Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Gábor Heltovics"'
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Investigations of the mechanism behind the rapid absorption of nano-amorphous abiraterone acetate
Autor: Tamás Solymosi, Orsolya Basa-Dénes, Réka Angi, Tamás Jordán, Hristos Glavinas, Andrea Ujhelyi, Gábor Heltovics, Zsolt Ötvös
Publikováno v: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 129
Abiraterone acetate is indicated for patients with metastatic castration resistant prostate cancer. The marketed drug product (Zytiga®) exhibits very low bioavailability in the fasted state and a substantial positive food effect. We recently develop
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f11d8ba568f3a02ee098225b9a5d93
https://pubmed.ncbi.nlm.nih.gov/30610953
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3
Novel formulation of abiraterone acetate might allow significant dose reduction and eliminates substantial positive food effect
Autor: Zsolt Ötvös, Ann Church, Hristos Glavinas, Tamás Jordán, László Molnár, Tamás Solymosi, John McDermott, Stuart Mair, Genovéva Filipcsei, Vanessa Zann, Betti Ordasi, Gábor Heltovics, Réka Angi
Publikováno v: Cancer chemotherapy and pharmacology. 80(4)
Zytiga (abiraterone acetate, AA) is known to exhibit very low bioavailability and a significant positive food effect in men. The unfavorable pharmacokinetic properties are attributed to the inadequate and variable dissolution of the compound. Using a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::774ca1f095e5574eab78587da6d9e00f
https://pubmed.ncbi.nlm.nih.gov/28776077
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4
Development of an abiraterone acetate formulation with improved oral bioavailability guided by absorption modeling based on in vitro dissolution and permeability measurements
Autor: Réka Angi, Tamás Solymosi, Soma Ránky, Zsolt Ötvös, Betti Ordasi, Tamás Jordán, László Molnár, Gábor Heltovics, Sándor Semsey, Genovéva Filipcsei, Hristos Glavinas
Publikováno v: International journal of pharmaceutics. 532(1)
Particle size reduction of drug crystals in the presence of surfactants (often called "top-down" production methods) is a standard approach used in the pharmaceutical industry to improve bioavailability of poorly soluble drugs. Based on the mathemati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bca34ae9f3ca725dce65674fc7894c1
https://pubmed.ncbi.nlm.nih.gov/28919099
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7
Sirolimus formulation with improved pharmacokinetic properties produced by a continuous flow method
Autor: Gábor Heltovics, Orsolya Basa-Dénes, Hristos Glavinas, Soma Ránky, Zsolt Ötvös, Réka Angi, Tamás Solymosi, Genovéva Filipcsei
Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 94
The oral bioavailability of Sirolimus is limited by poor dissolution of the compound in the gastrointestinal tract resulting in a low bioavailability and large inter-individual differences in blood levels. Several different formulation approaches wer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74034368c3c661885641ffe78a0b3e95
https://pubmed.ncbi.nlm.nih.gov/26003815
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8
Novel continuous flow technology for the development of a nanostructured aprepitant formulation with improved pharmacokinetic properties
Autor: Genovéva Filipcsei, Betti Ordasi, Tamás Solymosi, Réka Angi, Ferenc Darvas, Gábor Heltovics, Hristos Glavinas, Zsolt Ötvös
Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 86(3)
The oral bioavailability of Aprepitant is limited by poor dissolution of the compound in the gastrointestinal tract which is more prominent in the fasted state resulting in significant positive food effect. Due to the low aqueous solubility of the ac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80989054aa880631301756ea806a35d3
https://pubmed.ncbi.nlm.nih.gov/24161498
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