Zobrazeno 1 - 10
of 482
pro vyhledávání: '"Gérald, Guillaumet"'
Publikováno v:
Biomolecules, Vol 14, Iss 11, p 1419 (2024)
A comprehensive review of advances in the synthesis and biological applications of enoxacin (1, referred to as ENX)-based compounds is presented. ENX, a second-generation fluoroquinolone (FQ), is a prominent 1,8-naphthyridine containing compounds stu
Externí odkaz:
https://doaj.org/article/1bc8524f7c984cb0bcb0785165beaef0
Autor:
Abdelmoula El Abbouchi, Khaoula Mkhayar, Souad Elkhattabi, Nabil El Brahmi, Marie-Aude Hiebel, Jérôme Bignon, Gérald Guillaumet, Franck Suzenet, Saïd El Kazzouli
Publikováno v:
Molecules, Vol 29, Iss 7, p 1437 (2024)
In the present work, the synthesis of new ethacrynic acid (EA) derivatives containing nitrogen heterocyclic, urea, or thiourea moieties via efficient and practical synthetic procedures was reported. The synthesised compounds were screened for their a
Externí odkaz:
https://doaj.org/article/fdf8dde43bea4853a0b9e3e4ad474c90
Autor:
Abdelmoula El Abbouchi, Nabil El Brahmi, Marie-Aude Hiebel, Hamza Ghammaz, Elmostafa El Fahime, Jérôme Bignon, Gérald Guillaumet, Franck Suzenet, Saïd El Kazzouli
Publikováno v:
Molecules, Vol 28, Iss 2, p 910 (2023)
The present study aims to report the design, synthesis, and biological activity of new ethacrynic acid (EA) analogs (6–10) obtained by the double modulation of the carboxylic acid moiety and the aromatic ring with the aim to increase the chemical r
Externí odkaz:
https://doaj.org/article/0781e66ac80c490283c6d670e360f1d0
Autor:
Otmane Bourzikat, Abdelmoula El Abbouchi, Hamza Ghammaz, Nabil El Brahmi, Elmostfa El Fahime, Arnaud Paris, Richard Daniellou, Franck Suzenet, Gérald Guillaumet, Saïd El Kazzouli
Publikováno v:
Molecules, Vol 27, Iss 16, p 5238 (2022)
In the present study, new 2-phenyl-5,6,7,8-tetrahydroimidazo [1,2-b]pyridazines bearing sulfonamides were synthesized, characterized and evaluated for their anticancer activities. The structures of these derivatives were elucidated by 1H NMR, 13C NMR
Externí odkaz:
https://doaj.org/article/8fc3ca29fdfa4dc9ab282d857c3b768c
Publikováno v:
Molecules, Vol 26, Iss 19, p 5763 (2021)
The regioselective C-H functionalization of the five-membered ring of the 6,5-fused heterocyclic systems is nowadays well documented due to its high reactivity compared to the six-membered ring. So, developing new procedures of C-H functionalization
Externí odkaz:
https://doaj.org/article/504aba4e78204e5d8efcf642b7789a32
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
General and efficient approaches for the synthesis of new 5-amino and 5-iminoimidazo[1,2-a]imidazoles were developed through a three-component reaction of 1-unsubstituted 2-aminoimidazoles with various aldehydes and isocyanides mediated by zirconium(
Externí odkaz:
https://doaj.org/article/38ae68e0f6e54f48beff9a764c582738
Autor:
Khadija Gambouz, Abdelmoula El Abbouchi, Sarah Nassiri, Franck Suzenet, Mostapha Bousmina, Mohamed Akssira, Gérald Guillaumet, Saïd El Kazzouli
Publikováno v:
Molecules, Vol 25, Iss 12, p 2820 (2020)
The C3 direct arylation of 1H-indazole and 1H-7-azaindazole has been a significant challenge due to the lack of the reactivity at this position. In this paper, we describe a mild and an efficient synthesis of new series of C3-aryled 1H-indazoles and
Externí odkaz:
https://doaj.org/article/6aad5dbc50664a88be96b462eec6b0fd
Publikováno v:
Molecules, Vol 25, Iss 9, p 2062 (2020)
An efficient and original synthesis of various 3,5-disubstituted 7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidines is reported. A library of compounds diversely substituted in C-3 and C-5 positions was easily prepared from a common starting material, 3-b
Externí odkaz:
https://doaj.org/article/0479dba10a734a7ba0c97ec106300b8e
Publikováno v:
ChemistrySelect. 6:8985-9011
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57f8fc546697c4203822bce25ce0c8fd
https://doi.org/10.1002/slct.202101636
https://doi.org/10.1002/slct.202101636
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 282-286 (2014)
Substituted 3,4-dihydro-1,8-naphthyridin-2(1H)-ones have been synthesized with the inverse electron-demand Diels–Alder reaction from 1,2,4-triazines bearing an acylamino group with a terminal alkyne side chain. Alkynes were first subjected to the S
Externí odkaz:
https://doaj.org/article/a6b25064c9674d75b6f6fe3339c3d13e