Zobrazeno 1 - 10
of 172
pro vyhledávání: '"Gábor, Bánhegyi"'
Autor:
Margita Márton, Gábor Bánhegyi, Norbert Gyöngyösi, Eszter Éva Kálmán, Aladár Pettkó‐Szandtner, Krisztina Káldi, Orsolya Kapuy
Publikováno v:
FEBS Open Bio, Vol 12, Iss 11, Pp 2065-2082 (2022)
Endoplasmic reticulum (ER) stress‐dependent accumulation of incorrectly folded proteins leads to activation of the unfolded protein response. The role of the unfolded protein response (UPR) is to avoid cell damage and restore the homeostatic state
Externí odkaz:
https://doaj.org/article/13614439e3c84ceba43168b1ac76dbb7
Autor:
Beáta Lizák, Julia Birk, Melinda Zana, Gergely Kosztyi, Denise V. Kratschmar, Alex Odermatt, Richard Zimmermann, Miklós Geiszt, Christian Appenzeller-Herzog, Gábor Bánhegyi
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-16 (2020)
Abstract Background The lumen of the endoplasmic reticulum (ER) acts as a cellular Ca2+ store and a site for oxidative protein folding, which is controlled by the reduced glutathione (GSH) and glutathione-disulfide (GSSG) redox pair. Although depleti
Externí odkaz:
https://doaj.org/article/6e96e7b7282a4f3fb5aef956daf86129
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207949 (2018)
Oxidative stress results in activation of several signal transduction pathways controlled by the PERK-substrate NRF2 (nuclear factor erythroid 2-related factor 2); meanwhile the ongoing cell division cycle has to be blocked. It has been recently show
Externí odkaz:
https://doaj.org/article/3787733e3968452d838a05d510cd7417
Autor:
Diána Brauswetter, Bianka Gurbi, Attila Varga, Edit Várkondi, Richárd Schwab, Gábor Bánhegyi, Orsolya Fábián, György Kéri, István Vályi-Nagy, István Peták
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185687 (2017)
Pancreatic cancer is an increasing cause of cancer related death worldwide. KRAS is the dominant oncogene in this cancer type and molecular rationale would indicate, that inhibitors of the downstream target MEK could be appropriate targeted agents, b
Externí odkaz:
https://doaj.org/article/a86dc0d78bea4e2a92e9c631ca56458e
Publikováno v:
FEBS Open Bio, Vol 4, Iss C, Pp 704-713 (2014)
Unfolded or misfolded proteins in the endoplasmic reticulum (ER) trigger an adaptive ER stress response known as unfolded protein response (UPR). Depending on the severity of ER stress, either autophagy-controlled survival or apoptotic cell death can
Externí odkaz:
https://doaj.org/article/5326ebe3d6134e5189434f8dd5fe74f9
Publikováno v:
Antioxidants & Redox Signaling. 34:831-844
Significance: Persistent oxidative stress is a common feature of cancer cells, giving a specific weapon to selectively eliminate them. Ascorbate in pharmacological concentration can contribute to the suspended formation of hydroxyl radical via the Fe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4b3f49fad26cf9ef2ddf8cfa33ae5b3
https://doi.org/10.1089/ars.2019.7897
https://doi.org/10.1089/ars.2019.7897
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168359 (2016)
The balance of protein synthesis and proteolysis (i.e. proteostasis) is maintained by a complex regulatory network in which mTOR (mechanistic target of rapamycin serine/threonine kinase) pathway and unfolded protein response are prominent positive an
Externí odkaz:
https://doaj.org/article/bf1ce07aa1654ed0be37e26f4a3bcf04
Publikováno v:
FEBS Letters. 594:1112-1123
Scientific results have revealed that autophagy is able to promote cell survival in response to endoplasmic reticulum (ER) stress, while drastic events result in apoptotic cell death. Here, we analyse the important crosstalk of life-and-death decisio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8702f9ca19e4c84cb917a1cac87b4c
https://doi.org/10.1002/1873-3468.13689
https://doi.org/10.1002/1873-3468.13689
Publikováno v:
Antioxidants, Vol 7, Iss 3, p 39 (2018)
Although the primary role of autophagy-dependent cellular self-eating is cytoprotective upon various stress events (such as starvation, oxidative stress, and high temperatures), sustained autophagy might lead to cell death. A transcription factor cal
Externí odkaz:
https://doaj.org/article/b78f3913bacd48e38b3032e3273b9dbd
Autor:
Éva Margittai, Andy Willaert, Bert Callewaert, Zsofia Nemoda, Annekatrien Boel, Pál Szabó, Paul Coucke, Csilla E. Németh, Gábor Bánhegyi, Péter Lőw, Erzsébet Horváth, Marina Colombi
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2019 (2019)
Oxidative Medicine and Cellular Longevity
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
Oxidative Medicine and Cellular Longevity
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
Ascorbate requiring Fe2+/2-oxoglutarate-dependent dioxygenases located in the nucleoplasm have been shown to participate in epigenetic regulation of gene expression via histone and DNA demethylation. Transport of dehydroascorbic acid is impaired in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01f16248c445f570d6c73b375276423
https://doi.org/10.1155/2019/8156592
https://doi.org/10.1155/2019/8156592