic liver disease

Autor: David M. Lubman, Valentina Peta, Keyvan Rezai, Gérard Bolbach, Samuel Huguet, Jianhui Zhu, Thierry Poynard, Francoise Imbert-Bismutd, Pais Raluca, Chantal Housset, Lucrèce Matheron, Yen Ngo, Gilles Clodic

Publikováno v: Clin Res Hepatol Gastroenterol
Clinics and Research in Hepatology and Gastroenterology
Clinics and Research in Hepatology and Gastroenterology, 2020, 44, pp.681-691. ⟨10.1016/j.clinre.2019.12.010⟩
Clinics and Research in Hepatology and Gastroenterology, Elsevier, 2020, 44, pp.681-691. ⟨10.1016/j.clinre.2019.12.010⟩

Summary Background Haptoglobin bifucosylated tetra-antennary glycan have been identified in patients with early stage hepatocellular carcinoma, but its specificity according to the presence or not of cirrhosis has never been assessed. The aims of thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f885677bed7a153a2304a662a98d6dbb
https://pubmed.ncbi.nlm.nih.gov/31964615

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