Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Gábor, Paragi"'
Autor:
Isaac Kinyua Njangiru, Noémi Bózsity-Faragó, Vivien Erzsébet Resch, Gábor Paragi, Éva Frank, György T. Balogh, István Zupkó, Renáta Minorics
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 622 (2024)
The clinical application of 2-methoxyestradiol (2ME) in cancer therapy has been limited by its low solubility and rapid metabolism. Derivatives of 2ME have been synthesised to enhance bioavailability and decrease hepatic metabolism. Compound 4a, an a
Externí odkaz:
https://doaj.org/article/afb882dda7f946a8b6d7d0873b560d71
Autor:
Noémi Bózsity, Viktória Nagy, Johanna Szabó, Balázs Pálházi, Zoltán Kele, Vivien Resch, Gábor Paragi, István Zupkó, Renáta Minorics, Erzsébet Mernyák
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4274 (2024)
Directed structural modifications of natural products offer excellent opportunities to develop selectively acting drug candidates. Natural product hybrids represent a particular compound group. The components of hybrids constructed from different mol
Externí odkaz:
https://doaj.org/article/cdf80854a1f5439bad03d3851450f7a1
Autor:
Hazhmat Ali, Péter Traj, Gábor J. Szebeni, Nikolett Gémes, Vivien Resch, Gábor Paragi, Erzsébet Mernyák, Renáta Minorics, István Zupkó
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6625 (2023)
Cervical carcinoma is one of the most frequent malignant gynecological cancers in women of reproductive age. Because of the poor tolerability of currently available chemotherapeutic agents, efforts have been focused on developing innovative molecules
Externí odkaz:
https://doaj.org/article/b75fba85d6d440e291bb454e8c72a5be
Autor:
Attila Tököli, Brigitta Bodnár, Ferenc Bogár, Gábor Paragi, Anasztázia Hetényi, Éva Bartus, Edit Wéber, Zsófia Hegedüs, Zoltán Szabó, Gábor Kecskeméti, Gerda Szakonyi, Tamás A. Martinek
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1032 (2023)
Single-stranded DNA-binding protein (SSB) is a bacterial interaction hub and an appealing target for antimicrobial therapy. Understanding the structural adaptation of the disordered SSB C-terminus (SSB-Ct) to DNA metabolizing enzymes (e.g., ExoI and
Externí odkaz:
https://doaj.org/article/171a5d32aa4d46fab92fec3fbf67804e
Autor:
Maša Sinreih, Rebeka Jójárt, Zoltán Kele, Tomaž Büdefeld, Gábor Paragi, Erzsébet Mernyák, Tea Lanišnik Rižner
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1499-1507 (2021)
Enzymes AKR1C regulate the action of oestrogens, androgens, and progesterone at the pre-receptor level and are also associated with chemo-resistance. The activities of these oestrone halides were investigated on recombinant AKR1C enzymes. The oestron
Externí odkaz:
https://doaj.org/article/85552082a3ce4fee999b489015b2a35d
Autor:
Erzsébet Mernyák, Sándor Bartha, Lili Kóczán, Rebeka Jójárt, Vivien Resch, Gábor Paragi, Máté Vágvölgyi, Attila Hunyadi, Bella Bruszel, István Zupkó, Renáta Minorics
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 1931-1937 (2021)
Microwave-assisted phospha-Michael addition reactions were carried out in the 13α-oestrone series. The exocyclic 16-methylene-17-ketones as α,β-unsaturated ketones were reacted with secondary phosphine oxides as nucleophilic partners. The addition
Externí odkaz:
https://doaj.org/article/cf583eaeec9e45a3aa656d5aef85ad16
Autor:
Rebeka Jójárt, Seyyed Ashkan Senobar Tahaei, Péter Trungel-Nagy, Zoltán Kele, Renáta Minorics, Gábor Paragi, István Zupkó, Erzsébet Mernyák
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 58-67 (2021)
2- or 4-Substituted 3-N-benzyltriazolylmethyl-13α-oestrone derivatives were synthesised via bromination of ring A and subsequent microwave-assisted, Pd-catalysed C(sp2)–P couplings. The antiproliferative activities of the newly synthesised bromina
Externí odkaz:
https://doaj.org/article/c0787edc2150496687f0aa73c57bbf21
Publikováno v:
New Journal of Physics, Vol 25, Iss 7, p 073001 (2023)
We present a general mathematical procedure to handle interactions described by a Morse potential in the presence of a strong harmonic excitation. We account for permanent and field-induced terms and their gradients in the dipole moment function, and
Externí odkaz:
https://doaj.org/article/6eb8472a215f44738166046b25e78fe3
Autor:
Édua Kovács, Hazhmat Ali, Renáta Minorics, Péter Traj, Vivien Resch, Gábor Paragi, Bella Bruszel, István Zupkó, Erzsébet Mernyák
Publikováno v:
Molecules, Vol 28, Iss 3, p 1196 (2023)
Novel 13α-estrone derivatives have been synthesized via direct arylation of the phenolic hydroxy function. Chan–Lam couplings of arylboronic acids with 13α-estrone as a nucleophilic partner were carried out under copper catalysis. The antiprolife
Externí odkaz:
https://doaj.org/article/a3ec26607c184587b7bd532a93501e55
Publikováno v:
Clinical & Translational Immunology, Vol 9, Iss 12, Pp n/a-n/a (2020)
Abstract Objectives Bacillus Calmette–Guérin (BCG) vaccination has been implicated in protection against severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) and as a non‐specific immunisation method against the virus. We therefore
Externí odkaz:
https://doaj.org/article/313822e749aa499c88b2741556ef9d0b