Výsledky vyhledávání - "Gérald Leca"

BimL upregulation induced by BCR cross-linking in BL41 Burkitt’s lymphoma results from a splicing mechanism of the BimEL mRNA

Autor: Cyril Clybouw, Gérald Leca, Marie-Thérèse Auffredou, Aimé Vazquez, Bouchra ElMchichi, Abbas Hadji

Publikováno v: Biochemical and Biophysical Research Communications. 383:32-36

B lymphocyte receptor-mediated apoptosis is associated with increased expression of the BimL isoform of Bim. The mechanisms involved in the regulation of BimL protein expression are still unknown. We report that BimL expression following BCR activati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fa2a2396005f235bc501765d35b8383
https://doi.org/10.1016/j.bbrc.2009.03.123

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EBV Infection of Human B Lymphocytes Leads to Down-Regulation of Bim Expression: Relationship to Resistance to Apoptosis

Autor: Cyril Clybouw, Shahul Mouhamad, Aimé Vazquez, Marie Françoise Bourgeade, Bouchra Mchichi, Marie Thérèse Auffredou, Surendra Sharma, Gérald Leca

Publikováno v: The Journal of Immunology. 175:2968-2973

EBV infects a large proportion of the human population worldwide and is one of the major viruses with human B lymphocyte tropism. It can immortalize human B lymphocytes and controls their resistance to apoptosis. EBV infection is associated with seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf87e6f2ac87ad967d39439d9169feb
https://doi.org/10.4049/jimmunol.175.5.2968

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p38-mediated Regulation of an Fas-associated Death Domain Protein-independent Pathway Leading to Caspase-8 Activation during TGFβ-induced Apoptosis in Human Burkitt Lymphoma B Cells BL41

Autor: Surendra Sharma, Aimé Vazquez, Nicolas Schrantz, Gérald Leca, Shahul Mouhamad, Marie-Françoise Bourgeade

Publikováno v: Molecular Biology of the Cell. 12:3139-3151

On binding to its receptor, transforming growth factor beta (TGFbeta) induces apoptosis in a variety of cells, including human B lymphocytes. We have previously reported that TGFbeta-mediated apoptosis is caspase-dependent and associated with activat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b4f720a45e64eb70c70ebaa0b94abac
https://doi.org/10.1091/mbc.12.10.3139

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Zinc-mediated regulation of caspases activity: dose-dependent inhibition or activation of caspase-3 in the human Burkitt lymphoma B cells (Ramos)

Autor: Laurence Besnault, Marie-Françoise Bourgeade, Nicolas Schrantz, Marie-Thérèse Auffredou, Aimé Vazquez, Gérald Leca

Publikováno v: Cell Death & Differentiation. 8:152-161

Divalent cations, including Zinc and Manganese ions, are important modulators of cell activation. We investigated the ability of these two divalent cations to modulate apoptosis in human Burkitt lymphoma B cells line (Ramos). We found that Zinc (from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1737b8c95d32caa43bb3c51881b7f06a
https://doi.org/10.1038/sj.cdd.4400772

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Cdk2 associates with MAP Kinase in vivo and its nuclear translocation is dependent on MAP Kinase activation in IL-2-dependent Kit 225 T lymphocytes

Autor: Gérald Leca, Marie-Thérèse Auffredou, Arlette Pesty, Aimé Vazquez, Dominique Blanchard, Shahul Mouhamad, Jacques Bertoglio

Publikováno v: Oncogene. 19:4184-4189

Cell proliferation is controlled by cdk2 which in association with cyclin E and A regulates G1/S transition and S phase progression. cdk2 activation is dependent on its localization in the nucleus where regulatory mediators are found. We report that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f281cc2b81b869ca53de49b7cc5afde9
https://doi.org/10.1038/sj.onc.1203761

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Manganese induces apoptosis of human B cells: caspase-dependent cell death blocked by Bcl-2

Autor: Nicolas Schrantz, Marie-Thérèse Auffredou, Aimé Vazquez, Gérald Leca, Françoise Mitenne, Dominique Blanchard

Publikováno v: Cell Death & Differentiation. 6:445-453

Manganese ions block apoptosis of phagocytes induced by various agents. The prevention of apoptosis was attributed to the activation of manganous superoxide dismutase (Mn-SOD) and to the antioxidant function of free Mn2+ cations. However, the effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baf0fb7a3a3ff2616b8bd1068fb1205d
https://doi.org/10.1038/sj.cdd.4400508

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Significant enlargement of a specific subset of CD3+CD8+ peripheral blood leukocytes mediating cytotoxic T-lymphocyte activity during human immunodeficiency virus infection

Autor: Djaouida Bengoufa, Claire Rabian, Gérald Leca, Armand Bensussan, Valérie Schiavon, Laurence Boumsell

Publikováno v: Proceedings of the National Academy of Sciences. 90:9427-9430

We have obtained a monoclonal antibody termed BY55 that defines an 80-kDa cell-surface structure on a subset of circulating peripheral blood mononucleocytes. This structure, which was not detected on most cell lines or activated lymphocytes, was expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a022d24c158a56795353e6f5b9ac576b
https://doi.org/10.1073/pnas.90.20.9427

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A novel 80-kD cell surface structure identifies human circulating lymphocytes with natural killer activity

Autor: Gérald Leca, Indra Gusti Mansur, Armand Bensussan, Hassina Maiza, Valérie Schiavon, Laurence Boumsell

Publikováno v: The Journal of Experimental Medicine

Human lymphocytes with natural killer (NK) activity, including most activated gamma/delta+ T lymphocytes, recognize and lyse tumor target cells without requiring recognition of major histocompatibility complex antigen. However, unlike gamma/delta+ T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22654275d6a10e88b07bcc524880eda
http://europepmc.org/articles/PMC2191151

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