Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers

Autor: Cyril Goudet, Xavier Pannecoucke, Amélie S. Tora, Gérald Lemonnier, Philippe Jubault, Jean-Philippe Pin, Pavel Ivashkin

Publikováno v: Bioorganic and Medicinal Chemistry Letters
Bioorganic and Medicinal Chemistry Letters, Elsevier, 2015, 25 (12), pp.2523-2526. ⟨10.1016/j.bmcl.2015.04.043⟩

International audience; The four stereoisomers of 1-amino-2-fluoro-2-(phosphonomethyl)cyclopropane-1-carboxylic acid (FAP4) were synthesized via diastereoselective Rh(II)-catalysed cyclopropanation of a phosphonylated fluoroalkene. Different isomer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d9e8f088fc91bb49e262d5a7e2688ec
https://doi.org/10.1016/j.bmcl.2015.04.043

α-Amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: Synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4

Autor: Philippe Jubault, Jean-Charles Quirion, Gérald Lemonnier, Cédric Lion, Cyril Goudet, Jean-Philippe Pin

Publikováno v: Bioorganic and Medicinal Chemistry
Bioorganic and Medicinal Chemistry, Elsevier, 2012, 20 (15), pp.4716-26. ⟨10.1016/j.bmc.2012.06.006⟩

International audience; Herein we describe the diastereoselective synthesis of glutamic acid analogs and the evaluation of their agonist activity towards metabotropic glutamate receptor subtype 4 (mGluR4). These analogs are based on a monofluorinated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5869717a25468133c8d7e4b3f83d93
https://doi.org/10.1016/j.bmc.2012.06.006

ChemInform Abstract: Rhodium-Catalyzed Cyclopropanation of Fluorinated Olefins: A Straightforward Route to Highly Functionalized Fluorocyclopropanes

Autor: Xavier Pannecoucke, André B. Charette, Gérald Lemonnier, Pavel Ivashkin, Helene Beucher, Amandine Pons, Thomas Poisson, Philippe Jubault

Publikováno v: ChemInform. 46

An efficient access to highly functionalized monofluorocyclopropanes is described. The developed methodology allowed straightforward access to a large panel of polysubstituted fluorinated cyclopropanes in good to excellent yields and good diastereose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1096a675be3e7b8efaa4569ab5d8548a
https://doi.org/10.1002/chin.201533086

Rhodium-Catalyzed Cyclopropanation of Fluorinated Ole ns: A Straightforward Route to Highly Functionalized Fluorocyclopropanes

Autor: Helene Beucher, Xavier Pannecoucke, Amandine Pons, Philippe Jubault, Thomas Poisson, André B. Charette, Pavel Ivashkin, Gérald Lemonnier

Publikováno v: Organic Letters
Organic Letters, American Chemical Society, 2015, 17 (7), pp.1790-1793. ⟨10.1021/acs.orglett.5b00576⟩

International audience; An efficient access to highly functionalized monofluorocyclopropanes is described. The developed methodology allowed straightforward access to a large panel of polysubstituted fluorinated cyclopropanes in good to excellent yie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b260ee9604ce6968a93a39ea9460b3b
https://hal.archives-ouvertes.fr/hal-01149632

ChemInform Abstract: Efficient Access to Fluorinated Homoallylic Alcohols Through an Indium Promoted Fluoroallylation Reaction

Autor: Muriel Sebban, Thomas Poisson, Xavier Pannecoucke, Nathalie Van Hijfte, Gérald Lemonnier, Samuel Couve-Bonnaire

Publikováno v: ChemInform. 45

Herein, an efficient access to fluorinated homoallylic alcohol is reported. The fluorinated alcohols were obtained in good to excellent yield using indium and halo-fluorinated allylic derivatives. The developed methodology using γ-substituted halo-f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc4d2b22b2a645836bb5d21b488e6236
https://doi.org/10.1002/chin.201439066