Zobrazeno 1 - 10
of 305
pro vyhledávání: '"G, Zografi"'
Publikováno v:
Pharmaceutical research. 17(8)
To prepare amorphous quinapril hydrochloride (QHCl) by lyophilization and to compare its physical characteristics and chemical stability as a function of the initial pH of the pre-lyophilized solution.Amorphous QHCl samples were prepared by lyophiliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3c827d49126eb7faef58e1517785a42
https://pubmed.ncbi.nlm.nih.gov/11028937
https://pubmed.ncbi.nlm.nih.gov/11028937
Publikováno v:
Pharmaceutical research. 17(3)
Factors affecting the solid-state acid-catalyzed inversion of amorphous sucrose to glucose and fructose in the presence of colyophilized citric acid, with less than 0.1% w/w residual water, have been studied.Samples of citric acid and sucrose were ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::83dcc07756f628bbb01c0374ece860ef
https://pubmed.ncbi.nlm.nih.gov/10801227
https://pubmed.ncbi.nlm.nih.gov/10801227
Autor:
P, Tong, G, Zografi
Publikováno v:
Pharmaceutical research. 16(8)
Having previously studied the amorphous properties of indomethacin (IN) as a model compound for drugs rendered amorphous during processing, we report on the formation and characterization of its sodium salt in the amorphous state and a comparison bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::02b0a8213f11802183e1824acd24575c
https://pubmed.ncbi.nlm.nih.gov/10468018
https://pubmed.ncbi.nlm.nih.gov/10468018
Autor:
S L, Shamblin, G, Zografi
Publikováno v:
Pharmaceutical research. 16(7)
To measure the water vapor absorption behavior of sucrose-poly(vinyl pyrrolidone) (PVP) and sucrose-poly(vinyl pyrrolidone co-vinyl acetate) (PVP/VA) mixtures, prepared as amorphous solid solutions and as physical mixtures, and the effect of absorbed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cdc7eb66a7acf0d345acdf3f2d933009
https://pubmed.ncbi.nlm.nih.gov/10450941
https://pubmed.ncbi.nlm.nih.gov/10450941
Autor:
S L, Shamblin, G, Zografi
Publikováno v:
Pharmaceutical research. 15(12)
To compare the enthalpy relaxation of amorphous sucrose and co-lyophilized sucrose-additive mixtures near the calorimetric glass transition temperature, so as to measure the effects of additives on the molecular mobility of sucrose.Amorphous sucrose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54a74edb60cfa4ca06369130ce08cec0
https://pubmed.ncbi.nlm.nih.gov/9892465
https://pubmed.ncbi.nlm.nih.gov/9892465
Autor:
Q, Lu, G, Zografi
Publikováno v:
Pharmaceutical research. 15(8)
To better understand the nature of drug-excipient interactions we have studied the phase behavior of amorphous binary and ternary mixtures of citric acid, indomethacin and PVP, as model systems.We have prepared amorphous mixtures by co-melting or cop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8ba646de6b7a68bae08edb668a7f7da4
https://pubmed.ncbi.nlm.nih.gov/9706050
https://pubmed.ncbi.nlm.nih.gov/9706050
Autor:
V, Andronis, G, Zografi
Publikováno v:
Pharmaceutical research. 15(6)
To determine the relaxation times of supercooled indomethacin as a function of temperature and relative humidity above Tg, and to analyze the results in the context of being able to predict such behavior at various storage conditions.Dielectric relax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5f75095dd48e2dc877401bfb7e0daaa2
https://pubmed.ncbi.nlm.nih.gov/9647347
https://pubmed.ncbi.nlm.nih.gov/9647347
Autor:
L S, Taylor, G, Zografi
Publikováno v:
Pharmaceutical research. 15(5)
To establish if FT-Raman spectroscopy can be used to quantitate the degree of crystallinity in a model compound.Mixtures containing different proportions of amorphous and crystalline indomethacin were prepared. Using the peak intensity ratio 1698 cm(
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::305a043b6faed7394aad28a5a0ab10dc
https://pubmed.ncbi.nlm.nih.gov/9619786
https://pubmed.ncbi.nlm.nih.gov/9619786
Autor:
L S, Taylor, G, Zografi
Publikováno v:
Pharmaceutical research. 14(12)
To study the molecular structure of indomethacin-PVP amorphous solid dispersions and identify any specific interactions between the components using vibrational spectroscopy.Solid dispersions of PVP and indomethacin were prepared using a solvent evap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::582b0481c4c718923ddcf0b43cda27e7
https://pubmed.ncbi.nlm.nih.gov/9453055
https://pubmed.ncbi.nlm.nih.gov/9453055
Autor:
V, Andronis, G, Zografi
Publikováno v:
Pharmaceutical research. 14(4)
To determine the viscosity and the frequency-dependent shear modulus of supercooled indomethacin as a function of temperature near and above its glass transition temperature and from these data to obtain a quantitative measure of its molecular mobili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::afc2354556c19df0f2bd51534843bc76
https://pubmed.ncbi.nlm.nih.gov/9144723
https://pubmed.ncbi.nlm.nih.gov/9144723