Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Gérald, Lelais"'
Autor:
Laura J, Kingsley, Xiaohui, He, Matthew, McNeill, John, Nelson, Victor, Nikulin, Zhiwei, Ma, Wenshuo, Lu, Vicki W, Zhou, Mari, Manuia, Andreas, Kreusch, Mu-Yun, Gao, Darbi, Witmer, Mei-Ting, Vaillancourt, Min, Lu, Sarah, Greenblatt, Christian, Lee, Ajay, Vashisht, Steven, Bender, Glen, Spraggon, Pierre-Yves, Michellys, Yong, Jia, Jacob R, Haling, Gérald, Lelais
Publikováno v:
Journal of medicinal chemistry. 64(8)
LONP1 is an AAA+ protease that maintains mitochondrial homeostasis by removing damaged or misfolded proteins. Elevated activity and expression of LONP1 promotes cancer cell proliferation and resistance to apoptosis-inducing reagents. Despite the impo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e665e6a49bed89fff37af4eae908565f
https://pubmed.ncbi.nlm.nih.gov/33821636
https://pubmed.ncbi.nlm.nih.gov/33821636
Autor:
Gérald, Lelais, Robert, Epple, Thomas H, Marsilje, Yun O, Long, Matthew, McNeill, Bei, Chen, Wenshuo, Lu, Jaganmohan, Anumolu, Sangamesh, Badiger, Badry, Bursulaya, Michael, DiDonato, Rina, Fong, Jose, Juarez, Jie, Li, Mari, Manuia, Daniel E, Mason, Perry, Gordon, Todd, Groessl, Kevin, Johnson, Yong, Jia, Shailaja, Kasibhatla, Chun, Li, John, Isbell, Glen, Spraggon, Steven, Bender, Pierre-Yves, Michellys
Publikováno v:
Journal of medicinal chemistry. 59(14)
Over the past decade, first and second generation EGFR inhibitors have significantly improved outcomes for lung cancer patients with activating mutations in EGFR. However, both resistance through a secondary T790M mutation at the gatekeeper residue a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e6581993755c96201e35fb6c7ecb996e
https://pubmed.ncbi.nlm.nih.gov/27433829
https://pubmed.ncbi.nlm.nih.gov/27433829
Publikováno v:
Helvetica Chimica Acta. 91:2035-2056
The new electrophilic trifluoromethylating 1-(trifluoromethyl)-benziodoxole reagents A and B (Scheme 1) have been used to selectively attach CF3 groups to the S-atom of cysteine side chains of α- and β-peptides (up to 13-residues-long; products 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c8cab46c338cf86da3cdbf34d5403ab
https://doi.org/10.1002/hlca.200890217
https://doi.org/10.1002/hlca.200890217
Publikováno v:
Helvetica Chimica Acta. 87:1545-1560
(S)-β2-Homoamino acids with the side chains of Asp, Glu, Asn, and Gln have been prepared and suitably protected (N-Fmoc, CO2tBu, CONHTrt) for solid-phase peptide syntheses. The key steps of the syntheses are: N-acylation of 5,5-diphenyl-4-isopropyl-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::743aa09700fb747040416d2009389705
https://doi.org/10.1002/hlca.200490142
https://doi.org/10.1002/hlca.200490142
Autor:
Dieter Seebach, Gérald Lelais
Publikováno v:
Biopolymers. 76:206-243
Although they are less abundant than their alpha-analogues, beta-amino acids occur in nature both in free form and bound to peptides. Oligomers composed exclusively of beta-amino acids (so-called beta-peptides) might be the most thoroughly investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94bffcc2bc45db34c7fdc9dd66d835c2
https://doi.org/10.1002/bip.20088
https://doi.org/10.1002/bip.20088
Autor:
Radovan Šebesta, Bernd Schweizer, Gérald Lelais, Laurent Schaeffer, Peter Micuch, Sascha Kopp, Yogesh R. Mahajan, Dieter Seebach, Delphine Josien, François Gessier, Pascal Bindschädler, Corinna Jäger
Publikováno v:
Helvetica Chimica Acta. 86:1852-1861
Multigram amounts of suitably protected β2-amino acids with 17 of the 20 proteinogenic side chains are prepared by diastereoselective reactions of Li, B, or Ti enolates of the corresponding 3-acyl-4-isopropyl-5,5-diphenyloxazolidin-2-ones (acyl-DIOZ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a8c4f82b2242cf1bb797ca50243fae1
https://doi.org/10.1002/hlca.200390149
https://doi.org/10.1002/hlca.200390149
Autor:
Gérald Lelais, David W. C. MacMillan
Publikováno v:
New Frontiers in Asymmetric Catalysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c4f1d490a704ee268f8d9d4508f3551
https://doi.org/10.1002/9780470098004.ch11
https://doi.org/10.1002/9780470098004.ch11
Autor:
Gérald, Lelais, Dieter, Seebach
Publikováno v:
Biopolymers. 76(3)
Although they are less abundant than their alpha-analogues, beta-amino acids occur in nature both in free form and bound to peptides. Oligomers composed exclusively of beta-amino acids (so-called beta-peptides) might be the most thoroughly investigat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5a85c9d29ef6c4357fb7cb45b8721c81
https://pubmed.ncbi.nlm.nih.gov/15148683
https://pubmed.ncbi.nlm.nih.gov/15148683
Autor:
Dieter Seebach, Gérald Lelais
Publikováno v:
Peptides: The Wave of the Future ISBN: 9789401039055
It has been demonstrated that short oligomers derived from β-amino acids (β-peptides) can fold into well-ordered secondary structures like helices, turns and sheets [1]. Furthermore, they show an outstanding stability against a large range of prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3334bb777ac2292161683aa7faae3729
https://doi.org/10.1007/978-94-010-0464-0_269
https://doi.org/10.1007/978-94-010-0464-0_269