Zobrazeno 1 - 10
of 398
pro vyhledávání: '"G, Voelcker"'
Autor:
Hornemann, F.
Publikováno v:
Zeitschrift für neufranzösische Sprache und Literatur, 1888 Jan 01. 10, 209-230.
Externí odkaz:
https://www.jstor.org/stable/40609582
Autor:
G. Voelcker
Publikováno v:
Anti-cancer drugs. 32(1)
The pharmacologically active metabolite of cyclophosphamide is aldophosphamide. With cysteine, aldophosphamide forms stable aldophosphamide-thiazolidine which under physiological pH and temperature conditions hydrolyzes to aldophosphamide and cystein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37dd18f9613abe49a0a2811bfffbd273
https://pubmed.ncbi.nlm.nih.gov/32701559
https://pubmed.ncbi.nlm.nih.gov/32701559
Autor:
G. Voelcker
Publikováno v:
Anti-cancer drugs. 31(6)
Cyclophosphamide is an inert prodrug converted into 4-hydroxycyclophosphamide (OHCP) by hepatic hydroxylation. OHCP is in equilibrium with its tautomeric aldophosphamide (ALDO). From ALDO, the cytotoxic active metabolites are formed enzymatically by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7db39d11c99a2b72618c3ee7a1d395
https://pubmed.ncbi.nlm.nih.gov/32044797
https://pubmed.ncbi.nlm.nih.gov/32044797
Autor:
G. Voelcker
Publikováno v:
Anti-Cancer Drugs. 29:75-79
The present work investigates the influence of different DNA damages caused by different isophosphoramide mustards on the 3-hydroxypropanal-assisted apoptotic antitumor activity of oxazaphosphorine cytostatics using I-aldophosphamide-perhydrothiazine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e25a90439fe65ec57587c05aba342ca
https://doi.org/10.1097/cad.0000000000000569
https://doi.org/10.1097/cad.0000000000000569
Autor:
G. Voelcker
Publikováno v:
Anti-cancer drugs. 30(5)
On the basis of the discovery that the proapoptotic aldehyde 3-hydroxypropanal is a cyclophosphamide metabolite, a novel mechanism of action of oxazaphosphorine cytostatics is presented and confirmed by animal experiments. Furthermore, it is shown th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a432d0a1457d27b0e610700af31c4c10
https://pubmed.ncbi.nlm.nih.gov/30855309
https://pubmed.ncbi.nlm.nih.gov/30855309
Autor:
G. Voelcker
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 142:1183-1189
SUM-IAP has been developed with the aim to optimize therapeutic response and minimize toxic reactions of oxazaphosphorine cytostatics. In therapy tests in mice, the primary tumor was successfully eradicated, but animals died due to formation of letha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfd36c2b1626446ab281d6c98bce9200
https://doi.org/10.1007/s00432-016-2132-5
https://doi.org/10.1007/s00432-016-2132-5
Autor:
G. Voelcker
Publikováno v:
Anti-cancer drugs. 29(5)
SUM-IAP is an aldo-ifosfamide-perhydrothiazine derivative that, under physiological conditions, spontaneously hydrolyzes to SUM-aldo-ifosfamide. In SUM-IAP, one 2-chloroethyl group of the alkylating function of aldo-ifosfamide-perhydrothiazine is sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5aafd075e30240851f15fa6ff6dbbb5
https://pubmed.ncbi.nlm.nih.gov/29465464
https://pubmed.ncbi.nlm.nih.gov/29465464
Publikováno v:
Arzneimittelforschung. 50:843-847
Aldofosfamide-perhydrothiazine derivatives are a new class of prodrugs which spontaneously, with half-life times of 2 to > 12 h hydrolyse to the corresponding aldophosphamide in aquous solution. Synthesis of 1-aldofosfamide-perhydrothiazine (N,N'-(2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abb59c647df095ca8817cc3267e18030
https://doi.org/10.1055/s-0031-1300299
https://doi.org/10.1055/s-0031-1300299
Autor:
Rahman Khan, Mohammad Mizanur1 (AUTHOR) mmrkhan@gachon.ac.kr, Asrafali, Shakila Parveen2 (AUTHOR) shakilaparveen@yu.ac.kr, Periyasamy, Thirukumaran2 (AUTHOR) shakilaparveen@yu.ac.kr
Publikováno v:
Polymers (20734360). Oct2024, Vol. 16 Issue 19, p2701. 21p.
