A Phosphotriester-Masked Dideoxy-cGAMP Derivative as a Cell-Permeable STING Agonist.

Autor: Halbritter AJ; Department of Chemistry, Institute for Chemical Epigenetics , Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany., Gärtner YV; Department of Chemistry, Institute for Chemical Epigenetics , Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany., Nabiev J; Department of Chemistry, Institute for Chemical Epigenetics , Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany., Hernichel F; Department of Chemistry, Institute for Chemical Epigenetics , Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany., Ganazzoli G; Department of Chemistry, Institute for Chemical Epigenetics , Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany., Özdemir D; Department of Chemistry, Institute for Chemical Epigenetics , Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany., Pappa A; Department of Chemistry, Institute for Chemical Epigenetics , Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany., Veth S; Department of Chemistry, Institute for Chemical Epigenetics , Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany., Stazzoni S; Department of Chemistry, Institute for Chemical Epigenetics , Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany., Müller M; Department of Chemistry, Institute for Chemical Epigenetics , Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany., Hornung V; Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Feodor-Lynen-Str. 25, 81377, Munich, Germany., Carell T; Department of Chemistry, Institute for Chemical Epigenetics , Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Nov 12, pp. e202416353. Date of Electronic Publication: 2024 Nov 12.

Suppression of SARS-CoV-2 Replication with Stabilized and Click-Chemistry Modified siRNAs.

Autor: Traube FR; Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany., Stern M; Max von Pettenkofer Institute and Gene Center, Ludwig-Maximilians-Universität München, Feodor-Lynen-Straße 25, 81377, Munich, Germany., Tölke AJ; Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany., Rudelius M; Institute of Pathology, Ludwig-Maximilians-Universität München, Marchioninistr. 68, 81377, Munich, Germany., Mejías-Pérez E; Max von Pettenkofer Institute and Gene Center, Ludwig-Maximilians-Universität München, Feodor-Lynen-Straße 25, 81377, Munich, Germany., Raddaoui N; Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany., Kümmerer BM; Institute of Virology, Universitätsklinikum Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.; German Center for Infection Research (DZIF), Partner Site Cologne/Bonn, 53127, Bonn, Germany., Douat C; Department of Pharmacy, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany., Streshnev F; Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany., Albanese M; Max von Pettenkofer Institute and Gene Center, Ludwig-Maximilians-Universität München, Feodor-Lynen-Straße 25, 81377, Munich, Germany., Wratil PR; Max von Pettenkofer Institute and Gene Center, Ludwig-Maximilians-Universität München, Feodor-Lynen-Straße 25, 81377, Munich, Germany., Gärtner YV; Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany., Nainytė M; Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany., Giorgio G; Department of Ophthalmology, University Hospital, Ludwig-Maximilians-Universität München, 80336, Munich, Germany., Michalakis S; Department of Ophthalmology, University Hospital, Ludwig-Maximilians-Universität München, 80336, Munich, Germany., Schneider S; Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany., Streeck H; Institute of Virology, Universitätsklinikum Bonn, Venusberg-Campus 1, 53127, Bonn, Germany., Müller M; Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany., Keppler OT; Max von Pettenkofer Institute and Gene Center, Ludwig-Maximilians-Universität München, Feodor-Lynen-Straße 25, 81377, Munich, Germany., Carell T; Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, Munich, Germany.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2022 Sep 19; Vol. 61 (38), pp. e202204556. Date of Electronic Publication: 2022 Aug 12.