Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Gábor Petho"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17143 (2023)
Epigenetics deals with alterations to the gene expression that occur without change in the nucleotide sequence in the DNA. Various covalent modifications of the DNA and/or the surrounding histone proteins have been revealed, including DNA methylation
Externí odkaz:
https://doaj.org/article/0c233a6c57b1479a8daac2caf76a106e
Autor:
Peter W. Reeh, Gábor Petho
Publikováno v:
Physiological Reviews. 92:1699-1775
Peripheral mediators can contribute to the development and maintenance of inflammatory and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two mechanisms. Activation or excitation by these substances of nociceptive nerve ending
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890d63752ed0468f4793b3801b0baff5
https://doi.org/10.1152/physrev.00048.2010
https://doi.org/10.1152/physrev.00048.2010
Publikováno v:
Current Topics in Medicinal Chemistry. 11:2253-2263
Release of somatostatin into the circulation from the activated TRPV1-expressing nociceptors revealed by antidromic stimulation of dorsal roots in the rat pinpointed to a novel potential drug target on these nociceptors. The review summarizes the fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c31a81c3bc1d3e9f4c40cc2ee43742f9
https://doi.org/10.2174/156802611796904852
https://doi.org/10.2174/156802611796904852
Autor:
Ágnes Kis-Varga, András Visegrády, Kata Bölcskei, László Dézsi, Valéria Tékus, Csilla Horváth, Gábor Petho, János Szolcsányi, Eva Szentirmay
Publikováno v:
European Journal of Pharmacology. 641:135-141
The transient receptor potential vanilloid 1 (TRPV1) receptor is activated by noxious heat, various endogenous mediators and exogenous irritants. The aim of the present study was to compare three TRPV1 receptor antagonists (SB705498, BCTC and AMG9810
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5812e43983d143c6e386b186406567ed
https://doi.org/10.1016/j.ejphar.2010.05.052
https://doi.org/10.1016/j.ejphar.2010.05.052
Publikováno v:
Life Sciences. 81:1685-1693
The bradykinin-induced sensitization of cutaneous nociceptors to heat was previously shown to be abolished by cyclooxygenase blockade suggesting that endogenous prostaglandins exerted a heat-sensitizing action. The present study aimed at investigatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2abd3935fbb17d139ade2f78bdbf8e14
https://doi.org/10.1016/j.lfs.2007.10.001
https://doi.org/10.1016/j.lfs.2007.10.001
Publikováno v:
European Journal of Pharmacology. 564:80-87
Conventional thermonociceptive tests are based on measurement of the latency of nocifensive reactions evoked by constant, suprathreshold heat stimuli. In the present study, a novel, increasing-temperature water bath was developed for determination of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9c37739b649ed26a6a8fb10f90e95cc
https://doi.org/10.1016/j.ejphar.2007.01.097
https://doi.org/10.1016/j.ejphar.2007.01.097
Autor:
Zsuzsanna Helyes, Daniel Keszthelyi, Katalin Sándor, Kata Bölcskei, Rita Börzsei, Árpád Szabó, Gábor Petho, Balázs Jakab, József Németh, János Szolcsányi, Erika Pintér, Angelika Varga, Krisztián Elekes
Publikováno v:
European Journal of Pharmacology. 517:35-44
The TRPV1 capsaicin receptor is an integrator molecule on primary afferent neurones participating in inflammatory and nociceptive processes. The present paper characterizes the effects of JYL1421 (SC0030), a TRPV1 receptor antagonist, on capsaicin-ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cfd38ae836da11070581c0e8e9c6cf7
https://doi.org/10.1016/j.ejphar.2005.05.002
https://doi.org/10.1016/j.ejphar.2005.05.002
Autor:
Örs Péter Horváth, Loránd Barthó, László Illényi, Riccardo Patacchini, Ulrike Holzer-Petsche, Gábor Petho, Andras Antal, Zsófia Lázár, Rita Benkó, Peter Holzer, Sarolta Undi
Publikováno v:
European Journal of Pharmacology. 500:143-157
Studying the visceral effects of the sensory stimulant capsaicin is a useful and relatively simple tool of neurotransmitter identification and has been used for this purpose for approximately 25 years in the authors' and other laboratories. We believ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed84a712fdefc96c8adeb226d15a92b
https://doi.org/10.1016/j.ejphar.2004.07.020
https://doi.org/10.1016/j.ejphar.2004.07.020
Publikováno v:
Pain. 109:284-290
Capsaicin antagonists including ruthenium red, capsazepine and iodo-resiniferatoxin (I-RTX) have recently been shown to inhibit the activation by noxious heat of the capsaicin receptor (TRPV1) expressed in non-neuronal host cells, and natively, in cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9a51909d632a0838073c71d7aa83d9
https://doi.org/10.1016/j.pain.2004.01.038
https://doi.org/10.1016/j.pain.2004.01.038
Autor:
György Hajós, Zsuzsanna Riedl, Kata Bölcskei, Angelika Varga, Zoltán Sándor, Gábor Petho, Róbert Almási, János Szolcsányi, G. Czéh
Publikováno v:
Neuroscience Letters. 361:155-158
Effects of the endogenous lipid N-oleoyldopamine (OLDA) were analyzed on the rTRPV1-expressing HT1080 human fibrosarcoma cell line (HT5-1), on cultured rat trigeminal neurons, on the noxious heat threshold of rats and on nocifensive behavior of TRPV1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e1275d9759c54692cc63c803acd9c9
https://doi.org/10.1016/j.neulet.2003.12.025
https://doi.org/10.1016/j.neulet.2003.12.025