Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Géraldine Bouchard"'
Autor:
Georgette Plemper van Balen, Bernard Testa, Catherine a Marca Martinet, Géraldine Bouchard, Giulia Caron, Marianne Reist, Roberta Fruttero, Pierre-Alain Carrupt, Alberto Gasco
Publikováno v:
Medicinal Research Reviews, Vol. 24, No 3 (2004) pp. 299-324
This review discusses liposome/water lipophilicity in terms of the structure of liposomes, experimental methods, and information content. In a first part, the structural properties of the hydrophobic core and polar surface of liposomes are examined i
Autor:
Pierre-Alain Carrupt, Henrik Jensen, Géraldine Bouchard, Sorina M. Ulmeanu, Hubert H. Girault
Publikováno v:
Pharmaceutical Research. 20:1317-1322
Purpose. A new experimental set-up for studying partitioning of ionizable drugs at the interface between two immiscible electrolyte solutions (ITIES) by amperometry is presented. The method is quite general, as it can be applied to any charged drug m
Autor:
Rubin Gulaboski, Fritz Scholz, Géraldine Bouchard, Hubert H. Girault, Pierre-Alain Carrupt, Valentin Mirčeski, Alexandra Galland
Publikováno v:
Physical Chemistry Chemical Physics, Vol. 5, No 17 (2003) pp. 3748-3751
The anionic forms of 26 drugs and organic model compounds have been extensively explored in the n-octanol/ water system using voltammetry at three-phase electrodes. The objective of this study was to validate the ability of this electrochemical syste
Autor:
Zdenek Samec, Henrik Jensen, Géraldine Bouchard, Pierre-Alain Carrupt, Sorina M. Ulmeanu, Hubert H. Girault
Publikováno v:
ResearcherID
Journal of Electroanalytical Chemistry, Vol. 530, No 1-2 (2002) pp. 10-15
Journal of Electroanalytical Chemistry, Vol. 530, No 1-2 (2002) pp. 10-15
Cyclic voltammetry has been used to study the coupling of ion transfer reactions at a liquid membrane. The liquids are either supported by a porous hydrophobic membrane (polyvinylidene difluoride, PVDF) when the organic solvent is non-volatile (o-nit
Autor:
T. Happaerts, Géraldine Bouchard, Didier M. Lambert, Bernard Testa, Johan Wouters, O. Oscari, Frédéric Ooms, Pierre-Alain Carrupt
Publikováno v:
Journal of Medicinal Chemistry, Vol. 45, No 9 (2002) pp. 1748-1756
A set of 29 3-alkyl 5-arylimidazolidinediones (hydantoins) with affinity for the human cannabinoid CB1 receptor was studied for their lipophilicity and conformational properties in order to delineate a pharmacophore. These molecules constitute a new
Autor:
Alessandra Pagliara, Bernard Testa, Véronique Gobry, Pierre-Alain Carrupt, Géraldine Bouchard, Hubert H. Girault
Publikováno v:
Pharmaceutical Research. 19:1150-1159
Purpose. This work examines the lipophilic behavior of various zwitterions and shows how distribution profiles in biphasic systems and ionic partition diagrams may improve our understanding of pH-absorption profiles of drugs.
Autor:
Giulia Caron, Pierre-Alain Carrupt, Giuseppe Ermondi, Georgette Plemper van Balen, Alessandra Pagliara, Géraldine Bouchard, Teresa Grandi, Roberta Fruttero, Bernard Testa
Publikováno v:
Helvetica Chimica Acta, Vol. 84, No 2 (2001) pp. 360-374
The zwitterionic antihistamine cetirizine and its parent drug hydroxyzine as reference compound were examined for their 3D structures and dynamics. After attributing, by NMR spectroscopy, the two basic pK(a) values. the most common conformations for
Autor:
Georgette Plemper van Balen, Pierre-Alain Carrupt, Giulia Caron, Teresa Grandi, Roberta Fruttero, Alessandra Pagliara, Géraldine Bouchard, Giuseppe Ermondi, Bernard Testa
Publikováno v:
Pharmaceutical Research. 18:694-701
Purpose. The partitioning of cetirizine in a phosphatidylcholine liposomes/water system was compared with that of hydroxyzine and acrivastine to gain insight into the mechanisms of interaction of its various electrical species with membranes.
Publikováno v:
Pharmaceutical Research. 18:702-708
Purpose. This work examines whether ion–pairing contributes to the apparent lipophilicity of cations, which is seen by a shake–flask or titrimetic method to be influenced by the nature and concentration of counter–ions.
Publikováno v:
Helvetica Chimica Acta. 83:1465-1474
Sildenafil (Viagra(TM)) was examined for its ionization and lipophilicity by two-phase titration and electrochemistry at the interface between two immiscible electrolyte solutions (ITIES) in the 12-dichloroethane/H2O system. The dissociation constant