Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice

Autor: Eva Conde, Romain Bertrand, Bianca Balbino, Jonathan Bonnefoy, Julien Stackowicz, Noémie Caillot, Fabien Colaone, Samir Hamdi, Raïssa Houmadi, Alexia Loste, Jasper B. J. Kamphuis, François Huetz, Laurent Guilleminault, Nicolas Gaudenzio, Aurélie Mougel, David Hardy, John N. Snouwaert, Beverly H. Koller, Vincent Serra, Pierre Bruhns, Géraldine Grouard-Vogel, Laurent L. Reber

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Asthma is caused by hyperreactivity to benign antigens, with humoral immunity orchestrated by interleukin-4 (IL-4) and IL-13 being the key etiological factor. Here the authors show, in humanized mouse models, that dual vaccination against IL-4 and IL

Externí odkaz: https://doaj.org/article/aa43d94c3b9c4cd69ba35a1d0034149e

Therapeutic vaccination with TNF-Kinoid in TNF antagonist-resistant rheumatoid arthritis: a phase II randomized, controlled clinical trial.

Autor: Patrick Durez, Pierre Vandepapeliere, Pedro Miranda, Antoaneta Toncheva, Alberto Berman, Tatjana Kehler, Eugenia Mociran, Bruno Fautrel, Xavier Mariette, Olivier Dhellin, Bernard Fanget, Stephane Ouary, Géraldine Grouard-Vogel, Marie-Christophe Boissier

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e113465 (2014)

OBJECTIVES:Active immunization, or vaccination, with tumor necrosis factor (TNF)-Kinoid (TNF-K) is a novel approach to induce polyclonal anti-TNF antibodies in immune-mediated inflammatory diseases. This study was performed to transfer the proof of c

Externí odkaz: https://doaj.org/article/f926eea74a0d438b8096e2e881798036

1190-P: IFN-Alpha Kinoid: A Promising Vaccine against Type 1 Diabetes Targeting IFN-alpha in NOD Mice

Autor: Fabien Colaone, Géraldine Grouard-Vogel, Samir Hamdi, Jennifer Da Silva, Agnès Lehuen, Noémie Caillot, Romain Bertrand, Boitard F. Boitard, Jonathan Bonnefoy

Publikováno v: Diabetes. 68

Major elements highlight IFNα implication in type 1 diabetes (T1D) pathogenesis. While there is still no cure for this autoimmune disease, we aimed to evaluate the benefit of IFNα kinoid (IFN-K). This conjugated vaccine consisting of IFNα coupled

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49e042fce054bc07179d50c585da2aaf
https://doi.org/10.2337/db19-1190-p

Interferon α kinoid induces neutralizing anti-interferon α antibodies that decrease the expression of interferon-induced and B cell activation associated transcripts: analysis of extended follow-up data from the interferon α kinoid phase I/II study

Autor: Bernard Lauwerys, Géraldine Grouard-Vogel, Fabien Colaone, François Spertini, Christian Jorgensen, Thérèse Croughs, Estibaliz Lazaro, Julie Ducreux, Camille Roucairol, Frédéric Houssiau, Pierre Vandepapelière, Marion Laborie

Publikováno v: Rheumatology
Rheumatology, Oxford University Press (OUP), 2016, 55 (10), pp.1901-1905. ⟨10.1093/rheumatology/kew262⟩
Rheumatology (Oxford, England)
Rheumatology (Oxford, England), vol. 55, no. 10, pp. 1901-1905

Objective. IFN α Kinoid (IFN-K) is a therapeutic vaccine composed of IFNα2b coupled to a carrier protein. In a phase I/II placebo-controlled trial, we observed that IFN-K significantly decreases the IFN gene signature in whole blood RNA samples fro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f43119e18d0192b98d39fa25d2543d7
https://hal.archives-ouvertes.fr/hal-01864876

Targeting VEGF-A with a vaccine decreases inflammation and joint destruction in experimental arthritis

Autor: Emilie Duvallet, Marie-Christophe Boissier, Nicolas Marival, Emilie Bernier, Nicolas Schall, Nadia Belmellat, Sylviane Muller, Maelle Monteil, Géraldine Grouard-Vogel, Marc Lecouvey, Hanna Hlawaty, Luca Semerano, Eric Assier

Publikováno v: Angiogenesis. 19(1)

Inflammation and angiogenesis are two tightly linked processes in arthritis, and therapeutic targeting of pro-angiogenic factors may contribute to control joint inflammation and synovitis progression. In this work, we explored whether vaccination aga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6979ed638163b11cdca15dd2ab1f6a7
https://pubmed.ncbi.nlm.nih.gov/26419779