Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Gérald Villeneuve"'
Autor:
Nadia Fortin, Carl Saint-Louis, Annick Landry, René Gagnon, Gilles Olsen, Sylvain Bernard, Patrick Bherer, Eric Marsault, Véronique Plourde, Gilles Berthiaume, Martin Brassard, Robert Deziel, Axel Mathieu, Gérald Villeneuve, Xiaowen Peng, Hamid R. Hoveyda, Mark Peterson, Graeme L. Fraser, François Bilodeau, Ruoxi Lan, Shridhar Bhat, Annie Doucet, Maude Gauthier, Yves L. Dory, David Lonergan, Shigui Li, Sylvie Beaubien, Luc Ouellet, Pierre Deslongchamps, Alexandre Drouin, Fabrice Galaud, Sophie Beauchemin, Manon Champagne, Kamel Benakli, Mahesh Ramaseshan, Laurence Foucher, Jean François Pinault, Martin Vezina, Daniel Fortin, Zhigang Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4731-4735
A new method for solid phase parallel synthesis of chemically and conformationally diverse macrocyclic peptidomimetics is reported. A key feature of the method is access to broad chemical and conformational diversity. Synthesis and mechanistic studie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf941f5cc5a05130451a2464ff661573
https://doi.org/10.1016/j.bmcl.2008.06.085
https://doi.org/10.1016/j.bmcl.2008.06.085
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :1897-1904
erythro and threo N-Acetyl-S-p-methylbenzyl-β-phenyl-DL-cysteine methyl esters were obtained by addition of p-methyltoluene-α-thiol to 4-benzylidene-2-methyloxazol-5-one in methanol–tetrahydrofuran under basic conditions. The diastereoisomers wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ac3a6d075a06b4e3410a23b4085278c
https://doi.org/10.1039/p19930001897
https://doi.org/10.1039/p19930001897
Publikováno v:
Bioorganicmedicinal chemistry letters. 13(21)
Rigidified derivatives have been designed and synthesized assuming the g+t conformer of acetylcholine (N-C-C-O=+60 degrees, C-C-O-C=180 degrees ) as active conformation for binding to cytisine sensitive neuronal nicotinic receptors. The SAR of the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f085f6f4f847b590b43284922177bf73
https://pubmed.ncbi.nlm.nih.gov/14552793
https://pubmed.ncbi.nlm.nih.gov/14552793
Publikováno v:
Journal of computer-aided molecular design. 5(6)
The molecular basis underlying the divergent receptor selectivity of two cyclic opioid peptides Tyr-c[N delta-D-Orn2-Gly-Phe-Leu-] (c-ORN) and [D-Pen2,L-Cys5]-enkephalinamide (c-PEN) was investigated using a molecular modeling approach. Ring closure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7fb65a58d185274f51371ddda5ef332
https://pubmed.ncbi.nlm.nih.gov/1667926
https://pubmed.ncbi.nlm.nih.gov/1667926
Publikováno v:
Journal of the Chemical Society, Perkin Transactions 2. :1631
The conformational features associated with the introduction of the methylene-oxy surrogate of the amide bond were explored by studying the crystal and solution conformation of the related model peptides Boc-Val-Leu-OH (1) and Boc-Val-ψ(CH2O)-Leu-OH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec0e63d85fe2bf4a951b58fb9d111dca
https://doi.org/10.1039/p29940001631
https://doi.org/10.1039/p29940001631
Autor:
J.Y. Huot, Alphonso Anusiem, Carmel Jolicoeur, Gérald Villeneuve, Jean-François Lavallée, Ezio Battistel, Rufus Lumry
Publikováno v:
Journal of Solution Chemistry. 17:601-636
A detailed thermodynamic study of water (W)-ethylene glycol (EG) mixtures has been carried out as function of temperature (5, 25 and 45°C) and over the entire composition range. The data comprise heats of mixing, densities, heat capacities and compr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1070c4973f3654234a84ae8f2b6bcfd0
https://doi.org/10.1007/bf00645974
https://doi.org/10.1007/bf00645974
Publikováno v:
Journal of Medicinal Chemistry. 29:1658-1663
The cyclic enkephalin analogue H-Tyr-cyclo[-D-N delta-Orn-Gly-Phe-Leu-] (1-c) and the rigid narcotic alkaloid 7 alpha-[(1R)-1-hydroxy-1-methyl-3-phenylpropyl]-6,14- endo-ethenotetrahydrooripavine (PEO) were studied by using computer graphics methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ebcedfb07068d0a53e26dceeb86ac2
https://doi.org/10.1021/jm00159a016
https://doi.org/10.1021/jm00159a016
Publikováno v:
ChemInform. 18
The cyclic enkephalin analogue H-Tyr-cyclo[-D-N delta-Orn-Gly-Phe-Leu-] (1-c) and the rigid narcotic alkaloid 7 alpha-[(1R)-1-hydroxy-1-methyl-3-phenylpropyl]-6,14- endo-ethenotetrahydrooripavine (PEO) were studied by using computer graphics methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98259aa4560ddcaa3dea36e18c85f0a6
https://doi.org/10.1002/chin.198706308
https://doi.org/10.1002/chin.198706308